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Anthrax Lethal Factor (LF-A), Recombinant from B. anthracis Native Sequence

Anthrax Lethal Factor (LF-A), Recombinant from B. anthracis Native Sequence

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Products are for research purposes only and are
not for use in humans or as diagnostic agents.

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#169L (Liquid)

Clear

Technical Info

Certificate Of Analysis

N-HAZ

Purity

≥95%

Form

liquid

Storage temp

-20°C

Additional information

Weight 8 lbs
Dimensions 11 × 9 × 10 in
Destination

,

We have 22 citations
NLRP1B is an integrated decoy that subverts Shigella flexneri E3 ligase activity to promote effector-triggered immunity
Chung, Hudson, Stromberg et al
Proc Natl Acad Sci U S A (2026) 123 (13), e2514645123 DOI: 10.1073/pnas.2514645123
Snippet: 4 μg/mL LeTx (4 μg/mL Lethal factor protease + 4 μg/mL Protective Antigen) (LIST Labs), or 1% triton 100. At harvest, 35 μL of supernatant was collected for LDH activity assay. …
Single-molecule sensing with an anthrax nanopore enabled by pH-asymmetric ionic liquids
Zhang, Wang, Zhou et al
J Nanobiotechnology (2025) 23 (1), 747 DOI: 10.1186/s12951-025-03817-w
Cited by 7
FigureFigureFigure
A Lyophilizable Nanoparticle Vaccine Specific for a Novel Linear Neutralizing Epitope in the α2-α3 Helices of Domain 3 of Lethal Factor from Bacillus anthracis
Oscherwitz, Cease, Milich et al
Toxins (Basel) (2025) 17 (8) DOI: 10.3390/toxins17080422
Cited by 1
Snippet: ors can be pre-incubated with LeTx to prevent the cytotoxicity of the LeTx on the susceptible RAW264.7 macrophage target cell line. For neutralization studies, approximately 120 ng/mL of PA (PA 171E, List Labs, Campbell, CA, USA) and 40 ng of LF (LF169L, List Labs, Campbell, CA, USA) were used in the TNA. Contemporaneous toxin dose 50% (TD50) were separately determined for PA and LF with each TNA
FigureFigureFigure
A Lyophilizable Nanoparticle Anthrax Vaccine Targeting the Loop-Neutralizing Determinant in Protective Antigen from Bacillus anthracis
Oscherwitz, Cease, Milich et al
Microorganisms (2025) 13 (8) DOI: 10.3390/microorganisms13081878
Cited by 1
Snippet: ... For neutralization studies, approximately 120 ng/mL of PA (PA 171E, List Labs, Campbell, CA, USA) and 25 ng LF (LF169L, List Labs, Campbell, CA, USA) were used in the TNA. Contemporaneous toxin dose 50% (TD50) was determined for PA and LF with each assay to validate ...
FigureFigureFigure
Serological correlates of protection and long-term efficacy of a novel recombinant protective antigen-based anthrax vaccine in a rabbit model
Kim, Pyo, Kim et al
Vaccine (2025) 57, 127212 DOI: 10.1016/j.vaccine.2025.127212
Snippet: … Toxin neutralization activity assay ?These were mixed with anthrax lethal toxin (500 ng/mL PA and 100 ng/mL lethal factor [LF]; List Biologicals, USA) in a separate 96-well microtiter plate at equal volumes and incubated for 30 min. For long-term immunogenicity evaluation, TNA was performed using anthrax lethal toxin at concentrations of 100 ng/mL PA and 80 ng/mL LF. …
The Anthrax Toxin Lethal Factor in Solution Does Not Have the Protein’s Crystallized Structure
Rubinson, Kasianowicz
Toxins (2025) 17 (4), 157 DOI: 10.3390/toxins17040157
Snippet: - … The List Biological Laboratories' recombinant LF used here has two additional residues (histidine and methionine) on the N-terminal, giving it a molecular mass of 90.49 …
Shigella OspF blocks rapid p38-dependent priming of the NAIP-NLRC4 inflammasome
Turcotte, Kim, Eislmayr et al
bioRxiv (2025)
Cited by 4
Snippet:

PA Delivery

Anthrax Lethal Factor protease is delivered into cells via co-administration with protective antigen (PA). Cells were treated with 2 µg/mL PA (List Labs, 171E) only as a control, or 2 µg/mL PA + 1 µg/mL Lethal Factor (List Labs, 169L).

FigureFigureFigure
Label-Free Nanopore Observation on Regulation of Endopeptidase Activity of Anthrax Lethal Factor
Li, Wang, Zhang et al
SSRN Journal (2022)
Snippet:

2.1 Materials and Chemicals

... The aLF was ordered from List Biological Laboratories, Inc (Listlabs, US). ...

2.2 The Preparation of aLF Proteolytic Reaction

aLF, ZnCl2 and peptide substrate were mixed together as proteolytic buffer (5.64 μM, 28 mM and 2.82 μM) for endopeptidase activity reaction, ...

Author did not specify which Lethal Factor (LF) was utilized; List Labs provides the following LF:

Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2+ DRG sensory neurons
Yang, Isensee, Neel et al
Nat Neurosci (2021)
Cited by 37
Snippet:

... LF was purchased from List Biological Laboratories (catalog no. 169, recombinant from B. anthracis). ...

Liposome-based nanocarriers loaded with anthrax lethal factor and armed with anti-CD19 VHH for effectively inhibiting MAPK pathway in B cells
Banihashemi, Rahbarizadeh, Zavaran Hosseini et al
Int Immunopharmacol (2021) 100, 107927 DOI: 10.1016/j.intimp.2021.107927
Cited by 15
Snippet:

... Anthrax Lethal Factor (LF-A) (#171E) and Anthrax Protective Antigen (PA) (#169L) were obtained from List Biological Laboratory (California, USA). ...

Showing 1-10 of 22 papers.
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