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Diphtheria Toxin for Research – Infographic

October 17, 2019

By: List Labs

List Labs currently has over 3300 citations with more being added every month! Within our citations page, we provide the ability to search and sort from over 100 cataloged items that are offered here.

We are honored to supply researchers worldwide with highly purified bacterial toxins that can potentially be instrumental in helping to change the world!

In this post, we’ve gathered all of our current citations for our Diphtheria product group. Please use these citations as a reference and resource for your potentially life-changing work!

Diphtheria Toxin & CRM

Corynebacterium diphtheriae is a Gram-positive, bacterium which infects epithelial cells of the upper respiratory tract and produces diphtheria toxin.  Diphtheria toxin is proteolytically cleaved forming a two part toxin, held together by a disulfide bridge.  The amino-terminal carries the toxin’s enzymatic activity, capable of ADP-ribosylation and inactivation of translation elongation factor 2 (EF-2).  The carboxy-terminal domain binds to specific host receptors, the heparin-binding EGF-like growth factor (HB-EGF) on human epithelial cells and translocates the catalytic domain into the cell.  After binding to the cell receptor, the diphtheria toxin is taken up by endocytosis, the pH of the endocytic vesicle drops, and the translocation region of the toxin helps guide the catalytic domain into the host cytoplasm where it is released.  Within the cytoplasm, the diphtheria toxin catalytic domain ADP ribosylates EF-2, terminating protein synthesis and causing the death of the cell.  Diphtheria toxin is highly potent, and as little as one catalytic domain is thought to cause cell death.  In cell culture, diphtheria toxin inhibits protein synthesis and causes death in cells carrying the HB-EGF receptor.  This toxin has been used to specifically eliminate receptor-expressing cells in transgenic mice.

View List Labs Diphtheria toxins for sale.

View some of List Labs Diphtheria related blogs:

Bacterial Toxin Terminology

Toxoids, Toxins and Vaccine Related Terminology

List Labs Reagents Used in Research – January ’18

Carrier Protein Used in Life-Changing Research

Cell Ablation Using Diphtheria Toxin (DT) is an Important Technique for Studying Regeneration in Living Animals

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