Blog

August 30, 2021

By: douano@listlabs.com

By: Rachel Berlin, Marketing Manager List Labs currently has a GMP compliant version of HPT™ Lipopolysaccharide from Escherichia coli O113 in stock. What this means for you: You don’t need to buy an entire batch of lipopolysaccharide or wait months for production and release – Saves you valuable time Paying for as few as 50 vials of […]

March 19, 2021

By: List Labs

Botulinum Toxin Infographic  Diphtheria Toxin Infographic  Pertussis Toxin Infographic

October 21, 2020

By: List Labs

The purity of your recombinant proteins is critical to the success of your research. A number of contaminants can affect both in vitro and in vivo systems. Some of the results are predictable, but others are not. All can affect your experimental data. This article will focus on one of the most common contaminants: endotoxins […]

September 15, 2020

By: List Labs

The List Labs Citation Database is a robust tool for researchers. It offers thousands of papers showing how List Labs products are used experimentally. Researchers can search keywords specific to their fields of study and learn how others in that field have used our toxins and antigens. In this article, we will explore experimental applications […]

August 7, 2020

By: List Labs

Recent Research: Experimental Applications of Pertussis Toxin and Cholera Toxin The List Labs Citation Database is a robust tool for researchers. It offers thousands of papers showing how List Labs products are used experimentally. Researchers can search for keywords specific to their fields of study and learn how others in that field have used our […]

August 7, 2020

By: List Labs

List Labs has been making botulinum toxins for research for 30 years.  In that time, we’ve made reagent and GMP products for researchers and pharma companies.  Our products are of the highest quality and purity; they are produced in consistent processes, tested and stabilized by freeze-drying.  Proteins that need to be activated by proteolytic cleavage […]

October 17, 2019

By: List Labs

List Labs currently has over 3300 citations with more being added every month! Within our citations page, we provide the ability to search and sort from over 100 cataloged items that are offered here. We are honored to supply researchers worldwide with highly purified bacterial toxins that can potentially be instrumental in helping to change […]

April 24, 2019

By: List Labs

By: Hans Bigalke Tetanus toxin (TeNT) and botulinum toxin (BoNT) appear quite different at first glance, however, when we take a closer look at how these toxins function, they are more similar than suggested by the diseases they cause. Symptoms of Tetanus vs. Symptoms of Botulism While tetanus causes a body to take a rigid, […]

January 28, 2019

By: List Labs

List Labs offers citations on our website for easy use by researchers.  At present we have over 3,000 citations from publications around the world, with emphasis on the last 5 years.  We provide information on how to purchase the referenced products and the ability to sort from among the over 100 catalog items we offer […]

December 10, 2018

By: List Labs

A fast, sensitive, specific and accurate detection method to determine active infection Dr. Nancy Shine (408) 874-1305 NShine@ListLabs.com [Campbell, CA, 11/29/2018] • Method to detect Anthrax before it’s deadly • Anthrax is a problem for livestock • Test method is both specific and sensitive for Anthrax • List Labs is looking to partner on this […]

October 2, 2018

By: List Labs

List Labs scours the internet monthly, looking for citations referencing our products. We are highly intrigued by, and love to investigate the different ways researchers use our products. Scientists world-wide have used our toxins for research and have produced interesting results. List Labs History of working with Botulinum Neurotoxin List Labs has developed sensitive assays […]

September 19, 2018

By: douano@listlabs.com

By: T.J. Smith The answer as to whether the botulinum neurotoxin (BoNT)-producing bacteria comprised six separate species required a complete revolution in microbial classification.  Up to the turn of the last century, bacterial differentiations were based on morphological characteristic and biochemical activities, known collectively as phenotypic characteristics.  However, the discovery of DNA as the ultimate […]

July 23, 2018

By: douano@listlabs.com

By: Mary N. Wessling, Ph.D. ELS In this blog we will unravel the terminology describing bacterial toxins. In general, there are at least three ways that bacterial toxins are described in the literature: by their biological designation—the genus and/or species from which they come by the origin of the toxin, either as innate to the […]

July 16, 2018

By: douano@listlabs.com

By: T.J. Smith Origins of Botulinum Toxin Types – relationships between toxins and the bacteria that produce them Soon after the discovery that botulism was caused by a toxin, multiple toxin types were identified. Initial characterizations were based mainly on serological differences, however other anomalies were noted, such as differences in toxicity, sensitivity or resistance […]

July 11, 2018

By: douano@listlabs.com

By: Karen Crawford, PhD. President, List Labs Staphylococcal enterotoxin type B (SEB) is a powerful player in the family of toxins; in scientific terms, a superantigen.  This enterotoxin binds to major histocompatibility complex (MHC) class II molecules on antigen-presenting cells and specific V-β chains of the T-cell receptors.  This interaction between the three molecules leads […]

June 22, 2018

By: douano@listlabs.com

By: Rachel Berlin, Marketing Manager Microbiome research is uncovering the enormous potential for developing drugs, such a live biotherapeutic products, from the microbiome.  This burgeoning field is the future of medicine. List Labs is excited and proud to support microbiome research by providing reagents to scientists studying the human microbiome. Below is a list of microbiome […]

May 29, 2018

By: douano@listlabs.com

By: T.J. Smith Following a botulism outbreak due to contaminated ham that severely sickened 10 and resulted in the death of three people in Ellezelles, Belgium, a review and case study on botulism was published by a researcher named Emile Van Ermengem (Van Ermengem 1897).  While Van Ermengem was not the first to study this […]

May 18, 2018

By: douano@listlabs.com

By: Rachel Berlin, Marketing Manager 1978 was a great year for scientific advancement – NASA hired the first women astronauts, the first test tube baby was born and List Labs was founded. Linda Shoer, our founder, saw an opportunity when she realized there was a need for a commercial supplier of Cholera Toxin for studies […]

April 9, 2018

By: douano@listlabs.com

By: Stacy Burns-Guydish, Ph.D., Senior Director, Production The terms “Microbiome” and “live biotherapeutics” have been repeated frequently in the last few years in scientific circles. Researchers are understanding more and more about the various microbiomes in the human body and how they affect our overall health. From this research, microorganisms have been identified that may […]

March 19, 2018

By: douano@listlabs.com

By: Mary N. Wessling, Ph.D. ELS List Biological Laboratories’ (List Labs) catalog of products is related to furthering research in human health and preventing disease, most commonly as the starting materials for vaccine research & development or production around the world. Vaccines are mainly identified for their capacity to prevent diseases that the body’s innate defensive […]

February 20, 2018

By: douano@listlabs.com

By: Nancy Shine, PhD, Director of R&D, List Labs A fast, sensitive, specific and accurate detection method to determine active infection by Bacillus anthracis in plasma has been developed at List Biological Laboratories. Bacillus anthracis is regarded as a major biological warfare threat. The inhalation form of Bacillus anthracis infection can kill quickly.  While antibiotic […]

January 23, 2018

By: douano@listlabs.com

By: Rachel Berlin, Marketing Manager List Labs is proud to be exhibiting at ASM Biothreats February 12-14th. The conference will be held in Baltimore, Maryland at the Hilton Hotel. Thought leaders in academia, industry and government will gather to present and discuss the latest developments in the emerging field of biothreats. This year’s conference has […]

January 8, 2018

By: douano@listlabs.com

By: Rachel Berlin, Marketing Manager The List Labs website hosts a library of scientific article abstracts related to the research performed using our products called the Citations Page. Visitors can search this library to learn how others have used List Labs’ reagents in their research. This valuable resource is updated monthly with new articles from a wide variety […]

October 4, 2017

By: douano@listlabs.com

By: Shawn Lyles, Marketing Manager List Labs will be attending the 54th annual Interagency Botulism Research Coordinating Committee (IBRCC) this year from October 27-30th. The conference will be held in Ellicott City, MA at the Turf Valley Resort and Conference Center. This international forum presents state-of-the-art research on botulinum toxin and the deadly disease of […]

September 11, 2017

By: douano@listlabs.com

By: Rachel Berlin, Marketing Manager   Over 20 Scientific Posters Available on our website Scientific posters are a great way to visually display complex scientific issues. List Labs has a large list of scientific posters published on our website under the specific products they pertain to. We have been getting a lot of requests lately […]

August 29, 2017

By: douano@listlabs.com

By: Rachel Berlin, Marketing Manager Ordering List Labs’ Products Has Never Been Easier! Did you know that you could order List Labs’ products online? You must create an online account to purchase online from List Labs. For instructions on how to become a List Labs customer click here. The online ordering process has convenient features built in. […]

August 29, 2017

By: dpinkston@listlabs.com

The origin of businesses is often an interesting story. List Biological Laboratories is no exception. The company was founded in 1978 by Linda Shoer. Linda was an entrepreneurial scientist in Silicon Valley, who’d been relocated with her husband from Boston. She had an idea for a company and leveraged an initial order into a loan […]

July 17, 2017

By: douano@listlabs.com

By: Mary N. Wessling, Ph.D. ELS Tetanus Toxin’s Use as a Protein Carrier and Antigen Tetanus toxin (TT) is the major virulence factor of the Gram-positive bacterium Clostridium tetani. Infection with this bacterium in unvaccinated persons produces muscle spasms by binding to nerve endings and moving throughout the nervous system in a specific way. Eventually, […]

June 5, 2017

By: douano@listlabs.com

By: Mary N. Wessling, Ph.D. ELS   Cholera Toxin has Two Faces In 2010, Sanchez et al published an article with the puzzling title “Cholera toxin—A foe & a friend. ” The cholera toxin, a complex of two units produced by the pathogen Vibrio cholerae clearly plays the “foe” role [1]. The World Health Organization […]

March 27, 2017

By: douano@listlabs.com

By: Mary N. Wessling, Ph.D. ELS Cross-Reacting Materials: The Motor Behind Conjugate Vaccines Vaccines in history The history and practice of vaccination as protection against viral infection is often thought to begin with Edward Jenner’s discovery that  cowpox, a viral infection of cows, prevented smallpox in humans. However, it had long been suspected that survivors […]

March 13, 2017

By: douano@listlabs.com

By: Grace Ayabe, Technical Support Specialist List Labs recently launched a citation library in our website to provide you with research papers that utilize List Labs products; these papers can provide supplemental information for your research.  We currently have over 1800 citations, from around the world, available for viewing.  The number of available citations will […]

March 6, 2017

By: douano@listlabs.com

By: Md. Elias, Ph.D, Senior Scientist What are Endotoxins? Endotoxins (aka lipopolysaccharide, LPS or lipoglycan) are part of the outer membrane of Gram-negative bacteria consisting of a lipid moiety and a polysaccharide moiety, the latter is composed of an inner core, outer core and O-antigen joined by covalent bonds1. In animals the lipid part of […]

February 14, 2017

By: List Labs

By: Mary N. Wessling, Ph.D. ELS List Biological Laboratories, Inc.’s products are being used to confront one of the most pressing problems in health care today: stopping the worldwide spread of illness caused by Clostridium difficile (CD, C Difficile Toxin), a gram-positive, spore-forming anaerobic bacillus. The spores are highly resistant to adverse environmental conditions and are […]

December 12, 2016

By: List Labs

By: Suzanne Canada, Ph.D. Diphtheria toxin is an important tool used for selective killing (ablation) of cells for research purposes.  Using this technique, dubbed “toxin receptor–mediated cell knockout” when it was first used [1], researchers can selectively remove a specific type of cell in a live mouse without having to generate transgenic “knockout” animals, which […]

November 4, 2016

By: List Labs

By: M. Wessling A recently published study by Wen et al [1] provides an encouraging look at a possible therapy for the chronic neuro-inflammatory disease multiple sclerosis (MS). What is even more interesting is that this experimental autoimmune encephalitis myelitis (EAE) study, which used the List Labs Product #180 Pertussis Toxin in mice to induce autoimmune […]

August 15, 2016

By: douano@listlabs.com

By: Md. Elias, Ph.D, Senior Scientist List Labs is one of the leading manufacturers of high quality adjuvants from bacterial sources. Our highly purified adjuvants for research and development are Tetanus Toxoid (Product #191), Cholera Toxin B Subunit (Product #104), Diphtheria Toxin CRM197 Mutant (Product #149), Adenylate Cyclase Mutant, Cya-AC– (Product #198L), Pertusis Toxin Mutant (Product #184), […]

July 12, 2016

By: douano@listlabs.com

By: Nancy Shine, Ph.D., Director of Research & Development List Biological Laboratories, Inc. has designed a fluorescently labeled substrate for specific and quantitative detection of anthrax lethal factor in plasma. Bacillus anthracis is regarded as a major biological warfare threat. The inhalation form of Bacillus anthracis infection can kill quickly. While antibiotic treatment can clear […]

June 14, 2016

By: douano@listlabs.com

By: Debra Booth, VP of Operations Linda Eaton, Ph.D., VP of Research & Development Stacy Burns-Guydish, Ph.D., Senior Director of Microbiology PJ Nehil, Sales & Distribution Coordinator Dear Researchers Everywhere, List Labs recently exhibited at the 2016 BIO International Convention. As a producer of bacterial products for research, as well as a provider of custom […]

June 7, 2016

By: douano@listlabs.com

By: Dom C. Ouano, Marketing Coordinator Since List Labs introduced products in the Tetanus Toxin family more than 25 years ago, interest and knowledge in this field has multiplied. Tetanus Toxin C fragment, the non-toxic C-terminal domain of the heavy chain, is retrogradely transported to the central nervous system and is useful as a neuronal […]

May 16, 2016

By: douano@listlabs.com

UPDATE: July 13, 2016 Alpha Toxin from C. septicum, product #116L is now available for purchase online. Information on other potential upcoming products can be found on our Product Pipeline. UPDATE: May 16, 2016 Alpha Toxin from C. septicum is currently in late to final stages of development, and we are accepting orders now. We expect to ship […]

April 25, 2016

By: douano@listlabs.com

By: Karen Crawford, Ph.D., President In 1983, List Labs introduced Diphtheria Toxin to the research community. Researchers have purchased Diphtheria Toxin for various uses. One common use is cell ablation. The receptor for Diphtheria Toxin is also called heparin-binding EGF-like growth factor (HB-EGF). This receptor, located on several cell types, binds Diphtheria Toxin, allowing the toxin to enter […]

March 28, 2016

By: douano@listlabs.com

By: Dom C. Ouano, Marketing Coordinator Select Agents & Toxins (SA&T) require additional regulations during shipping. In 2015, it was reported in the media that a large institution neglected to ship SA&T’s properly. As a result of this, a much greater deal of scrutiny followed, and a major shipping service provider decided to keep Select Agents & […]

January 25, 2016

By: douano@listlabs.com

By: Grace Ayabe, Technical Support Would you like a positive control for production of cytokines in human peripheral blood mononuclear cells (PBMC’s)? If your laboratory is testing for cytokine production, List Labs can provide you with SEB (Staphylococcus aureus, Enterotoxin Type B) to stimulate a positive response to assure that your cells are functional. SEB […]

January 11, 2016

By: douano@listlabs.com

By: Md. Elias Ph.D, Senior Scientist Epsilon Toxin Linked to Multiple Sclerosis List Labs recently added Product #126A, pure Native C. perfringens Epsilon Toxin to its product line. Although Epsilon Toxin related pathology and disease are common in farm animals and rare in humans, recent studies suggest potential involvement of this toxin with Human Multiple Sclerosis (MS), an inflammatory […]

October 19, 2015

By: douano@listlabs.com

By: Dom C. Ouano, Marketing Associate Since 1978, List Labs has developed over 100 toxins and reagents for research. Our facility has BSL2 and BSL3 laboratories appropriate for the production of a wide variety of toxins, making safety and security top priorities. Therefore, we have processes in place that we must follow to comply with regulations. […]

August 10, 2015

By: douano@listlabs.com

By: Dom C. Ouano, Marketing Associate Debby Renshaw, Shipping Manager Kim Krause, Laboratory Support Supervisor Below is a list of recommended steps on handling List Labs products upon receiving them. It should be noted that these are simply our own suggestions. If your institution has a standard protocol in place, we ask that you follow said standard […]

June 22, 2015

By: douano@listlabs.com

By: Karen Crawford, Ph.D., President Eva Purro, Director of Quality Assurance Dom C. Ouano, Marketing While most of List Labs’ products are intended as research reagents (Research Grade), several can be produced as GMP products for use in humans. Below are key differences between the two. Research Only VS Preclinical/Clinical/Human Use Reagent grade products for […]

April 6, 2015

By: List Labs

By: Suzanne Canada, Ph.D. Tanager Medical Writing Concerns over outbreaks of potentially serious childhood diseases are in the news again in California with an increase in whooping cough infections in 2014, caused by the pathogen Bordetella pertussis, and a measles outbreak in December 2014 to February 2015.  Since outbreaks and epidemics may be infrequent, many […]

March 16, 2015

By: List Labs

By: Suzanne Canada, Ph.D. Tanager Medical Writing While you go about your day, you are surrounded by micro-organisms.  Although most of us spend a lot of time washing up and trying not to think about the propensity of creatures that share our personal space, scientists have been studying them.  Due to their great progress, we […]

March 9, 2015

By: douano@listlabs.com

Original Post By: Linda Eaton, Ph.D., VP of Research and Development Eva Purro, Director of Quality Assurance Updates by: Dom C. Ouano, Marketing 4-13-15 Cholera QD Product #9100B is now available for purchase online. Vial Size: 1 mg List Price: $550/vial Minimum order: 5 vials 4-8-15 Cholera QD Product #9100B is now available from stock. Vial Size: […]

January 26, 2015

By: List Labs

By: Suzanne Canada, Ph.D. Tanager Medical Writing An exciting report was released in October about a new class of targeted anti-tumor drugs, in which genetically engineered stem cells were used to deliver cytotoxins to brain tumors.1 Brain cancers known as glioblastomas (GBM) are notoriously difficult to treat because the tumors often re-grow after surgery and because […]

January 12, 2015

By: List Labs

Fundastic believes in being objective and transparent when it comes to funding and financing for small businesses. The following is an interview between Fundastic writer Sarah Tang and List Labs President Dr. Karen Crawford. View the original post here. By: Sarah Tang Fundastic Business Owner Stories Dr. Karen Crawford is the president of List Labs, a manufacturing […]

January 5, 2015

By: List Labs

By: Suzanne Canada, Ph.D. Tanager Medical Writing   Three anthrax toxin components—Protective antigen (PA), edema factor (EF) and lethal factor (LF) are available for research purposes from LIST Biological Laboratories, separately at a high level of purification. At least two out of three of these components are necessary to enter a mammalian cell and exert […]

December 15, 2014

By: douano@listlabs.com

By: Karen Crawford, Ph.D. President, List Biological Laboratories, Inc.   Many bacterial products are potent immune system activators, helping our bodies identify and defend against microbial invasions.  The innate immune system or non-specific immune system is found in animals as well as in plants, fungi and insects and is employed when pathogens break through the […]

October 21, 2014

By: List Labs

By: Suzanne Canada, Ph.D. Tanager Medical Writing   Vaccines have been used to help control diseases for more than 200 years and are the common practice for children and adults. Childhood vaccination has substantially reduced the morbidity and mortality from infectious diseases in much of the developed world, and influenza vaccinations have reduced the impact […]

September 30, 2014

By: douano@listlabs.com

Adenylate cyclase toxin-hemolysin (ACT, AC-Hly, or CyaA) is an important virulence factor for Bordetella pertussis.  Adenylate cyclase toxin is a large (178 kDa), 1,706-residue-long, toxin consisting of an amino-terminal adenylate cyclase (AC) domain of 400 residues and a repeat toxin (RTX) moiety of 1,306 residues.  Sequences within the RTX domain are responsible for target binding, pore-formation […]

July 28, 2014

By: List Labs

By: Suzanne Canada, Ph.D. Tanager Medical Writing   The world of microbial pathology is often understood as a system of various organisms who are trying to survive by using plants or animals as “hosts”. The dynamics of these systems can described the pathogen as trying to establish a living space for itself, while the “host” […]

July 21, 2014

By: List Labs

List Biological Laboratories, Inc. is pleased to announce a key addition to our Clostridium difficile Toxin A and Toxin B product line. Our new product, 155L is a liquid formulation of Toxin B. This product allows for the highest activity level of any of our C.difficile offerings and the most stability.  It already shows stability […]

July 17, 2014

By: dpinkston@listlabs.com

Volume Discounts on Toxins and Reagents List Laboratories has been in business since 1978.  We’ve been providing our customers with quality toxins and custom manufacturing services for decades.    We want to make it easier for everyone within your company to purchase and receive the best value for those purchases. We have recently begun a […]

June 17, 2014

By: dpinkston@listlabs.com

What is Lipopolysaccharide? Lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria, is a potent stimulator of the vertebrate innate immune system.  This innate immune system, mediated by macrophages and dendritic cells, generates a rapid response to infectious agents.  Structural patterns common to diverse LPS molecules are recognized by Toll-like receptors (TLR) and […]

May 14, 2014

By: dpinkston@listlabs.com

What is Clostridium Difficile? Clostridium difficile is the causative agent of antibiotic-associated diarrhea and pseudomembranous colitis.  It produces two major exotoxins, Toxin A and Toxin B; however, about 10% of strains isolated from patients with colitis also contain genes, coding for a unique ADP-ribosylating toxin, CDT Binary Toxin. Additionally, Clostridium difficile produces and secretes a glutamate […]

April 28, 2014

By: dpinkston@listlabs.com

What Are Toxin Neutralization Assays & How Do They Work? For clinical detection or vaccine testing, it is hard to beat a toxin neutralization assay.  Toxin neutralization assays (TNA) assess the ability of antibodies to protect cells in culture from the cytotoxic affect of the specific toxins.  Interestingly, these assays may be used for sensitive […]

April 21, 2014

By: List Labs

By: Suzanne Canada, Ph.D. Tanager Medical Writing Pertussis Infections (aka Whooping Cough) Increasing Rates of pertussis infection, commonly referred to as whooping cough, are on the upswing. Whooping cough is a highly contagious respiratory infection with flu-like symptoms including a blocked or runny nose, sneezing, mild fever and the distinctive, hack-like cough. Prior to the […]

April 14, 2014

By: douano@listlabs.com

By: Karen Crawford, Ph.D. President, List Biological Laboratories, Inc.   You hear about Clostridium difficile at your doctor’s office and in news articles, but what does it mean and how does it affect the world around us? C. Difficile Statisitcs C. Difficile Mortality Rates: Complications from C. difficile infection (CDI) have become an increasing patient safety concern […]

April 7, 2014

By: dpinkston@listlabs.com

  List Biological Laboratories, Inc. (List) actively supports and participates in the BabyBIG® project. What is BabyBIG® ? BabyBIG® (Human Botulism Immune Globulin; BIG-IV) is a public service, not-for-profit orphan drug manufactured and distributed by the California Department of Public Health.It is the only therapy available for infants who are infected with the organism that causes […]

March 18, 2014

By: dpinkston@listlabs.com

Shiga Toxins May be Purchased without Government Approval The CDC has removed Shiga toxins (Stx1 and Stx2) from the list of materials requiring oversight.  As a result, Shiga Toxins are no longer classified as select agents and may be purchased without government approval for your research and investigative needs.   While Shiga toxins carry fewer restrictions, […]