4410 total record number 100 records this year

Diffusion MRI quantifies early axonal loss in the presence of nerve swelling

Lin, TH;Chiang, CW;Perez-Torres, CJ;Sun, P;Wallendorf, M;Schmidt, RE;Cross, AH;Song, SK;

Magnetic resonance imaging markers have been widely used to detect and quantify white matter pathologies in multiple sclerosis. We have recently developed a diffusion basis spectrum imaging (DBSI) to distinguish and quantify co-existing axonal injury, demyelination, and inflammation in multiple sclerosis patients and animal models. It could serve as a longitudinal marker for axonal loss, a primary cause of permanent neurological impairments and disease progression.