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Noninvasive Detection and Differentiation of Axonal Injury/Loss, Demyelination, and Inflammation

Song, SK;Spees, WM;Sun, P;Wang, Y;Cross, A;

Chronic progressive EAE was induced in 8  10 week old mice on day 0 by subcutaneous injection of a homogenized mixture of 200 g MOG 35  55 peptide (Genscript, Piscataway, NJ) in 50 L of PBS with 50 L of incomplete Freund's adjuvant (Sigma Aldrich, St. Louis, MO) containing 4 mg/mL Mycobacterium tuberculosis H37Ra (BD Diagnostic Systems, Sparks, MD). An intraperitoneal injection of 200 ng of pertussis toxin (List Biological Laboratories, Campbell CA) in 100 L of PBS was also delivered on days 0 and 2. CeNP and Fingolimod Administration. CeNPs were administere