Citation

Genetic fate mapping confirmed the existence of the TIMD4hiMHCⅡhi macrophage subset and showed that they were resident macrophages with minimal input from peripheral monocytes. Further, single-cell RNA sequencing revealed that Retnla could serve as the signature gene for TIMD4hiMHCⅡhi macrophages. Administration of recombinant protein of the Retnla gene, RELMα, delayed the onset of heart failure, whereas either deletion of TIMD4hiMHCⅡhi macrophages or macrophage-specific loss of Retnla facilitated heart failure progression.