Diphtheria toxoid (DTd) is prepared by formaldehyde inactivation of purified diphtheria toxin. Inactivated bacterial toxins, including DTd, are widely used as protein carriers chemically conjugated to oligosaccarides in licensed vaccines, which induce a more robust immune response against the carbohydrate.
Product #151 Diphtheria toxoid is provided lyophilized in sodium phosphate buffer. Cytotoxicity testing results are described on a C of A that is included with every shipment.
By: Mary N. Wessling, Ph.D. ELS List Biological Laboratories’ (List Labs) catalog of products is related to furthering research in human health and preventing disease, most commonly as the starting materials for vaccine research & development or production around the world. Vaccines are mainly identified for their capacity to prevent diseases that the body’s innate defensive […]
By: Rachel Berlin, Marketing Manager The List Labs website hosts a library of scientific article abstracts related to the research performed using our products called the Citations Page. Visitors can search this library to learn how others have used List Labs’ reagents in their research. This valuable resource is updated monthly with new articles from a wide variety […]
By: Mary N. Wessling, Ph.D. ELS Cross-Reacting Materials: The Motor Behind Conjugate Vaccines Vaccines in history The history and practice of vaccination as protection against viral infection is often thought to begin with Edward Jenner’s discovery that cowpox, a viral infection of cows, prevented smallpox in humans. However, it had long been suspected that survivors […]
By: Suzanne Canada, Ph.D. Diphtheria toxin is an important tool used for selective killing (ablation) of cells for research purposes. Using this technique, dubbed “toxin receptor–mediated cell knockout” when it was first used , researchers can selectively remove a specific type of cell in a live mouse without having to generate transgenic “knockout” animals, which […]
By: Md. Elias, Ph.D, Senior Scientist List Labs is one of the leading manufacturers of high quality adjuvants from bacterial sources. Our highly purified adjuvants for research and development are Tetanus Toxoid (Product #191), Cholera Toxin B Subunit (Product #104), Diphtheria Toxin CRM197 Mutant (Product #149), Adenylate Cyclase Mutant, Cya-AC– (Product #198L), Pertusis Toxin Mutant (Product #184), […]
By: Karen Crawford, Ph.D., President In 1983, List Labs introduced Diphtheria Toxin to the research community. Researchers have purchased Diphtheria Toxin for various uses. One common use is cell ablation. The receptor for Diphtheria Toxin is also called heparin-binding EGF-like growth factor (HB-EGF). This receptor, located on several cell types, binds Diphtheria Toxin, allowing the toxin to enter […]
By: Suzanne Canada, Ph.D. Tanager Medical Writing Concerns over outbreaks of potentially serious childhood diseases are in the news again in California with an increase in whooping cough infections in 2014, caused by the pathogen Bordetella pertussis, and a measles outbreak in December 2014 to February 2015. Since outbreaks and epidemics may be infrequent, many […]
By: Suzanne Canada, Ph.D. Tanager Medical Writing An exciting report was released in October about a new class of targeted anti-tumor drugs, in which genetically engineered stem cells were used to deliver cytotoxins to brain tumors.1 Brain cancers known as glioblastomas (GBM) are notoriously difficult to treat because the tumors often re-grow after surgery and because […]
By: Suzanne Canada, Ph.D. Tanager Medical Writing Vaccines have been used to help control diseases for more than 200 years and are the common practice for children and adults. Childhood vaccination has substantially reduced the morbidity and mortality from infectious diseases in much of the developed world, and influenza vaccinations have reduced the impact […]