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Exploiting CD22 on Antigen-Specific B-Cells to Prevent Allergy to the Major Peanut Allergen Ara h 2

Orgel, KA;Duan, S;Wright, BL;Maleki, SJ;Wolf, JC;Vickery, BP;Burks, AW;Paulson, JC;Kulis, MD;Macauley, MS;

Methods for inducing antigen-specific immune tolerance are needed for the treatment and prevention of food allergies. We demonstrate that mice can be tolerized to the major peanut allergen through engaging CD22, an inhibitory B-cell co-receptor.