Evidence for Endotoxin Contamination in Plastic Na+ - Heparin Blood Collection Tube Lots

Clinical Chemistry

Newhall KJ, Diemer GS, Leshinsky N, Kerkof K, Chute HT, Russell CB, Rees W, Welcher AA, Patterson SD, Means GD

Biomarker assays are often conducted on whole blood samples in the course of drug development studies. Because bacterial lipopolysaccharide (LPS) (endotoxin) contamination is known to cause spontaneous cytokine production by monocytes, contamination of blood collection tubes may interfere with biomarker assay results.

PubMed ID: 20663962

Citation

Evidence for Endotoxin Contamination in Plastic Na+ – Heparin Blood Collection Tube Lots