Protein Purification Services

List Labs offers comprehensive Protein Purification services backed by decades of expertise.

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Protein Purification

Protein Purification Solutions

Approachable Expertise: We take pride in offering the pinnacle of scientific know how, while remaining approachable, flexible, and collaborative– explaining our methods clearly and working closely with clients. Our experts guide you through the purification journey, ensuring you understand each step and expected outcome.

We specialize in purifying recombinant and native proteins to high levels of purity, ensuring that contaminants (like endotoxins) are minimized. Our services support projects from early R&D through Phase I/II clinical trials, reflecting List Labs’ long-standing experience in producing quality biological products.

Protein Purification Expertise

Trusted Experience: With over 45 years of experience in the development and manufacture of bacteria-based products, our team has developed robust purification processes for a variety of proteins. Whether you need milligram-scale research batches or GMP-grade material for clinical supply, List Labs has the capacity and know-how to deliver.

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Capabilities, Technologies & Expertise

Advanced Chromatography Techniques: We employ state-of-the-art chromatography systems (including multiple ÄKTA™ FPLC units) for high-resolution protein purification. Our expertise spans affinity chromatography (our method of choice for recombinant proteins), ion exchange, size-exclusion, and other techniques to isolate your target protein with exceptional purity.

Expert Team & Process Optimization: Our scientific team has deep expertise in protein chemistry and microbial expression systems (e.g., E. coli, B. subtilis, and others). We optimize each purification process – from cell lysis and initial capture to polishing steps – to maximize yield and purity. Each project benefits from an initial tech transfer and small-scale development phase to refine the process before larger-scale runs.

Specialized Equipment: In addition to chromatography, our facility is equipped with Tangential Flow Filtration units for concentration and buffer exchange, large-scale lyophilizers for gentle drying of purified proteins, and controlled environments (ISO7/ISO8 cleanrooms) for sensitive processing. This comprehensive toolset enables us to purify proteins while maintaining activity and stability.

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Cell Bank Preservation

Media Optimization

Fermentation

Protein Expression Optimization

Purification

Lyophilization

Analytical Method

Process Scale-Up

Applications and Industries Served

Biopharmaceuticals & Therapeutics: High-purity proteins are critical for therapeutic development. We purify vaccine antigens, enzymes, and therapeutic proteins, supporting pharmaceutical and biotech companies in developing vaccines and biologic drugs. Our purified proteins have been used globally in preclinical and clinical settings to treat a wide variety of conditions.

Research Reagents & Diagnostics: Academic institutions, research labs, and diagnostic developers rely on our protein purification services for research-grade reagents. Whether it's an antigen for an assay or a toxin for research use, we deliver consistent quality that scientists trust. (List Labs has produced over 100 reagent-grade bacterial products in its history, demonstrating our breadth of expertise)

Live Biotherapeutics & Microbiome Studies: For companies developing live biotherapeutic products (LBPs) or microbiome-based therapies, we purify associated proteins (such as bacterially expressed therapeutic proteins or biomarkers) with care to avoid disrupting live cultures. Our experience as a leading Microbial CDMO means we understand the unique needs of microbiome-related projects.

Government & Specialty Projects: We have supported government organizations and specialty biotech start-ups in purifying proteins for biodefense, vaccine R&D, and other niche applications. No matter the industry or application, if high-quality protein isolation is required, List Labs can tailor its services to meet those needs.

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cGMP Master and Working Cell Bank Production

cGMP Drug Substance Production

cGMP Drug Product Production

Research Cell Bank Production

Formulation and Lyophilization

Sieving and Dry Filling

Liquid Filling

Custom Packaging

Equipment

list labs equipment list

QC Analytic Testing

qC analytical testing

Questions?

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The highly skilled team at List Labs has extensive experience with cGMP manufacturing

Benefits of Choosing List Labs for Protein Purification

Proven Track Record: List Labs’ long history and focused expertise in bacterial protein production translate into purification success for our clients.

Scalability and Agility: From early development to clinical supply, we ensure your protein purification process is scalable, reproducible, and efficient.

Expert Guidance & Support: When you work with List Labs, you gain a collaborative partner. Our scientists and project managers provide personalized support, keeping you informed at every step.

Integrated Services Under One Roof: Uniquely, List Labs can handle entire workflows in-house – from fermentation and expression of your protein, through purification, to fill/finish and lyophilization.