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Human adipose tissue-derived mesenchymal stromal cells promote B-cell motility and chemoattraction

Barrio, L;Cuevas, VD;Menta, R;Mancheo-Corvo, P;delaRosa, O;Dalemans, W;Lombardo, E;Carrasco, YR;

Mesenchymal stromal cells hold special interest for cell-based therapy because of their tissue-regenerative and immunosuppressive abilities. B-cell involvement in chronic inflammatory and autoimmune pathologies makes them a desirable target for cell-based therapy. Mesenchymal stromal cells are able to regulate B-cell function; although the mechanisms are little known, they imply cell-to-cell contact.,We studied the ability of human adipose tissue-derived mesenchymal stromal cells (ASCs) to attract B cells.,We show that ASCs promote B-cell migration through the secretion of chemotactic factors. Inflammatory/innate signals do not modify ASC capacity to mediate B-cell motility and chemotaxis. Analysis of a panel of B cell-related chemokines showed that none of them appeared to be responsible for B-cell motility. Other ASC-secreted factors able to promote cell motility and chemotaxis, such as the cytokine interleukin-8 and prostaglandin E2, did not appear to be implicated.,We propose that ASC promotion of B-cell migration by undefined secreted factors is crucial for ASC regulation of B-cell responses.