List Labs sells a genetically inactivated form of pertussis toxin, Pertussis Toxin Mutant (PTMUT). This protein may be used as an antigen and as a carrier protein for other antigens.
Pertussis mutant protein is isolated from the TY-178 strain of Bordetella bronchiseptica. Site-directed mutagenesis was used to replace amino acid residues in the enzyme active site. Although diminished, this mutant retains some of the activity of the native toxin.
Product #184 Pertussis toxin mutant (R9K, E129A) is provided lyophilized in phosphate buffer and an accompanying C of A describes the CHO cell toxicity.
List Labs offers citations on our website for easy use by researchers. At present we have over 3,000 citations from publications around the world, with emphasis on the last 5 years. We provide information on how to purchase the referenced products and the ability to sort from among the over 100 catalog items we offer […]
By: Rachel Berlin, Marketing Manager Microbiome research is uncovering the enormous potential for developing drugs, such a live biotherapeutic products, from the microbiome. This burgeoning field is the future of medicine. List Labs is excited and proud to support microbiome research by providing reagents to scientists studying the human microbiome. Below is a list of microbiome […]
The origin of businesses is often an interesting story. List Biological Laboratories is no exception. The company was founded in 1978 by Linda Shoer. Linda was an entrepreneurial scientist in Silicon Valley, who’d been relocated with her husband from Boston. She had an idea for a company and leveraged an initial order into a loan […]
By: M. Wessling A recently published study by Wen et al  provides an encouraging look at a possible therapy for the chronic neuro-inflammatory disease multiple sclerosis (MS). What is even more interesting is that this experimental autoimmune encephalitis myelitis (EAE) study, which used the List Labs Product #180 Pertussis Toxin in mice to induce autoimmune […]
By: Md. Elias, Ph.D, Senior Scientist List Labs is one of the leading manufacturers of high quality adjuvants from bacterial sources. Our highly purified adjuvants for research and development are Tetanus Toxoid (Product #191), Cholera Toxin B Subunit (Product #104), Diphtheria Toxin CRM197 Mutant (Product #149), Adenylate Cyclase Mutant, Cya-AC– (Product #198L), Pertusis Toxin Mutant (Product #184), […]
By: Suzanne Canada, Ph.D. Tanager Medical Writing Concerns over outbreaks of potentially serious childhood diseases are in the news again in California with an increase in whooping cough infections in 2014, caused by the pathogen Bordetella pertussis, and a measles outbreak in December 2014 to February 2015. Since outbreaks and epidemics may be infrequent, many […]
By: Suzanne Canada, Ph.D. Tanager Medical Writing Vaccines have been used to help control diseases for more than 200 years and are the common practice for children and adults. Childhood vaccination has substantially reduced the morbidity and mortality from infectious diseases in much of the developed world, and influenza vaccinations have reduced the impact […]
By: Suzanne Canada, Ph.D. Tanager Medical Writing Pertussis Infections (aka Whooping Cough) Increasing Rates of pertussis infection, commonly referred to as whooping cough, are on the upswing. Whooping cough is a highly contagious respiratory infection with flu-like symptoms including a blocked or runny nose, sneezing, mild fever and the distinctive, hack-like cough. Prior to the […]