List Labs currently has a GMP compliant version of HPT™ Lipopolysaccharide from Escherichia coli O113 in stock. What this means for you:

• You don’t need to buy an entire batch of lipopolysaccharide or wait months for production and release – Saves you valuable time
• Paying for as few as 50 vials of a proven product and purchasing as you need it, while supplies last, also saves you a tremendous amount of money
• Proven quality, product in use worldwide in clinical trials

Get to Phase one quickly with available GMP products

Time is money. The more time spent waiting for your materials to be manufactured is time that you are not conducting your clinical trials. Contracting a manufacturer to produce GMP products can take a year or more for manufacture and release, but with a GMP compliant product in stock, you can purchase what you need when you are ready.

Help your budget with available GMP products 

There are so many costs associated with research studies and clinical trials, who wouldn’t want to save a little money on their project? The expense of custom manufacturing can be steep – purchasing available GMP compliant products from List Labs can help alleviate some of those costs. Lipopolysaccharide is broadly used in many types of clinical trials such as in the study of tumor Ag-loaded IL-12 secreting semi-mature DC for the treatment of pediatric cancer.¹

Lipopolysaccharide currently in use in clinical trials worldwide

List Labs’ GMP compliant version of HPT™ Lipopolysaccharide from Escherichia coli O113 has already been used by organizations around the world in clinical trials. The quality of this product is proven by the successful use in Phases one through three in past or ongoing clinical trials. This unique difference sets our GMP product apart from the competition and saves you the risk of an unknown product.

Contact us today to get your GMP LPS while there’s still product in stock!

See how List Labs’ products have been used in research projects on our citations page.

Reference

1. Dohnal AM, Witt V, Hügel H, Holter W, Gadner H, Felzmann T. Phase I study of tumor Ag-loaded IL-12 secreting semi-mature DC for the treatment of pediatric cancer. Cytotherapy. 2007;9(8):755-70. Epub 2007 Oct 4. PMID: 17917887

By: Rachel Berlin, Marketing Manager

Microbiome research is uncovering the enormous potential for developing drugs, such a live biotherapeutic products, from the microbiome.  This burgeoning field is the future of medicine.

List Labs is excited and proud to support microbiome research by providing reagents to scientists studying the human microbiome. Below is a list of microbiome research studies that have used List Labs’ research reagents such as Athrax, Pertussis, Cholera and Difficile Toxins.

Pertussis Toxins Used in Microbiome Research:

• Products #180 – Pertussis Toxin from B. pertussis, Lyophilized in Buffer and #181 – Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free) have been used in the study of regulation of autoimmune myocarditis by host responses to the microbiome
• Product #179A – Pertussis Toxin from B. pertussis (in Glycerol) has been used in the study of bidirectional association between the gut micobiota and CNS disease in a biphasic murine model of multiple sclerosis
• Products #180 – Pertussis Toxin from B. pertussis, Lyophilized in Buffer and Product #181 – Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free) were used in the study of CD44 deletion leading to attenuation of experimental autoimmune encephalomyelitis results from alterations in gut microbiome in mice
• Products #180 – Pertussis Toxin from B. pertussis, Lyophilized in Buffer and #181 – Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free) have been used to study the effect of omeprazole on the development of experimental autoimmune encephalomyelitis in C57BL/6J and SJL/J mice
• Products #180 – Pertussis Toxin from B. pertussis, Lyophilized in Buffer and #181 – Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free) have been used to study an intestinal commensal symbiosis factor controls neuroinflammation via TLR2-medicated CD39 signalling
• Products #180 – Pertussis Toxin from B. pertussis, Lyophilized in Buffer and #181 – Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free) have been used to show a commensal bacterial product elicits an modulates migratory capacity of CD39(+) CD4 T regulatory subsets in the suppression of neuroinflammation
• Products #180 – Pertussis Toxin from B. pertussis, Lyophilized in Buffer and #181 – Pertussis Toxin from B. pertussis, Lyophilized (Salt-Free) have been used to show dominant effects on the diet on the microbiome and the local and systemic immune response in mice

Difficile Toxins Used in Microbiome Research: 

• Product #152C – Toxin A from Clostridium difficile and product #155 – Toxin B from Clostridium difficile were used in researching Immunogenicity and protective efficacy of recombinant Clostridium difficile flagellar protein FliC
• Product #152C – Toxin A from Clostridium difficile and product #155 – Toxin B from Clostridium difficile were used in researching an in vitro culture model to study the dynamics of colonic microbiota in Syrian golden hamsters and their susceptibility to infection with Clostridium difficile

Cholera Toxins Used in Microbiome Research: 

• Product #103B Cholera Toxin B Subunit (Choleragenoid) from Vibrio cholerae and product #104 – Cholera Toxin B Subunit (Choleragenoid) from Vibrio cholerae in Low Salt were used to study the immunogenicty and effects on fecal microbiome of an electron-beam inactivated rhodococcus equi vaccine in neonatal foals
• Product #103B Cholera Toxin B Subunit (Choleragenoid) from Vibrio cholerae and product #104 – Cholera Toxin B Subunit (Choleragenoid) from Vibrio cholerae in Low Salt were used to study the effects of administration of live or inactivated virulent Rhodococcus equi and age on the fecal microbiome of neonatal foals
• Product #101 – Cholera Toxin from Vibrio cholerae was used in research finding that parental dietary fat intake alters offspring microbiome and immunity

Anthrax Products

• Product #171 – Anthrax Protective Antigen (PA), Recombinant from B. anthracis was used in research finding that substrate cleavage profiling suggests a distinct function of bacteroides fragilis metalloproteinases (fragilysin and metalloproteinase II) at the microbiome-inflammation-cancer inferface

 

In addition to producing products for microbiome research, List Labs also provides contract GMP manufacturing of live biotherapeutic products for phases 1-3 of clinical trials. For more information on microbiome and live biotherapeutics- check out this blog post or watch our informative video. See how scientists have used our products in their research on our citations page.

Contact us to discuss your next project!

By: Rachel Berlin, Marketing Manager

The List Labs website hosts a library of scientific article abstracts related to the research performed using our products called the Citations Page. Visitors can search this library to learn how others have used List Labs’ reagents in their research. This valuable resource is updated monthly with new articles from a wide variety of publications. Check out a few recent articles below:

Botulinum Neurotoxin

• High Yield Preparation of Functionally Active Catalytic-Translocational Domain Module of Botulinum Neurotoxin Type A That Exhibits Uniquely Different Enzyme Kinetics 
• Augmentation of VAMP-catalytic activity of botulinum neurotoxin serotype B does not result in increased potency in physiological systems
• Detection and Quantification of Biologically Active Botulinum Neurotoxin Serotypes A and B using Förester Resonance Energy Transfer-based Quantum Dot Nanobiosensor 

Carrier Proteins

• Complexation hydrogels as potential carriers in oral vaccine delivery systems 
• Efficacy, but not antibody titer or affinity, of a heroin hapten conjugate vaccine correlates with increasing hapten densities on tetanus toxoid, but not on CRM197 carriers

Clostridium difficile toxin

• Catch-slip behavior observed upon rupturing membrane-cytoskeleton bonds
• Immunization with Recombinant TcdB-Encapsulated Nanocomplex Induces Protection against Clostridium difficile Challenge in a Mouse Model
• Clostridium difficile chimeric toxin receptor binding domain vaccine induced protection against different strains in active and passive challenge models 

Lipopolysaccharide (LPS)

• A quantitative method for microstructural analysis of myelinated axons in the injured rodent brain
• Innate immune responses of equine monocytes cultured in equine platelet lysate
• Cationic peptides from peptic hydrolysates of rice endosperm protein exhibit antimicrobial, LPS-neutralizing, and angiogenic activities

Diphtheria toxin

• Auditory Neuropathy after Damage to Cochlear Spiral Ganglion Neurons in Mice Resulting from Conditional Expression of Diphtheria Toxin Receptors
• Monocytes Promote Crescent Formation in Anti-Myeloperoxidase Antibody-Induced Glomerulonephritis
• Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis

Don’t see the reagent you’re interested in? You can search the citations by product, year, publication, or by the type of cell, animal, assay, protein or research. Check it out today!

By: Rachel Berlin, Marketing Manager

List Labs provides expert GMP contract manufacturing services to aid you in developing product for your clinical trial. The List Labs difference is that we manufacture reagent grade biological toxins regularly for resale, which means that not only do we have current, state-of-the art facilities and equipment, but we also have the experience and expertise to provide our customers with the highest quality products available. We even have a GMP LPS product currently in stock. Here are five reasons List Labs can make a critical difference in your success as a GMP manufacturing partner.

1. Product Manufacturing Experience

List Labs has nearly 40 years of experience cultivating anaerobic and aerobic organisms. Because we manufacture our own products, we are up to date with the most current regulations and best practices for the highest quality of product manufacturing. We are used to cultivating hard to grow organisms and thrive on the challenge.

2. Biological Toxins Expertise

Our team of scientists, many with PHDs, have the expertise for manufacturing obligate anaerobes, spore forming organisms as well as aerobes. The majority of List Labs’ scientific management team has been here for over 20 years and has vast experience manufacturing biological toxins for research. As experts in their field, our scientists utilize their expertise to produce the highest quality research reagents on the market.

3. Quality Research Reagents

List Labs produces only the highest quality products for our customers to conduct their research. We are known for our quality products and attention to detail throughout the industry. Over the past 40 years in business, List Labs has honed our processes and facilities to produce only the highest quality research reagents and GMP compliant products.

4. Facilities Designed for GMP

Our state-of-the-art facility was designed with GMP work in mind and is constantly enhanced with new equipment and more efficient processes. Our lab provides containment for BL2 and BL3 organisms and spores, as well as segregation of projects. Contact us to come visit us and tour our facility.

5. GMP Capabilities

List Labs’ contract research & manufacturing capabilities include analytics, process development, media optimization, downstream and upstream processing and bulk and final product lyophilization. Most of our cultivation and harvesting operations are in full closed systems. We are also capable of working with spore formers, which many organizations are unable to work with due to the difficult nature of these strains and regulatory compliance. List Labs is one of only about 16 private companies in the US registered with the Federal Select Agent Program.

When choosing your GMP partner – make sure it’s someone you can trust. Consider List Labs for your next GMP project.

Contact us today! 

By: Allisa Clemens, Production Biochemist

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My name is Allisa Clemens, and I started working at List Labs about 2 years ago as a Production Biochemist within the Purification team. Prior to working at List Labs I was a full time graduate student and Teaching Associate in the Chemistry department at San Jose State University. While working on my research for my Master’s thesis, I quickly learned how scarce funding for equipment, reagents, and supplies can slow down progress.

In 2016, I began the Marguerite E. Bourez Donations for Academic Research program here at List Labs, to celebrate and pass on the generous spirit of my Aunt Marguerite, who, when I had nothing, gave me a home and enabled me to go to college, and eventually complete my Master of Science in Chemistry. Without her generous support, my own contribution to the scientific community might not have been possible. And I am not alone; over the years she has helped many people just like me.  Being a rocket scientist herself, she knows how education can not only present more career opportunities, but also enrich your life. My hope that this program will reflect her commitment to giving and advancing education.

Donations Program Gives to Deserving Academic Research Labs

The Rascón Research Group is one of such research groups. I first met Dr. Rascón when I took his graduate enzymology course at San Jose State University. No single academic course has made more of an impact in changing the way I think as a student and as a researcher. Dr. Rascón has been very generous with me over the years in offering me his time and expertise. So naturally, when I had the opportunity to give back, he was the first person I thought of. According to Dr. Rascón, “We at SJSU strive to provide research opportunities to our undergraduate and graduate students, but sometimes reagents and columns are hard to come by. With these columns we have been able to purify a couple of our proteolytic enzymes and have been able to show students the purification process.” The Rascón Research group is working to investigate and develop serine protease inhibitors for the Aedes aegypti mosquito. This invasive species is a vector for dengue fever, chikungunya virus, zika virus, and yellow fever read. The work his research group does provides invaluable information for vector control of these potentially deadly viruses.

Another research group we are proud to support is the Miller Conrad lab, which uses organic chemistry and molecular biology techniques to understand and combat virulence in the pathogen Pseudomonas aeruginosa. This opportunistic pathogen is responsible for an estimated 51,000 hospital acquired infections a year, with roughly 13% being multidrug resistant. As antibiotic resistance continues to be a global threat to health, we are eager to support this much needed humanitarian work.

Recent donations

Mills College – has a strong commitment for the advancement of women. Mills works hard to offer an affordable education to those and prides themselves on accepting those who have a desire and the qualification to attend, so over 98% of their undergraduate students received financial aid. Caroline Harmon, a Production Biochemist with List Labs, was one of these proud Alumnae. After being involved in a research project her first year, she was inspired to pursue biochemical research. The donations given to Mills College will aid the new biochemistry professor, Ana Mostafavi, to set up her lab. Professor Mostafavi is currently at the Muir Lab at Princeton and will be joining Mills in the Fall of 2019. Giving Mills equipment that they may not have been able to attain themselves, as Women’s colleges have seen a loss in financial donations. We hope that this donation will aid in training future researchers and promoting women in science, and will greatly improve these undergraduate students’ education.

To date, the Marguerite E. Bourez Donations for Academic Research program at List Labs has given over $100,000 worth of supplies, reagents, and equipment to a number of well deserving academic research labs. Included in the donations were a variety of AKTA columns and chromatography resins, various types of bacteria culture media, pipette tips, vials with stoppers, filters and gloves. If you would your academic research lab like to be considered to receive donations please contact Shawn Lyles.

List Labs Dedicated to Providing Reagents to Advance Research

List Labs’ heart is in the science and discovery of innovative research reagents, and we function to serve the global research community. List Biological Laboratories, Inc. is dedicated to providing research reagents to advance the understanding of disease and to further the development of vaccines, therapeutics and diagnostics. I am happy to have been able to make a small contribution on behalf of List Labs to the student and faculty research being performed by these outstanding research groups.

If you know of an academic research group that you would like to be considered for our donation program, please contact List Labs by emailing me with an explanation for the types of supplies, equipment, or reagents needed and a brief description of the research being performed. Donation of all equipment, supplies and reagents is contingent on availability.