Epsilon Toxin: A Fascinating Pore Forming Toxin That Crosses The Blood Brain Barrier
January 11, 2016
By: Md. Elias Ph.D, Senior Scientist
Epsilon Toxin Linked to Multiple Sclerosis
List Labs recently added Product #126A, pure Native C. perfringens Epsilon Toxin to its product line. Although Epsilon Toxin related pathology and disease are common in farm animals and rare in humans, recent studies suggest potential involvement of this toxin with Human Multiple Sclerosis (MS), an inflammatory disease of the CNS currently affecting 2.5 million people worldwide with diverse neurological symptoms such as autonomic, motor, and sensory problems.
Epsilon Toxin used in Cell Signaling
Aside from this toxin’s pathologic significance to understand and treat MS, it can be used as valuable reagent and tool in the field of cell signaling. Unlike other inhibitory neurotoxins, Epsilon Toxin can be used to stimulate dopamine and glutametargic neurons. The toxin has been shown to be sensitive to MDCK cells and bind to the brain endothelial cells. Epsilon Toxin has been reported to be used as delivery vehicle to facilitate the transport of drugs through the blood brain barrier for the treatment of experimental malignant brain tumors in mice. Epsilon toxin is also classified as a category B bio-threat agent by the CDC due to its potent toxicity and potential for malice and the purified epsilon toxin will be a valuable reagent in vaccine development and bio-defense research.
Epsilon Toxin is controlled by the US Department of Commerce and an export license is required for international shipments. However, it is not one of the Select Agents & Toxins regulated by the CDC and the USDA.
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