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MicroRNA-96-5p represses breast cancer proliferation and invasion through Wnt/-catenin signaling via targeting CTNND1

Gao, XH;Zhang, YL;Zhang, ZY;Guo, SS;Chen, XB;Guo, YZ;

Low miR-96-5p expression is characteristic of many cancers but its role in breast cancer (BCa) remains poorly defined. Here, the role of miR-96-5p in BC development was assessed. We demonstrate that exogenously expressing miR-96-5p inhibits the proliferative, migratory and invasive capacity of BCa cells. Mechanistically, miR-96-5p in BCa cells was found to target and downregulate catenin delta 1 (CTNND1) leading to decreased -catenin expression, a loss of WNT11 signaling, reduced cyclin D1 levels and lower MMP7 expression. Exogenously expressing CTNND1 alleviated these effects. In summary, we are the first to reveal that miR-96-5p inhibits the proliferative, invasive and migratory phenotypes of BCa cells the targeting of CTNND1 and subsequent Wnt/-catenin signaling. These data highlight miR-96-5p as a novel target for BC treatment.