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Effect of endotoxin and alum adjuvant vaccine on peanut allergy

Johnson-Weaver, BT;McRitchie, S;Mercier, KA;Pathmasiri, W;Sumner, SJ;Chan, C;Germolec, D;Kulis, M;Burks, AW;Staats, HF;

Environmental endotoxin and alum-adjuvanted vaccines did not influence peanut-allergy development in mice. Exposure to alum and CpG-adjuvanted vaccines indirectly reduced allergic disease severity. Fecal metabolites differentiated mice based on disease severity.