List Labs Bacterial Toxin & Vaccine Research Blog

Tetanus Toxin – Model Antigen and Protein Carrier

July 17, 2017

By: douano@listlabs.com

By: Mary N. Wessling, Ph.D. ELS Tetanus Toxin’s Use as a Protein Carrier and Antigen Tetanus toxin (TT) is the major virulence factor of the Gram-positive bacterium Clostridium tetani. Infection with this bacterium in unvaccinated persons produces muscle spasms by binding to nerve endings and moving throughout the nervous system in a specific way. Eventually, […]

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How is Cholera Toxin Used in Scientific Research?

June 5, 2017

By: douano@listlabs.com

By: Mary N. Wessling, Ph.D. ELS Cholera Toxin: Dual Roles in Disease and Scientific Advancement In 2010, Sanchez et al published an article with the puzzling title “Cholera toxin—A foe & a friend. ” The cholera toxin, a complex of two units produced by the pathogen Vibrio cholerae clearly plays the “foe” role [1]. […]

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Microbiome Research Requires GMP Facilities

May 15, 2017

By: douano@listlabs.com

By: Stacy Burns-Guydish, Ph.D., Senior Director, Microbiology The human body is home to a vast ecosystem of microbes, called the microbiome. Research is shedding light on the importance of the microbiome as a benefactor to our health and development. Perturbation of the microbiome has been associated with a growing number of diseases including inflammatory bowel [...]

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Carrier Protein Used in Life-Changing Research

March 27, 2017

By: douano@listlabs.com

By: Mary N. Wessling, Ph.D. ELS Cross-Reacting Materials: The Motor Behind Conjugate Vaccines Vaccines in history The history and practice of vaccination as protection against viral infection is often thought to begin with Edward Jenner’s discovery that cowpox, a viral infection of cows, prevented smallpox in humans. However, it had long been suspected that survivors […]

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List Labs Citation Library – A New Tool Available To Aid In Your Research Needs

March 13, 2017

By: douano@listlabs.com

List Labs offers a citation library to provide you with research papers that utilize List Labs products; these papers can provide supplemental information for your research. The number of available citations will continue to increase, as we will be adding new citations on a regular basis. Our citation library can be found here. The main [...]

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Endotoxins: Potency Testing and Low Endotoxin Recovery (LER/LLR) in Pharmaceutical Applications

March 6, 2017

By: douano@listlabs.com

By: Md. Elias, Ph.D, Senior Scientist What are Endotoxins? Endotoxins (aka lipopolysaccharide, LPS or lipoglycan) are part of the outer membrane of Gram-negative bacteria consisting of a lipid moiety and a polysaccharide moiety, the latter is composed of an inner core, outer core and O-antigen joined by covalent bonds1. In animals the lipid part of […]

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