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A novel single-domain antibody obtained from immune Bactrian camels against botulinum toxin type A using SPR-based screening method
Heliyon
Hu, N;Peng, F;Jiang, Z;Wang, Z;Peng, S;Xing, C;Liu, Y;Li, X;Luo, L;Chen, G;Xiao, H;Wang, J;Yu, J;Liu, C;Qiao, C;Feng, J;
Product: Receptor for Clostridium botulinum Type A Neurotoxin, GST-SV2c luminal domain
Botulinum neurotoxin (BoNT) is a highly lethal toxin produced by the anaerobic bacterium Clostridium....
Investigations of Thiosemicarbazides as Botulinum Toxin Active-Site Inhibitors: Enzyme, Cellular, and Rodent Intoxication Studies
ACS Infectious Diseases
Patel, EN;Lin, L;Park, H;Sneller, MM;Eubanks, LM;Tepp, WH;Pellet, S;Janda, KD;
Product: SNAPtide® Peptide Substrate flP6(DABCYL/5-IAF) for C. botulinum Type A Neurotoxin
Botulinum neurotoxin type A (BoNT/A) is an exceptionally potent neurotoxin of great therapeutic valu....
Activity of botulinum neurotoxin X and its structure when shielded by a non-toxic non-hemagglutinin protein
Communications Chemistry
Martínez-Carranza, M;kerlová, J;Lee, PG;Zhang, J;Kr?, A;Sirohiwal, A;Burgin, D;Elliott, M;Philippe, J;Donald, S;Hornby, F;Henriksson, L;Masuyer, G;Kaila, VRI;Beard, M;Dong, M;Stenmark, P;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
Botulinum neurotoxins (BoNTs) are the most potent toxins known and are used to treat an increasing n....
Reward history cues focal attention in whisker somatosensory cortex
Biorxiv
Ramamurthy, D;Rodriguez, L;Cen, C;Li, S;Chen, A;Feldman, D;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
The history of stimuli and rewards in the recent past drives an automatic form of attention in anima....
Retrograde adenosine/A2A receptor signaling facilitates excitatory synaptic transmission and seizures
Cell Reports
Nasrallah, K;Berthoux, C;Hashimotodani, Y;Chávez, AE;Gulfo, MC;Luján, R;Castillo, PE;
Product: Botulinum Neurotoxin Type B Light Chain, Recombinant
Retrograde signaling at the synapse is a fundamental way by which neurons communicate and neuronal c....
Facile detection of botulinum neurotoxin using LSPR nanosensor based on Langmuir-Blodgett films of gold nanoparticles
RSC Advances
Huong, NT;Nhiem, LT;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
In this exploratory study, Langmuir-Blodgett (LB) films of gold nanoparticles (Au NPs) were utilized....
Glycan-modified cellular nanosponges for enhanced neutralization of botulinum toxin
Biomaterials
Ai, X;Wang, D;Noh, I;Duan, Y;Zhou, Z;Mukundan, N;Fang, RH;Gao, W;Zhang, L;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
Botulinum toxin (BoNT) is a potent neurotoxin that poses a significant threat as a biowarfare weapon....
VIP interneurons in sensory cortex encode sensory and action signals but not direct reward signals
Current Biology
Ramamurthy, DL;Chen, A;Zhou, J;Park, C;Huang, PC;Bharghavan, P;Krishna, G;Liu, J;Casale, K;Feldman, DE;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
Vasoactive intestinal peptide (VIP) interneurons in sensory cortex modulate sensory responses based ....
Botulinum neurotoxin type A does not exert concentration-dependent effects on equine articular cartilage in vitro
American Journal Of Veterinary Research
McCarthy, MB;Duesterdieck-Zellmer, KF;Larson, MK;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
To determine whether Botulinum neurotoxin type A (BoNT-A) ameliorates the effects of interleukin 1 (....
Novel Glycolipid Chips with a Double Layer of Au Nanoparticles for Biological Toxin Detection
ACS Omega
Uzawa, H;Nagatsuka, T;Seto, Y;Nishida, Y;Saito, M;Tamiya, E;
Product: Botulinum Neurotoxin Type A Heavy Chain, Recombinant, Binding Domain
Glycolipid chips having a double layer of Au nanoparticles are proposed for detection of biological ....
A Preclinical Study Comparing the Activity and Potency of OnabotulinumtoxinA and PrabotulinumtoxinA
Clinical, Cosmetic And Investigational Dermatology
Rupp, DC;Canty, D;Rhéaume, C;Sondergaard, B;Niño, C;Broide, RS;Brideau-Andersen, AD;
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
The goal of this study was to compare the unit-to-unit biological activity of the vacuum-dried formu....
Transformation of a Metal Chelate into a Catch and Anchor Inhibitor of Botulinum A Protease
International Journal Of Molecular Sciences
Lin, L;Patel, E;Nielsen, A;Turner, L;Tepp, W;Nguyen, K;Pellett, S;Janda, K;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
Targeting the botulinum neurotoxin light chain (LC) metalloprotease using small-molecule metal chela....
Structure and activity of botulinum neurotoxin X
Biorxiv : The Preprint Server For Biology
MartÃnez-Carranza, M;Âkerlová, J;Lee, PG;Zhang, J;Burgin, D;Elliott, M;Philippe, J;Donald, S;Hornby, F;Henriksson, L;Masuyer, G;Beard, M;Dong, M;Stenmark, P;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
Botulinum neurotoxins (BoNTs) are the most potent toxins known and are used to treat an increasing n....
Tuning instability of non-columnar neurons in the salt-and-pepper whisker map in somatosensory cortex
Nature Communications
Wang, HC;LeMessurier, AM;Feldman, DE;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
Rodent sensory cortex contains salt-and-pepper maps of sensory features, whose structure is not full....
Nociceptor neurons affect cancer immunosurveillance
Nature
Balood, M;Ahmadi, M;Eichwald, T;Ahmadi, A;Majdoubi, A;Roversi, K;Roversi, K;Lucido, CT;Restaino, AC;Huang, S;Ji, L;Huang, KC;Semerena, E;Thomas, SC;Trevino, AE;Merrison, H;Parrin, A;Doyle, B;Vermeer, DW;Spanos, WC;Williamson, CS;Seehus, CR;Foster, SL;Dai, H;Shu, CJ;Rangachari, M;Thibodeau, J;V Del Rincon, S;Drapkin, R;Rafei, M;Ghasemlou, N;Vermeer, PD;Woolf, CJ;Talbot, S;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
Solid tumours are innervated by nerve fibres that arise from the autonomic and sensory peripheral ne....
Investigation of Salicylanilides as Botulinum Toxin Antagonists
ACS Infectious Diseases
Patel, EN;Lin, L;Sneller, MM;Eubanks, LM;Tepp, WH;Pellett, S;Janda, KD;
Product: SNAPtide® Peptide Substrate flP6(DABCYL/5-IAF) for C. botulinum Type A Neurotoxin
Botulinum neurotoxin serotype A (BoNT/A) is recognized by the Centers for Disease Control and Preven....
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
Botulinum neurotoxin A (BoNT/A), which causes botulism, is the most potent toxin known. Intoxication....
Recombinant botulinum neurotoxin serotype A1 in vivo characterization
Pharmacology Research & Perspectives
Périer, C;Martin, V;Cornet, S;Favre-Guilmard, C;Rocher, MN;Bindler, J;Wagner, S;Andriambeloson, E;Rudkin, B;Marty, R;Vignaud, A;Beard, M;Lezmi, S;Kalinichev, M;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
Clinically used botulinum neurotoxins (BoNTs) are natural products of Clostridium botulinum. A novel....
Human sensorimotor organoids derived from healthy and amyotrophic lateral sclerosis stem cells form neuromuscular junctions
Nature Communications
Pereira, JD;DuBreuil, DM;Devlin, AC;Held, A;Sapir, Y;Berezovski, E;Hawrot, J;Dorfman, K;Chander, V;Wainger, BJ;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
Human induced pluripotent stem cells (iPSC) hold promise for modeling diseases in individual human g....
Botulinum Toxin as an Ultrasensitive Reporter for Bacterial and SARS-CoV-2 Nucleic Acid Diagnostics
Biosensors And Bioelectronics
Song, F;Shen, Y;Wei, Y;Yang, C;Ge, X;Wang, A;Li, C;Wan, Y;Li, J;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
The rapid identification of pathogenic microorganisms plays a crucial role in the timely diagnosis a....
Wrinkle in Time: Development of Botulinum Neurotoxin Light Chain a Inhibitors through Structure Activity Relationship Studies
Thesis
Ku, A;
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
The botulinum neurotoxin serotype A (BoNT/A) is the deadliest toxin known to man with a lethal dose ....
Keratinocytes communicate with sensory neurons via synaptic-like contacts
Annals of Neurology
Talagas, M;Lebonvallet, N;Leschiera, R;Sinquin, G;Elies, P;Haftek, M;Pennec, JP;Ressnikoff, D;La Padula, V;Garrec, RL;L'herondelle, K;Mignen, O;Le Pottier, L;Kerfant, N;Reux, A;Marcorelles, P;Misery, L;
Product: Botulinum Neurotoxin Type C Light Chain, Recombinant
Pain, temperature and itch are conventionally thought to be exclusively transduced by the intraepide....
Catch and Anchor Approach To Combat Both Toxicity and Longevity of Botulinum Toxin A
Journal of Medicinal Chemistry
Lin, L;Olson, ME;Sugane, T;Turner, LD;Tararina, MA;Nielsen, AL;Kurbanov, EK;Pellett, S;Johnson, EA;Cohen, SM;Allen, KN;Janda, KD;
Product: SNAPtide® Peptide Substrate flP6(DABCYL/5-IAF) for C. botulinum Type A Neurotoxin
Botulinum neurotoxins have remarkable persistence (?weeks to months in cells), outlasting the small-....
OnabotulinumtoxinA Displays Greater Biological Activity Compared to IncobotulinumtoxinA, Demonstrating Non-Interchangeability in Both In Vitro and In Vivo Assays
Toxins
Rupp, D;Nicholson, G;Canty, D;Wang, J;Rhaume, C;Le, L;Steward, LE;Washburn, M;Jacky, BP;Broide, RS;Philipp-Dormston, WG;Brin, MF;Brideau-Andersen, A;
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
Differences in botulinum neurotoxin manufacturing, formulation, and potency evaluation can impact do....
Optimization of the rat digit abduction score (DAS) assay: Evaluation of botulinum neurotoxin activity in the gastrocnemius lateralis, peronei, and extensor digitorum longus
Toxicon: X
Cornet, S;Prier, C;Kalinichev, M;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
The mouse digit abduction score (DAS) assay is commonly used to measure muscle flaccidity-inducing e....
Piezo1/2 mediate mechanotransduction essential for bone formation through concerted activation of NFAT-YAP1–catenin
Elife
Zhou, T;Gao, B;Fan, Y;Liu, Y;Feng, S;Cong, Q;Zhang, X;Zhou, Y;Yadav, PS;Lin, J;Wu, N;Zhao, L;Huang, D;Zhou, S;Su, P;Yang, Y;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
Mechanical forces are fundamental regulators of cell behaviors. However, molecular regulation of mec....
The use of the dynamic weight bearing test to assess the effects of acute, intramuscularly administered botulinum neurotoxin type A1 in rats
Toxicon: X
Cornet, S;Prier, C;Wagner, S;Andriambeloson, E;Pouzet, B;Kalinichev, M;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
Assessing the efficacy of botulinum neurotoxin (BoNT) _in vivo_ is essential given the growing numbe....
Gut-Innervating Nociceptor Neurons Regulate Peyer’s Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense
Cell
Lai, NY;Musser, MA;Pinho-Ribeiro, FA;Baral, P;Jacobson, A;Ma, P;Potts, DE;Chen, Z;Paik, D;Soualhi, S;Yan, Y;Misra, A;Goldstein, K;Lagomarsino, VN;Nordstrom, A;Sivanathan, KN;Wallrapp, A;Kuchroo, VK;Nowarski, R;Starnbach, MN;Shi, H;Surana, NK;An, D;Wu, C;H
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
Gut-innervating nociceptor sensory neurons respond to noxious stimuli by initiating protective respo....
Botulinum toxin A injection into the entopeduncular nucleus improves dynamic locomotory parameters in hemiparkinsonian rats
Plos One
Tsang, AR;Rajakumar, N;Jog, MS;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
Parkinson’s disease is associated with hyperactivity of the subthalamic nucleus (STN), contrib....
The role of human serum albumin and neurotoxin associated proteins in the formulation of BoNT/A products
Toxicon : Official Journal Of The International Society On Toxinology
Kutschenko, A;Bigalke, H;Wegner, F;Wohlfarth, K;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
Botulinum neurotoxin (BoNT) is synthesized as a progenitor toxin complex (PTC) by Clostridium botuli....
Botulinum neurotoxin serotype D – a potential treatment alternative for BoNT/A and B non-responding patients
Clinical Neurophysiology
Kutschenko, A;Weisemann, J;Kollewe, K;Fiedler, T;Alvermann, S;Bselt, S;Escher, C;Garde, N;Gingele, S;Kaehler, S;Karatschai, R;Krger, T;Sikorra, S;Tacik, P;Wegner, F;Wollmann, J;Bigalke, H;Wohlfarth, K;Rummel, A;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
Botulinum neurotoxin serotypes A and B (BoNT/A & B) are highly effective medicines to treat hype....
SERS Detection of Clostridium botulinum Neurotoxin Serotypes A and B in Buffer and Serum: Towards the Development of a Biodefense Test Platform
Analytica Chimica Acta: X
Lim, C;Granger, J;Porter, M;
Product: Anti-Botulinum Neurotoxin, Type A (Mouse lgG monoclonal F1-40), Frozen Liquid
Botulinum neurotoxins (BoNTs) are classified at a highest degree of threat in biodefense, due largel....
Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection
Cell
Pinho-Ribeiro, FA;Baddal, B;Haarsma, R;O'Seaghdha, M;Yang, NJ;Blake, KJ;Portley, M;Verri, WA;Dale, JB;Wessels, MR;Chiu, IM;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
The nervous system, the immune system, and microbial pathogens interact closely at barrier tissues. ....
Purification and Characterization of Recombinant Botulinum Neurotoxin Serotype FA, Also Known as Serotype H
Toxins
Hackett, G;Moore, K;Burgin, D;Hornby, F;Gray, B;Elliott, M;Mir, I;Beard, M;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
We have purified and characterized recombinant botulinum neurotoxin serotype FA (BoNT/FA). This prot....
The Effect of Botulinum Neurotoxin Serotype a Heavy Chain on the Growth Related Proteins and Neurite Outgrowth after Spinal Cord Injury in Rats
Toxins
Wang, YF;Liu, F;Lan, J;Bai, J;Li, XQ;
Product: Botulinum Neurotoxin Type A Heavy Chain, Recombinant, Binding Domain
(1) Background: The botulinum toxin A (BoNT-A) heavy chain (HC) can stimulate the growth of primary ....
Field-deployable rapid multiple biosensing system for detection of chemical and biological warfare agents
Microsystems & Nanoengineering
Saito, M;Uchida, N;Furutani, S;Murahashi, M;Espulgar, W;Nagatani, N;Nagai, H;Inoue, Y;Ikeuchi, T;Kondo, S;Uzawa, H;Seto, Y;Tamiya, E;
Product: Botulinum Neurotoxin Type A Heavy Chain, Recombinant, Binding Domain
We also evaluated our device for the detection of pathogen agents from the air sample using the inst....
Differential endopeptidase activity of different forms of type A botulinum neurotoxin: A unique relationship between the size of the substrate and activity of the enzyme
Toxicon : Official Journal Of The International Society On Toxinology
Ambrin, G;Kumar, R;Singh, BR;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
Botulinum neurotoxins (BoNTs; serotypes A-G) are metalloproteases, which cleave and inactivate cellu....
Bioreactor model of neuromuscular junction with electrical stimulation for pharmacological potency testing
Integrative Biology : Quantitative Biosciences From Nano To Macro
Charoensook, SN;Williams, DJ;Chakraborty, S;Leong, KW;Vunjak-Novakovic, G;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
In vitro models of the neuromuscular junction (NMJ) are emerging as a valuable tool to study synapto....
High Yield Preparation of Functionally Active Catalytic-Translocation Domain Module of Botulinum Neurotoxin Type A That Exhibits Uniquely Different Enzyme Kinetics
The Protein Journal
Dhaliwal, HK;Thiruvanakarasu, N;Kumar, R;Patel, K;Ambrin, G;Cai, S;Singh, BR;
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
Botulinum neurotoxins (BoNTs) are the most toxic proteins known to cause flaccid muscle paralysis as....
LTP at Hilar Mossy Cell-Dentate Granule Cell Synapses Modulates Dentate Gyrus Output by Increasing Excitation/Inhibition Balance
Neuron
Hashimotodani, Y;Nasrallah, K;Jensen, KR;Chvez, AE;Carrera, D;Castillo, PE;
Product: Botulinum Neurotoxin Type B Light Chain, Recombinant
Excitatory hilar mossy cells (MCs) in the dentate gyrus receive inputs from dentate granule cells (G....
Promotion of endocytosis efficiency through an ATP-independent mechanism at rat calyx of held terminals
The Journal Of Physiology
Yue, HY;Bieberich, E;Xu, J;
Product: Botulinum Neurotoxin Type C Light Chain, Recombinant
Neurotransmission relies on membrane endocytosis to maintain vesicle supply and membrane stability. ....
Insights into the Mechanisms by Which Clostridial Neurotoxins Discriminate between Gangliosides
Biochemistry
Burns, JR;Lambert, GS;Baldwin, MR;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
Botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) are the causative agents of the paralyti....
Newly Designed Quinolinol Inhibitors Mitigate the Effects of Botulinum Neurotoxin A in Enzymatic, Cell-Based, and ex Vivo Assays
Journal of Medicinal Chemistry
Bremer, PT;Adler, M;Phung, CH;Singh, AK;Janda, KD;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
Botulinum neurotoxin A (BoNT/A) is one of the most deadly toxins and is the etiological agent of the....
Point-of-need detection using surface-based biosensors with an examination of protein immobilization and development of magnetic labels
Thesis
Lim, CYL;
Product: Botulinum Neurotoxin Type A Toxoid from Clostridium botulinum
Bithionol blocks pathogenicity of bacterial toxins, ricin, and Zika virus
Scientific Reports
Leonardi, W;Zilbermintz, L;Cheng, LW;Zozaya, J;Tran, SH;Elliott, JH;Polukhina, K;Manasherob, R;Li, A;Chi, X;Gharaibeh, D;Kenny, T;Zamani, R;Soloveva, V;Haddow, AD;Nasar, F;Bavari, S;Bassik, MC;Cohen, SN;Levitin, A;Martchenko, M;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
Diverse pathogenic agents often utilize overlapping host networks, and hub proteins within these net....
Operation of a homeostatic sleep switch
Nature
Pimentel, D;Donlea, JM;Talbot, CB;Song, SM;Thurston, AJ;Miesenbck, G;
Product: Botulinum Neurotoxin Type C Light Chain, Recombinant
Sleep disconnects animals from the external world, at considerable risks and costs that must be offs....
High-Throughput Screening Uncovers Novel Botulinum Neurotoxin Inhibitor Chemotypes
ACS Combinatorial Science
Bompiani, KM;Cagli, D;Krutein, MC;Benoni, G;Hrones, M;Lairson, LL;Bian, H;Smith, GR;Dickerson, TJ;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
Botulism is caused by potent and specific bacterial neurotoxins that infect host neurons and block n....
In vitro potency determination of botulinum neurotoxin B based on its receptor-binding and proteolytic characteristics
Toxicology In Vitro
Wild, E;Bonifas, U;Klimek, J;Trsemeier, JH;Krmer, B;Kegel, B;Behrensdorf-Nicol, HA;
Product: Botulinum Neurotoxin Type B Light Chain, Recombinant
Botulinum neurotoxins (BoNTs) are the most potent toxins known. However, the paralytic effect caused....
Identification of small molecule inhibitors of botulinum neurotoxin serotype E via footprint similarity.
Bioorganic & Medicinal Chemistry
Zhou, Y;McGillick, BE;Teng, YG;Haranahalli, K;Ojima, I;Swaminathan, S;Rizzo, RC;
Product: SNAP Etide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type E Neurotoxin
Botulinum neurotoxins (BoNT) are among the most poisonous substances known, and of the 7 serotypes (....
A highly sensitive and simply operated protease sensor toward point-of-care testing
Analyst
Park, S;Shin, YM;Seo, J;Song, JJ;Yang, H;
Product: Botulinum Neurotoxin Type C Light Chain, Recombinant
Protease sensors for point-of-care testing (POCT) require simple operation, a detection period of le....
Retrograde transport of radiolabelled botulinum neurotoxin type A to the CNS after intradetrusor injection in rats
BJU Interntational
Papagiannopoulou, D;Vardouli, L;Dimitriadis, F;Apostolidis, A;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
To investigate the potential distribution of radiolabelled botulinum neurotoxin type A (BoNT/A) in t....
Utilizing Combined Methodologies to Define the Role of Plasma Membrane Delivery During Axon Branching and Neuronal Morphogenesis
Journal Of Visualized Experiments: JoVE
Winkle, CC;Hanlin, CC;Gupton, SL;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
During neural development, growing axons extend to multiple synaptic partners by elaborating axonal ....
Comparative studies on the immunological response to the live spore anthrax vaccine in goats and passive protection test in mice
Thesis
Phaswana, PH;
Product: Botulinum Neurotoxin Type B Light Chain, Recombinant
Rapid Microfluidic Assay for the Detection of Botulinum Neurotoxin in Animal Sera
Toxins
Babrak, L;Lin, A;Stanker, LH;McGarvey, J;Hnasko, R;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
Potent Botulinum neurotoxins (BoNTs) represent a threat to public health and safety. Botulism is a d....
Investigation of the substrate recognition mechanisms of botulinum neurotoxin and its application in detection and therapy development
Thesis
Guo, J;
Product: VAMPtide® Peptide Substrate (o-Abz/Dnp) Substrate for C. botulinum Type B Neurotoxin
Botulinum Neurotoxins: Qualitative and Quantitative Analysis Using the Mouse Phrenic Nerve Hemidiaphragm Assay (MPN)
Toxins
Bigalke, H;Rummel, A;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
The historical method for the detection of botulinum neurotoxin (BoNT) is represented by the mouse b....
Use of Monoclonal Antibodies in the Sensitive Detection and Neutralization of Botulinum Neurotoxin Serotype B
Toxins
Cheng, LW;Henderson, TD;Lam, TI;Stanker, LH;
Product: Botulinum Neurotoxin Type B Light Chain, Recombinant
Botulinum neurotoxins (BoNT) are some of nature’s most potent toxins. Due to potential food co....
Removal of Botulinum Neurotoxin a Surrogate from Reusable Medical Device Surfaces
Applied Biosafety
Lucas, AD;Di Prima, MA;Hitchins, VM;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
Botulinum neurotoxin A (BoNT/A) is on the national select agent registry and can be an extremely pot....
Computer-aided identification, synthesis, and biological evaluation of novel inhibitors for botulinum neurotoxin serotype A.
Bioorganic & Medicinal Chemistry
Teng, YH;Berger, WT;Nesbitt, NM;Kumar, K;Balius, TE;Rizzo, RC;Tonge, PJ;Ojima, I;Swaminathan, S;
Product: SNAP-25 Recombinant Protein Substrate for C. botulinum Types A and E Neurotoxin
Botulinum neurotoxins (BoNTs) are among the most potent biological toxin known to humans, and are cl....
Systematic discovery of molecular probes targeting multiple non-orthosteric and spatially distinct sites in the botulinum neurotoxin subtype A (BoNT/A)
Molecular And Cellular Probes
Dadgar, S;Floriano, WB;
Product: Botulinum Neurotoxin Type A Heavy Chain, Recombinant, Binding Domain
The development of molecular probes targeting proteins has traditionally relied on labeling compound....
Real-time and label-free analyte detection in a flow-through mode using immobilized fluorescent aptamer/quantum dots molecular switches
Biosensors and Bioelectronics
Bogomolova, A;Aldissi, M;
Product: Botulinum Neurotoxin Type B Light Chain, Recombinant
Inspired by the goal to create a biosensor with designer specificity for real-time detection of unla....
Nanopore sensing of botulinum toxin type B by discriminating an enzymatically cleaved Peptide from a synaptic protein synaptobrevin 2 derivative
ACS Applied Materials and Interfaces
Wang, Y;Montana, V;Grubii, V;Stout, RF;Parpura, V;Gu, LQ;
Product: Botulinum Neurotoxin Type B Light Chain, Recombinant
Botulinum neurotoxins (BoNTs) are the most lethal toxin known to human. Biodefense requires early an....
A simple, rapid and sensitive FRET assay for botulinum neurotoxin serotype B detection
PLoS ONE
Guo, J;Xu, C;Li, X;Chen, S;
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
Botulinum neurotoxins (BoNTs), the most potent naturally-occurring neurotoxins known to humans, comp....
High-throughput screening technologies for botulinum neurotoxins
Current Topics In Medicinal Chemistry
Bompiani, KM;Dickerson, TJ;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
Botulinum neurotoxins (BoNTs) are a class of bacterial neurotoxins that are the most potent toxic co....
Benzoquinones as inhibitors of botulinum neurotoxin serotype A
Bioorganic & Medicinal Chemistry
Bremer, PT;Hixon, MS;Janda, KD;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
Although botulinum neurotoxin serotype A (BoNT/A) is known for its use in cosmetics, it causes a pot....
Differential role of molten globule and protein folding in distinguishing unique features of botulinum neurotoxin
Biochimica et Biophysica Acta (BBA) - Proteins And Proteomics
Kumar, R;Kukreja, RV;Cai, S;Singh, BR;
Product: VAMPtide® Peptide Substrate (o-Abz/Dnp) Substrate for C. botulinum Type B Neurotoxin
Botulinum neurotoxins (BoNTs) are proteins of great interest not only because of their extreme toxic....
A novel Netrin-1-sensitive mechanism promotes local SNARE-mediated exocytosis during axon branching
The Journal of Cell Biology
Winkle, CC;McClain, LM;Valtschanoff, JG;Park, CS;Maglione, C;Gupton, SL;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
Developmental axon branching dramatically increases synaptic capacity and neuronal surface area. Net....
Product: Botulinum Neurotoxin Type B Light Chain, Recombinant
Synapses vary widely in the probability of neurotransmitter release. We tested the hypothesis that t....
A quantitative bifunctional in vitro potency assay for botulinum neurotoxin serotype A
Journal Of Pharmacological And Toxicological Methods
Gregory, RW;Werner, WE;Ruegg, C;
Product: Botulinum Neurotoxin Type A Heavy Chain, Recombinant, Binding Domain
Botulinum neurotoxin type A (BoNTA) is one of seven serotypes produced by Clostridium botulinum (typ....
Botulinum neurotoxin: unique folding of enzyme domain of the most-poisonous poison
Journal Of Biomolecular Structure And Dynamics
Kumar, R;Kukreja, RV;Li, L;Zhmurov, A;Kononova, O;Cai, S;Ahmed, SA;Barsegov, V;Singh, BR;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
Botulinum neurotoxin (BoNT), the most toxic substance known to mankind, is the first example of the ....
Identification of clinically viable quinolinol inhibitors of botulinum neurotoxin A light chain
Journal of Medicinal Chemistry
Cagli, D;Krutein, MC;Bompiani, KM;Barlow, DJ;Benoni, G;Pelletier, JC;Reitz, AB;Lairson, LL;Houseknecht, KL;Smith, GR;Dickerson, TJ;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
Botulinum neurotoxins (BoNT) are the most potent toxins known and a significant bioterrorist threat.....
A high-throughput-compatible FRET-based platform for identification and characterization of botulinum neurotoxin light chain modulators
Journal Of Visualized Experiments : JoVE
Cagli, D;Bompiani, KM;Krutein, MC;apek, P;Dickerson, TJ;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
Botulinum neurotoxin (BoNT) is a potent and potentially lethal bacterial toxin that binds to host mo....
Dynamin: Regulation of Vesicle Cycling and Resting Stability of Vesicles at Presynaptic Terminals
Thesis
Seymour, AB;
Product: Botulinum Neurotoxin Type B Light Chain, Recombinant
Bioluminescence assay for the highly sensitive detection of botulinum neurotoxin A activity
Analyst
Stevens, GB;Silver, DA;Zgaga-Griesz, A;Bessler, WG;Vashist, SK;Patel, P;Achazi, K;Strotmeier, J;Worbs, S;Dorner, MB;Dorner, BG;Pauly, D;Rummel, A;Urban, GA;Krueger, M;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
This article describes a novel bioluminescence assay for detecting the proteolytic activity of Botul....
Substrates and controls for the quantitative detection of active botulinum neurotoxin in protease-containing samples
Analytical Chemistry
Bagramyan, K;Kaplan, BE;Cheng, LW;Strotmeier, J;Rummel, A;Kalkum, M;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
Botulinum neurotoxins (BoNTs) are used in a wide variety of medical applications, but there is limit....
Noradrenaline is a stress-associated metaplastic signal at GABA synapses
Nature Neuroscience
Inoue, W;Baimoukhametova, DV;Fzesi, T;Wamsteeker Cusulin, JI;Koblinger, K;Whelan, PJ;Pittman, QJ;Bains, JS;
Product: Botulinum Neurotoxin Type C Light Chain, Recombinant
Exposure to a stressor sensitizes behavioral and hormonal responses to future stressors. Stress-asso....
Glucocorticoid feedback uncovers retrograde opioid signaling at hypothalamic synapses.
Nature Neuroscience
Wamsteeker Cusulin, JI;Fzesi, T;Inoue, W;Bains, JS;
Product: Botulinum Neurotoxin Type C Light Chain, Recombinant
Stressful experience initiates a neuroendocrine response culminating in the release of glucocorticoi....
Molecular assembly of botulinum neurotoxin progenitor complexes
PNAS
Benefield, DA;Dessain, SK;Shine, N;Ohi, MD;Lacy, DB;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
Botulinum neurotoxin (BoNT) is produced by Clostridium botulinum and associates with nontoxic neurot....
Femtogram-level detection of Clostridium botulinum neurotoxin type A by sandwich immunoassay using nanoporous substrate and ultra-bright fluorescent suprananoparticles
Biosensors and Bioelectronics
Bok, S;Korampally, V;Darr, CM;Folk, WR;Polo-Parada, L;Gangopadhyay, K;Gangopadhyay, S;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
We report a simple, robust fluorescence biosensor for the ultra-sensitive detection of Clostridium b....
Pocketed microneedles for rapid delivery of a liquid-state botulinum toxin A formulation into human skin
Journal of Controlled Release
Torrisi, BM;Zarnitsyn, V;Prausnitz, MR;Anstey, A;Gateley, C;Birchall, JC;Coulman, SA;
Product: Botulinum Neurotoxin Type A Toxoid from Clostridium botulinum
Botulinum toxin A (BT) is used therapeutically for the treatment of primary focal hyperhidrosis, a c....
Comparison of fluorigenic peptide substrates PL50, SNAPTide, and BoTest A/E for BoNT/A detection and quantification: exosite binding confers high-assay sensitivity.
Journal Of Biomolecular Screening
Ouimet, T;Duquesnoy, S;Poras, H;Fourni-Zaluski, MC;Roques, BP;
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
Detection and quantification of low doses of botulinum toxin serotype A (BoNT/A) in medicinal prepar....
New 9-aminoacridine derivatives as inhibitors of botulinum neurotoxins and P. falciparum malaria
Journal Of The Serbian Chemical Society
TOT, M;OPSENICA, DM;MITRIC, M;BURNETT, JC;GOMBA, L;BAVARI, S;OLAJA, BA;
Product: Botulinum Neurotoxin Type B Light Chain, Recombinant
Steroidal and adamantane aminoacridine derivatives were prepared and tested as both botulinum neurot....
Development of a fluorescence internal quenching correction factor to correct botulinum neurotoxin type A endopeptidase kinetics using SNAPtide
Analytical Chemistry
Feltrup, TM;Singh, BR;
Product: Unquenched Calibration Peptide for SNAPtide® 521 Substrate for C. botulinum Type A Neurotoxin
Botulinum neurotoxins (BoNTs), which are highly toxic proteins responsible for botulism, are produce....
Presynaptic Protein Interactions that Regulate Synaptic Strength at Crayfish Neuromuscular Junctions
Thesis
Prashad, RC;
Product: Botulinum Neurotoxin Type B Light Chain, Recombinant
Synapses vary widely in the probability of transmitter release. For instance, in response to an acti....
Metal ion-mediated inactivation and small molecule inhibition of the metalloprotease in botulinum neurotoxin A
Thesis
Feng, M;
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
Evaluation of Three VAMPtide Substrates for Botulinum Neurotoxin Type B
List Labs POSTER - Presented at the 49th Annual Interagency Botulinum Research Coordinating Committee Meeting, September 2012 in Baltimore Maryland
Shine, N.; Ouimet, T.
Product: VAMPtide® Peptide Substrate (o-Abz/Dnp) Substrate for C. botulinum Type B Neurotoxin
Background: Peptide substrates which are specific for Botulinum neurotoxin type B (BoNT/B) have been....
Sensitive and Specific Bifunctional Assay for Botulinum Neurotoxin Type A
List Labs POSTER - Presented at the 49th Annual Interagency Botulinum Research Coordinating Committee Meeting, September 2012 in Baltimore Maryland
Suryadi, K.; Christian, T.; Shine, N.
Product: Receptor for Clostridium botulinum Type A Neurotoxin, GST-SV2c luminal domain
Background: The purpose of this study is to develop a highly specific and sensitive method to assess....
Mechanisms of SNAP-25 Association with Botulinum Neurotoxin Light Chain A and SNARE Proteins
Thesis
Sultani, M;
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
Spontaneous transmitter release recruits postsynaptic mechanisms of long-term and intermediate-term facilitation in Aplysia
Proceedings Of The National Academy Of Sciences Of The United States Of America
Jin, I;Udo, H;Rayman, JB;Puthanveettil, S;Kandel, ER;Hawkins, RD;
Product: Botulinum Neurotoxin Type D Light Chain, Recombinant
Whereas short-term (minutes) facilitation at Aplysia sensory-motor neuron synapses is presynaptic, l....
Spontaneous transmitter release is critical for the induction of long-term and intermediate-term facilitation in Aplysia.
Proceedings Of The National Academy Of Sciences Of The United States Of America
Jin, I;Puthanveettil, S;Udo, H;Karl, K;Kandel, ER;Hawkins, RD;
Product: Botulinum Neurotoxin Type D Light Chain, Recombinant
Long-term plasticity can differ from short-term in recruiting the growth of new synaptic connections....
Development of highly sensitive chemiluminescence enzyme immunoassay based on the anti-recombinant HC subunit of botulinum neurotoxin type A monoclonal antibodies
Analytica Chimica Acta
Liu, Z;Song, C;Li, Y;Liu, F;Zhang, K;Sun, Y;Li, H;Wei, Y;Xu, Z;Zhang, C;Yang, A;Xu, Z;Yang, K;Jin, B;
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
Botulinum neurotoxins (BoNTs) are the most poisonous substances ever known. The early detection of t....
Longer-acting and highly potent chimaeric inhibitors of excessive exocytosis created with domains from botulinum neurotoxin A and B
The Biochemical Journal
Wang, J;Zurawski, TH;Bodeker, MO;Meng, J;Boddul, S;Aoki, KR;Dolly, JO;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
Various human neurogenic hyper-excitability disorders are successfully treated with type A or B BoNT....
Release, neuronal effects and removal of extracellular -nicotinamide adenine dinucleotide (-NAD) in the rat brain
The European Journal Of Neuroscience
Durnin, L;Dai, Y;Aiba, I;Shuttleworth, CW;Yamboliev, IA;Mutafova-Yambolieva, VN;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
Recent evidence supports an emerging role of -nicotinamide adenine dinucleotide (-NAD(+) ) as a nove....
An aptamer beacon responsive to botulinum toxins
Biosensors & Bioelectronics
Bruno, JG;Richarte, AM;Carrillo, MP;Edge, A;
Product: Botulinum Neurotoxin Type A from Clostridium botulinum
Sixty candidate DNA aptamers were developed against botulinum neurotoxin (BoNT) type A light chain (....
Sensitive Detection of Botulinum Neurotoxin Type A Using High Affinity Polyclonal Antibodies
List Labs POSTER - Presented at the 7th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins, Santa Fe, NM.
Suryadi, K.; Christian, T.; Shine, N.
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
Purpose of Study: The purpose of this study was to determine if a polyclonal antibody directed towar....
New SV2c Construct for Use in Binding and Detecting Botulinum Neurotoxin Type A
List Labs POSTER - Presented at the 7th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins, October 2011
Christian, T.; Suryadi, K.; Shine, N.
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
Purpose of Study:The purpose of this study was to express and purify the luminal domain loop of huma....
New FRET Substrate For Botulinum Neurotoxin Type A
List Labs POSTER - Presented at the 7th International Conference on Basic and Therapeutic Aspects of Botulinum and Tetanus Toxins, October 2011 Santa
Shine, N.; Suryadi, K.
Product: SNAPtide® Peptide Substrate (FITC/DABCYL) for C. botulinum Type A Neurotoxin
Purpose of Study: A new FRET peptide substrate for botulinum toxin type A (BoNT/A), marketed as SNAP....
Ultra Sensitive HPLC Detection Assay for Botulinum Neurotoxin Type A
List Labs POSTER - Presented at the 47th Annual Interagency Botulinum Research Coordinating Committee Meeting, November 2010, Atlanta, GA
Christian, T.; Suryadi, K.; Shine, N.
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
The botulinumneurotoxins are among the most potent toxins in nature. They are synthesized as single ....
Evaluation of a Small Peptide Inhibitor and A Control Peptide for Botulinum Neurotoxin, Type A
List Labs POSTER - Presented at the 47th Annual Interagency Botulinum Research Coordinating Committee Meeting, November 2010 in Atlanta, GA
Shine, N.; Suryadi, K.; Christian, T.
Product: SNAPtide® Peptide Substrate (o-Abz/Dnp) for C. botulinum Type A Neurotoxin
Botulinum neurotoxins are among the most toxic substances known to man. Four of the seven immunologi....
Characterization of SNARE Cleavage Products Generated by Formulated Botulinum Neurotoxin Type-A Drug Products
Toxins
Hunt T, Rupp D, Shimizu G, Tam K, Weidler J, Xie J.
Product: SYNTAXtide® (o-Abz/Dnp) Peptide Substrate for C. botulinum Type C Neurotoxin
The study evaluated substrate cleavage product(s) generated by three botulinum neurotoxin serotype A....
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