Citation

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Lymphotoxin targeted to salivary and lacrimal glands induces tertiary lymphoid organs and cervical lymphadenopathy and reduces tear production

Truman, LA;Bentley, KL;Ruddle, NH;

To investigate the role of lymphotoxin (LT) in Sjgren’s syndrome (SS) and in mucosal associated lymphoid tissue (MALT)-lymphoma, we made transgenic mice (Amy1-LT) that targeted LT and LT to the salivary and lacrimal glands. Amy1-LT mice developed atrophic salivary and lacrimal glands that contained tertiary lymphoid organs (TLOs) and had reduced tear production. Amy1-LT mice developed cervical lymphadenopathy but not MALT-lymphoma. TLO formation in the salivary and lacrimal glands of Amy1-LT was not sufficient to induce autoimmunity as measured by autoantibody titres. 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.