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Selective sensitization of human neutrophils to LukGH mediated cytotoxicity by Staphylococcus aureus and IL-8

Janesch, P;Rouha, H;Weber, S;Malafa, S;Gross, K;Maierhofer, B;Badarau, A;Visram, ZC;Stulik, L;Nagy, E;

Staphylococcus aureus produces up to five bi-component leukocidins – LukSF-PV, gamma-hemolysins AB and CB, LukGH (LukAB) and LukED – to evade innate immunity by lysing phagocytic cells. Species specificity of these leukocidins limits the relevance of animal models, therefore we assessed their individual contribution using human neutrophils.