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Modelling Mog Antibody-Associated Disorder and Neuromyelitis Optica Spectrum Disorder in Animal Models: Spinal Cord Manifestations

Remlinger, J;Bagnoud, M;Meli, I;Massy, M;Linington, C;Chan, A;Bennett, J;Hoepner, R;Enzmann, V;Salmen, A;

Antibodies to myelin oligodendrocyte glycoprotein (MOG-IgG) or aquaporin 4 (AQP4-IgG) are associated with CNS inflammatory disorders. We directly compared MOG35-55-induced experimental autoimmune encephalomyelitis exacerbated by MOG- and AQP4-IgG (versus isotype IgG, Iso-IgG). Disease severity was highest after MOG-IgG application. MOG- and AQP4-IgG administration increased disease incidence compared to Iso-IgG. Inflammatory lesions appeared earlier and with distinct localizations after AQP4-IgG administration. AQP4 intensity was more reduced after AQP4- than MOG-IgG administration at acute disease phase. The described models are suitable for comparative analyses of pathological features associated with MOG- and AQP4-IgG and the investigation of therapeutic interventions.