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A Preclinical Study Comparing the Activity and Potency of OnabotulinumtoxinA and PrabotulinumtoxinA
Clinical, Cosmetic And Investigational Dermatology
Rupp, DC;Canty, D;Rhéaume, C;Sondergaard, B;Niño, C;Broide, RS;Brideau-Andersen, AD;
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
The goal of this study was to compare the unit-to-unit biological activity of the vacuum-dried formu....
Transformation of a Metal Chelate into a Catch and Anchor Inhibitor of Botulinum A Protease
International Journal Of Molecular Sciences
Lin, L;Patel, E;Nielsen, A;Turner, L;Tepp, W;Nguyen, K;Pellett, S;Janda, K;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
Targeting the botulinum neurotoxin light chain (LC) metalloprotease using small-molecule metal chela....
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
Botulinum neurotoxin A (BoNT/A), which causes botulism, is the most potent toxin known. Intoxication....
Botulinum Toxin as an Ultrasensitive Reporter for Bacterial and SARS-CoV-2 Nucleic Acid Diagnostics
Biosensors And Bioelectronics
Song, F;Shen, Y;Wei, Y;Yang, C;Ge, X;Wang, A;Li, C;Wan, Y;Li, J;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
The rapid identification of pathogenic microorganisms plays a crucial role in the timely diagnosis a....
Wrinkle in Time: Development of Botulinum Neurotoxin Light Chain a Inhibitors through Structure Activity Relationship Studies
Thesis
Ku, A;
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
The botulinum neurotoxin serotype A (BoNT/A) is the deadliest toxin known to man with a lethal dose ....
OnabotulinumtoxinA Displays Greater Biological Activity Compared to IncobotulinumtoxinA, Demonstrating Non-Interchangeability in Both In Vitro and In Vivo Assays
Toxins
Rupp, D;Nicholson, G;Canty, D;Wang, J;Rhaume, C;Le, L;Steward, LE;Washburn, M;Jacky, BP;Broide, RS;Philipp-Dormston, WG;Brin, MF;Brideau-Andersen, A;
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
Differences in botulinum neurotoxin manufacturing, formulation, and potency evaluation can impact do....
Differential endopeptidase activity of different forms of type A botulinum neurotoxin: A unique relationship between the size of the substrate and activity of the enzyme
Toxicon : Official Journal Of The International Society On Toxinology
Ambrin, G;Kumar, R;Singh, BR;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
Botulinum neurotoxins (BoNTs; serotypes A-G) are metalloproteases, which cleave and inactivate cellu....
High Yield Preparation of Functionally Active Catalytic-Translocation Domain Module of Botulinum Neurotoxin Type A That Exhibits Uniquely Different Enzyme Kinetics
The Protein Journal
Dhaliwal, HK;Thiruvanakarasu, N;Kumar, R;Patel, K;Ambrin, G;Cai, S;Singh, BR;
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
Botulinum neurotoxins (BoNTs) are the most toxic proteins known to cause flaccid muscle paralysis as....
Newly Designed Quinolinol Inhibitors Mitigate the Effects of Botulinum Neurotoxin A in Enzymatic, Cell-Based, and ex Vivo Assays
Journal of Medicinal Chemistry
Bremer, PT;Adler, M;Phung, CH;Singh, AK;Janda, KD;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
Botulinum neurotoxin A (BoNT/A) is one of the most deadly toxins and is the etiological agent of the....
Bithionol blocks pathogenicity of bacterial toxins, ricin, and Zika virus
Scientific Reports
Leonardi, W;Zilbermintz, L;Cheng, LW;Zozaya, J;Tran, SH;Elliott, JH;Polukhina, K;Manasherob, R;Li, A;Chi, X;Gharaibeh, D;Kenny, T;Zamani, R;Soloveva, V;Haddow, AD;Nasar, F;Bavari, S;Bassik, MC;Cohen, SN;Levitin, A;Martchenko, M;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
Diverse pathogenic agents often utilize overlapping host networks, and hub proteins within these net....
High-Throughput Screening Uncovers Novel Botulinum Neurotoxin Inhibitor Chemotypes
ACS Combinatorial Science
Bompiani, KM;Cagli, D;Krutein, MC;Benoni, G;Hrones, M;Lairson, LL;Bian, H;Smith, GR;Dickerson, TJ;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
Botulism is caused by potent and specific bacterial neurotoxins that infect host neurons and block n....
Identification of small molecule inhibitors of botulinum neurotoxin serotype E via footprint similarity.
Bioorganic & Medicinal Chemistry
Zhou, Y;McGillick, BE;Teng, YG;Haranahalli, K;Ojima, I;Swaminathan, S;Rizzo, RC;
Product: SNAP Etide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type E Neurotoxin
Botulinum neurotoxins (BoNT) are among the most poisonous substances known, and of the 7 serotypes (....
Investigation of the substrate recognition mechanisms of botulinum neurotoxin and its application in detection and therapy development
Thesis
Guo, J;
Product: VAMPtide® Peptide Substrate (o-Abz/Dnp) Substrate for C. botulinum Type B Neurotoxin
Removal of Botulinum Neurotoxin a Surrogate from Reusable Medical Device Surfaces
Applied Biosafety
Lucas, AD;Di Prima, MA;Hitchins, VM;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
Botulinum neurotoxin A (BoNT/A) is on the national select agent registry and can be an extremely pot....
A simple, rapid and sensitive FRET assay for botulinum neurotoxin serotype B detection
PLoS ONE
Guo, J;Xu, C;Li, X;Chen, S;
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
Botulinum neurotoxins (BoNTs), the most potent naturally-occurring neurotoxins known to humans, comp....
High-throughput screening technologies for botulinum neurotoxins
Current Topics In Medicinal Chemistry
Bompiani, KM;Dickerson, TJ;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
Botulinum neurotoxins (BoNTs) are a class of bacterial neurotoxins that are the most potent toxic co....
Benzoquinones as inhibitors of botulinum neurotoxin serotype A
Bioorganic & Medicinal Chemistry
Bremer, PT;Hixon, MS;Janda, KD;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
Although botulinum neurotoxin serotype A (BoNT/A) is known for its use in cosmetics, it causes a pot....
Differential role of molten globule and protein folding in distinguishing unique features of botulinum neurotoxin
Biochimica et Biophysica Acta (BBA) - Proteins And Proteomics
Kumar, R;Kukreja, RV;Cai, S;Singh, BR;
Product: VAMPtide® Peptide Substrate (o-Abz/Dnp) Substrate for C. botulinum Type B Neurotoxin
Botulinum neurotoxins (BoNTs) are proteins of great interest not only because of their extreme toxic....
Botulinum neurotoxin: unique folding of enzyme domain of the most-poisonous poison
Journal Of Biomolecular Structure And Dynamics
Kumar, R;Kukreja, RV;Li, L;Zhmurov, A;Kononova, O;Cai, S;Ahmed, SA;Barsegov, V;Singh, BR;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
Botulinum neurotoxin (BoNT), the most toxic substance known to mankind, is the first example of the ....
Identification of clinically viable quinolinol inhibitors of botulinum neurotoxin A light chain
Journal of Medicinal Chemistry
Cagli, D;Krutein, MC;Bompiani, KM;Barlow, DJ;Benoni, G;Pelletier, JC;Reitz, AB;Lairson, LL;Houseknecht, KL;Smith, GR;Dickerson, TJ;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
Botulinum neurotoxins (BoNT) are the most potent toxins known and a significant bioterrorist threat.....
A high-throughput-compatible FRET-based platform for identification and characterization of botulinum neurotoxin light chain modulators
Journal Of Visualized Experiments : JoVE
Cagli, D;Bompiani, KM;Krutein, MC;apek, P;Dickerson, TJ;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
Botulinum neurotoxin (BoNT) is a potent and potentially lethal bacterial toxin that binds to host mo....
Bioluminescence assay for the highly sensitive detection of botulinum neurotoxin A activity
Analyst
Stevens, GB;Silver, DA;Zgaga-Griesz, A;Bessler, WG;Vashist, SK;Patel, P;Achazi, K;Strotmeier, J;Worbs, S;Dorner, MB;Dorner, BG;Pauly, D;Rummel, A;Urban, GA;Krueger, M;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
This article describes a novel bioluminescence assay for detecting the proteolytic activity of Botul....
Substrates and controls for the quantitative detection of active botulinum neurotoxin in protease-containing samples
Analytical Chemistry
Bagramyan, K;Kaplan, BE;Cheng, LW;Strotmeier, J;Rummel, A;Kalkum, M;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
Botulinum neurotoxins (BoNTs) are used in a wide variety of medical applications, but there is limit....
Comparison of fluorigenic peptide substrates PL50, SNAPTide, and BoTest A/E for BoNT/A detection and quantification: exosite binding confers high-assay sensitivity.
Journal Of Biomolecular Screening
Ouimet, T;Duquesnoy, S;Poras, H;Fourni-Zaluski, MC;Roques, BP;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
Detection and quantification of low doses of botulinum toxin serotype A (BoNT/A) in medicinal prepar....
Development of a fluorescence internal quenching correction factor to correct botulinum neurotoxin type A endopeptidase kinetics using SNAPtide
Analytical Chemistry
Feltrup, TM;Singh, BR;
Product: Unquenched Calibration Peptide for SNAPtide® 521 Substrate for C. botulinum Type A Neurotoxin
Botulinum neurotoxins (BoNTs), which are highly toxic proteins responsible for botulism, are produce....
Metal ion-mediated inactivation and small molecule inhibition of the metalloprotease in botulinum neurotoxin A
Thesis
Feng, M;
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
Evaluation of Three VAMPtide Substrates for Botulinum Neurotoxin Type B
List Labs POSTER - Presented at the 49th Annual Interagency Botulinum Research Coordinating Committee Meeting, September 2012 in Baltimore Maryland
Shine, N.; Ouimet, T.
Product: VAMPtide® Peptide Substrate (o-Abz/Dnp) Substrate for C. botulinum Type B Neurotoxin
Background: Peptide substrates which are specific for Botulinum neurotoxin type B (BoNT/B) have been....
Mechanisms of SNAP-25 Association with Botulinum Neurotoxin Light Chain A and SNARE Proteins
Thesis
Sultani, M;
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
Development of highly sensitive chemiluminescence enzyme immunoassay based on the anti-recombinant HC subunit of botulinum neurotoxin type A monoclonal antibodies
Analytica Chimica Acta
Liu, Z;Song, C;Li, Y;Liu, F;Zhang, K;Sun, Y;Li, H;Wei, Y;Xu, Z;Zhang, C;Yang, A;Xu, Z;Yang, K;Jin, B;
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
Botulinum neurotoxins (BoNTs) are the most poisonous substances ever known. The early detection of t....
New FRET Substrate For Botulinum Neurotoxin Type A
List Labs POSTER - Presented at the 7th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins, October 2011 Santa
Shine, N.; Suryadi, K.
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
Purpose of Study: A new FRET peptide substrate for botulinum toxin type A (BoNT/A), marketed as SNAP....
New SV2c Construct for Use in Binding and Detecting Botulinum Neurotoxin Type A
List Labs POSTER - Presented at the 7th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins, October 2011
Christian, T.; Suryadi, K.; Shine, N.
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
Purpose of Study:The purpose of this study was to express and purify the luminal domain loop of huma....
Sensitive Detection of Botulinum Neurotoxin Type A Using High Affinity Polyclonal Antibodies
List Labs POSTER - Presented at the 7th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins, Santa Fe, NM.
Suryadi, K.; Christian, T.; Shine, N.
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
Purpose of Study: The purpose of this study was to determine if a polyclonal antibody directed towar....
Evaluation of a Small Peptide Inhibitor and A Control Peptide for Botulinum Neurotoxin, Type A
List Labs POSTER - Presented at the 47th Annual Interagency Botulinum Research Coordinating Committee Meeting, November 2010 in Atlanta, GA
Shine, N.; Suryadi, K.; Christian, T.
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
Botulinum neurotoxins are among the most toxic substances known to man. Four of the seven immunologi....
Ultra Sensitive HPLC Detection Assay for Botulinum Neurotoxin Type A
List Labs POSTER - Presented at the 47th Annual Interagency Botulinum Research Coordinating Committee Meeting, November 2010, Atlanta, GA
Christian, T.; Suryadi, K.; Shine, N.
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
The botulinumneurotoxins are among the most potent toxins in nature. They are synthesized as single ....
Characterization of SNARE Cleavage Products Generated by Formulated Botulinum Neurotoxin Type-A Drug Products
Toxins
Hunt T, Rupp D, Shimizu G, Tam K, Weidler J, Xie J.
Product: SYNTAXtide® (o-Abz/Dnp) Peptide Substrate for C. botulinum Type C Neurotoxin
The study evaluated substrate cleavage product(s) generated by three botulinum neurotoxin serotype A....
FRET Peptide Substrates for BotulinumNeurotoxins Types A, B, C, and E
List Labs POSTER - Presented at the 46th Annual Interagency Botulinum Research Coordinating Committee Meeting, October 2009 in Alexandria, VA
Shine, N.; Endrukaite,E.; Christian, T.
Product: VAMPtide® Peptide Substrate (o-Abz/Dnp) Substrate for C. botulinum Type B Neurotoxin
Thebotulinumneurotoxinsareamongthemosttoxicsubstancesknowntoman.Fouroftheseven immunologicallydistin....
Sensitive, In Vitro, Bifunctional, Potency Assay For Botulinum Neurotoxin Type A
List Labs POSTER - Presented at the 46th Annual Interagency Botulinum Research Coordinating Committee Meeting, October 2009 in Alexandria, VA.
Christian, T.; Shine, N.
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
Botulinum toxin progresses through a three step process leading to the interruption of synaptic tran....
Functional Assay for Botulinum Neurotoxin Type A Utilizing the Neuronal Receptor Protein SV2c.
List Labs POSTER - Presented at the 45th Annual Interagency Botulinum Research Coordinating Committee Meeting, September 2008 in Philadelphia, PA.
Christian, T.; Rummel, A.; Shine, N.
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
Botulinum toxin progresses through a three step process leading to the interruption of synaptic tran....
Capture Assay for Botulinum Neurotoxin Type A Utilizing the Neuronal Receptor Protein SV2c.
List Labs POSTER - Presented at the 6th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins, June 2008 in Baveno
Christian, T.; Shine, N.
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
Recent biochemical and molecular genetic studies have established synaptic vesicle glycoprotein 2c (....
New High Affinity Antibodies Against Botulinum Neurotoxin Type A
List Labs POSTER - Presented at the 6th Annual ASM Biodefense and Emerging Diseases Research Meeting, Baltimore, MD
Christian, T.; Shine, N.; Crawford, K.
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
New high affinity antibodies against Botulinum Neurotoxin Type A have been developed in chickens. Pr....
FRET Peptide Substrates for the Botulinum Toxins Type A, B, and E and for Anthrax Lethal Factor.
List Labs POSTER - Presented at the 5th Annual ASM Biodefense and Emerging Diseases Research Meeting, February 2007 in Washington, D.C.
Shine, N., Crawford, K.
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
SNAP-Etide, a FRET Substrate for Botulinum Toxin Type E
List Labs POSTER - Presented at the 43nd Annual IBRCC, November 2006 in Silver Springs, Maryland
Shine, N.; Christian, T.; Primak, Y.
Product: SNAP Etide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type E Neurotoxin
Botulinum neurotoxins have seven distinct serotypes, four of which (types A, B, E and F) cause botul....
Comparison of Activity of Botulinum Neurotoxin Type A Holotoxin and Light Chain Using SNAPtide FRET Substrates.
List Labs POSTER - Presented at the 5th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins, June 2005 in Denver
Christian, T.; Shine, N.; Eaton, L.; Crawford, K.
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
The botulinum neurotoxins are composed of two subunits, a 100 kD heavy chain and a 50 kD light chain....
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