Diphtheria Toxin for Cell Ablation
April 25, 2016
By: Karen Crawford, Ph.D., President
In 1983, List Labs introduced Diphtheria Toxin to the research community. Researchers have purchased Diphtheria Toxin for various uses. One common use is cell ablation. The receptor for Diphtheria Toxin is also called heparin-binding EGF-like growth factor (HB-EGF). This receptor, located on several cell types, binds Diphtheria Toxin, allowing the toxin to enter and kill these cells. Transgenic mice have been developed to express the diphtheria toxin receptor on dendritic cells allowing their depletion. Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae (Product #150) is an active native enzyme, a useful tool for your research.
Information on our entire family of Diphtheria products, including Diphtheria Toxoid (Product #151) and the mutant CRM197 (Product #149) can be found on our website. Other uses of Diphtheria Toxin and technical information can be found on our Knowledge Base & Support Portal.