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Effect of antihelminthic treatment on immunogenicity in a population very susceptible to geohelminths

Bruckner, SC;

Worm infections are particularly widespread in the sub-Saharan region and can lead to Impairments in cognitive and physical abilities contribute as well as that
Immune system affect what is especially in relation to vaccinations too is taken into account. Recently it was shown that after an oral
administered vaccination against cholera in individuals infected with A. lumbricoides a decreased immune response was elicited. A few others
Studies done in mice and humans have suggested that Helminth infections affect vaccine responses. For this reason, a randomized placebo-controlled study in Gabon,
Central Africa, with the aim of establishing a possible link between To study immunogenicity of vaccinations and worm infections. There were three
different vaccinations, each with a different application, chosen to get one possible difference between the different types of application of the
To be able to detect vaccinations. There were 98, 104 and 105 per vaccination group School children aged 6-10 years were included in the study, one of whom
Half an antihelminth treatment and the other half a placebo four Weeks before vaccination. Subsequently, the subjects were either with a seasonal influenza vaccination (intramuscular), one
Meningococcal vaccination (subcutaneous) or an oral cholera vaccination. There were both antibody titers and antibody-secreting cells that
Memory B-cells represent examined for the respective vaccine antigen. It could not find any statistically significant differences in the immune response to the
Vaccinations will be determined. Neither the antibody titers nor the antibody secreting cells provided a significant difference between the antihelminth treated group and the placebo group. Still it was a trend for higher immunogenicity in the anthelmintic treated group compared to the control group at the influenza vaccination. The immunoglobulin isotypes were also examined. There were significantly higher total IgA antibody titers in those treated with antihelminthic treatment Group versus control group for influenza vaccination found on day 28.
The basic titer (before vaccination) of the two groups was not different.  In general, it was found that regardless of the Group compared with significant immunogenicity three months after vaccination the baseline pointed to the vaccine antigens tested. The influence of one single deworming therapy four weeks before vaccination in our collective
but had no effect on immunogenicity.