Tetanus Toxin, a Vaccine Adjuvant and More
June 7, 2016
By: Dom C. Ouano, Marketing Coordinator
Since List Labs introduced products in the Tetanus Toxin family more than 25 years ago, interest and knowledge in this field has multiplied. Tetanus Toxin C fragment, the non-toxic C-terminal domain of the heavy chain, is retrogradely transported to the central nervous system and is useful as a neuronal tracer and a biological carrier. It is also reported to have neuroprotective effects in mice, providing protection against methamphetamine induced neurotoxicity and motor impairment. Tetanus Toxin is used in an animal model of temporal lobe epilepsy, and Tetanus Toxoid is a recall (memory) antigen for activation of peripheral blood mononuclear cells (PBMC). Tetanus Toxoid is used as a carrier protein for glycoconjugate vaccines, and acts as a vaccine adjuvant stimulating protective immune responses.
List Labs offers Tetanus Toxin C-Fragment from Clostridium tetani in 10ug vials (Product #193). Tetanus Toxin C-Fragment from Clostridium tetani, FITC Conjugate is available in 10ug vials (Product #196A). Tetanus Toxin from Clostridium tetani (Product #190) is available in either 25ug (#190A) or 100ug (#190B) vials. Tetanus Toxoid from Clostridium tetani (Product #191) is available in either 25ug (#191A) or 100ug (#191B) vials. Learn about our entire family of Tetanus products here.