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Teixobactin: A Resistance-Evading Antibiotic for Treating Anthrax
ACS Infectious Diseases
Lawrence, WS;Peel, JE;de Winter, R;Ling, LL;Nitti, AG;Peoples, AJ;Shukla, R;MacGillavry, HD;Heine, HS;Hensel, ME;Whorton, EB;Weingarth, M;Lewis, K;Hughes, DE;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
The antimicrobial resistance (AMR) crisis has been associated with millions of deaths. Of particular....
Shigella OspF blocks rapid p38-dependent priming of the NAIP-NLRC4 inflammasome
Biorxiv : The Preprint Server For Biology
Turcotte, EA;Kim, K;Eislmayr, KD;Goers, L;Mitchell, PS;Lesser, CF;Vance, RE;
Product: Anthrax Lethal Factor (LF-A), Recombinant from B. anthracis Native Sequence
The NAIP-NLRC4 inflammasome senses pathogenic bacteria by recognizing the cytosolic presence of bact....
Discovery of Novel Nlrp3 Inhibitors Enabled by a High-Throughput Screen
SSRN
Dorich, S;Auger, A;Wang, L;Burch, J;Pellerin, C;Chan, S;Raymond, M;Zhang, L;Chefson, A;Germain, M;Jananji, S;Dumais, V;Gaudreault, S;Caron, A;Dumas-Bérube, É;Crackower, M;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
NLRP3 is a key regulator of the innate immune system involved in sensing a variety of pathogen and d....
DAG-MAG-ΒHB: A Novel Ketone Diester Modulates NLRP3 Inflammasome Activation in Microglial Cells in Response to Beta-Amyloid and Low Glucose AD-like Conditions
Nutrients
Gentili, V;Schiuma, G;Dilliraj, L;Beltrami, S;Rizzo, S;Lara, D;Giovannini, P;Marti, M;Bortolotti, D;Trapella, C;Narducci, M;Rizzo, R;
Product: Anthrax Lethal Factor (LF), Recombinant from B. anthracis
Background: A neuroinflammatory disease such as Alzheimer’s disease, presents a significant challeng....
Toxin and capsule production by Bacillus cereus biovar anthracis influence pathogenicity in macrophages and animal models
Plos Neglected Tropical Diseases
Jiranantasak, T;Bluhm, A;Chabot, D;Friedlander, A;Bowen, R;McMillan, I;Hadfield, T;Hartwig, A;Blackburn, J;Norris, M;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Bacillus cereus biovar anthracis (Bcbva) causes anthrax-like disease in animals, particularly in the....
Vaccinia virus F1Lblocks the ribotoxic stress response to subvert ZAK?-dependent NLRP1 inflammasome activation
European Journal Of Immunology
Szymanska, I;Bauernfried, S;Komar, T;Hornung, V;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Inflammasomes are essential for host defense, recognizing foreign or stress signals to trigger immun....
NLRP1B allele 2 does not respond to Val-boro-Pro (VbP) in the intestinal epithelium
Biorxiv
Mazzone, R;Winsor, N;Li, L;Barry, K;Ranger, A;Goyal, S;Meade, J;Bruce, J;Philpott, D;Mogridge, J;Girardin, S;
Product: Anthrax Lethal Factor (LF), Recombinant from B. anthracis
The intestinal mucosa must balance tolerance to commensal microbes and luminal antigens with rapid d....
NLRP1B expressed in intestinal epithelial cells is refractory to activation with Val-boro-Pro
Microbes And Infection
Mazzone, RJ;Winsor, NJ;Li, LY;Barry, KT;Ranger, A;Goyal, S;Meade, JJ;Bruce, J;Philpott, DJ;Mogridge, J;Girardin, SE;
Product: Anthrax Lethal Factor (LF), Recombinant from B. anthracis
The intestinal mucosa must balance tolerance to commensal microbes and luminal antigens with rapid d....
ROS-dependent S-palmitoylation activates cleaved and intact gasdermin D
Nature
Du, G;Healy, LB;David, L;Walker, C;El-Baba, TJ;Lutomski, CA;Goh, B;Gu, B;Pi, X;Devant, P;Fontana, P;Dong, Y;Ma, X;Miao, R;Balasubramanian, A;Puthenveetil, R;Banerjee, A;Luo, HR;Kagan, JC;Oh, SF;Robinson, CV;Lieberman, J;Wu, H;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Gasdermin D (GSDMD) is the common effector for cytokine secretion and pyroptosis downstream of infla....
Immunogenicity and efficacy studies of Endo H in vivo deglycosylated Protective Antigen from Bacillus anthracis as a vaccine candidate against anthrax
Research Square
Mamedov, T;Gun, N;Gulec, B;Khozeini, H;Ungor, R;Yuksel, D;Arslan, A;Dilik, Z;Deniz, D;Goven, N;Mammadova, G;Hasanova, G;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Protective antigen (PA) of B. anthracis is a key component of the anthrax toxin and have been demons....
Species-specific NLRP3 regulation and its role in CNS autoinflammatory diseases
Cell Reports
Koller, B;Nguyen, M;Snouwaert, J;Gabel, C;Ting, J;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
The NLRP3 inflammasome is essential for caspase-1 activation and the release of interleukin (IL)-1?,....
Early Circulating Edema Factor in Inhalational Anthrax Infection: Does It Matter?
Microorganisms
Tessier, E;Cheutin, L;Garnier, A;Vigne, C;Tournier, JN;Rougeaux, C;
Product: Anti-Edema Factor from B. anthracis (Goat)
Anthrax toxins are critical virulence factors of Bacillus anthracis and Bacillus cereus strains that....
Effect of human complement proteins on the activity of binary bacterial toxins of Clostridium botulinum and Bacillus anthracis
Thesis
Wohlfart, J;
Product: Anthrax Lethal Factor (LF), Recombinant from B. anthracis
C2 toxin from Clostridium botulinum and lethal toxin from Bacillus anthracis are both composed of an....
Discovery of Clinical Candidate NT-0796, a Brain-Penetrant and Highly Potent NLRP3 Inflammasome Inhibitor for Neuroinflammatory Disorders
Journal Of Medicinal Chemistry
Harrison, D;Billinton, A;Bock, MG;Doedens, JR;Gabel, CA;Holloway, MK;Porter, RA;Reader, V;Scanlon, J;Schooley, K;Watt, AP;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
The NLRP3 inflammasome is a component of the innate immune system involved in the production of proi....
Anthrax lethal toxin and tumor necrosis factor-α synergize on intestinal epithelia to induce mouse death
Protein & Cell
Gao, X;Teng, T;Liu, Y;Ai, T;Zhao, R;Fu, Y;Zhang, P;Han, J;Zhang, Y;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Bacillus anthracis (B. anthracis) lethal toxin (LT) is a determinant of lethal anthrax. Its function....
Muscimol inhibits plasma membrane rupture and ninjurin-1 oligomerization during pyroptosis
Communications Biology
den Hartigh, AB;Loomis, WP;Anderson, MJ;Frølund, B;Fink, SL;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Pyroptosis is a cell death process that causes inflammation and contributes to numerous diseases. Py....
Ros-Dependent Palmitoylation Activates Pore Formation by Cleaved and Intact Gsdmd
Cell
Du, G;Healy, L;David, L;Walker, C;El-Baba, T;Lutomski, C;Goh, B;Pi, X;Fontana, P;Dong, Y;Ma, X;Miao, R;Devant, P;Puthenveetil, R;Banerjee, A;Kagan, J;Oh, S;Robinson, C;Lieberman, J;Wu, H;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Here we report that S-palmitoylation at Cys191 of GSDMD enables pore formation by both cleaved GSDMD....
Development of a New Cell-Based AP-1 Gene Reporter Potency Assay for Anti-Anthrax Toxin Therapeutics
Toxins
Ouyang, W;Xie, T;Fang, H;Frucht, D;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Anthrax toxin is a critical virulence factor of Bacillus anthracis. The toxin comprises protective a....
Inhalable vaccine of bacterial culture supernatant extract mediates protection against fatal pulmonary anthrax
Emerging Microbes & Infections
Zhai, LN;Zhao, Y;Song, XL;Qin, TT;Zhang, ZJ;Wang, JZ;Sui, CY;Zhang, LL;Lv, M;Hu, LF;Zhou, DS;Fang, TY;Yang, WH;Wang, YC;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Pulmonary anthrax is the most fatal clinical form of anthrax and currently available injectable vacc....
Research on Detection of Ultra-Low Concentration Anthrax Protective Antigen Using Graphene Field-Effect Transistor Biosensor
Sensors
Liang, T;Chen, J;Yan, R;Jiang, H;Li, H;
Product: Anti-Protective Antigen from B. anthracis (Goat)
Protective antigen (PA) is an important biomarker for the early diagnosis of anthrax, and the accura....
Chloroquine-analogues block anthrax protective antigen channels in steady-state and kinetic studies
Toxicology
Beitzinger, C;Kronhardt, A;Benz, R;
Product: Anthrax Protective Antigen, Activated (PA 63) from B. anthracis
The tripartite anthrax toxin from Bacillus anthracis represents the prototype of A-B type of toxins,....
The designation, synthesis, and affinity determination of affinity peptide for anthrax protective antigen
Chemical Biology & Drug Design
Liang, T;Chen, J;Rui, Y;Hexi, L;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Detection of anthrax protective antigen is an effective way to diagnose anthracnose, and it plays an....
Immunogenicity and Protective Efficacy of Recombinant Protective Antigen Anthrax Vaccine (GC1109) in A/J Mice Model
Vaccine
Kim, GL;Pyo, SW;Yi, H;Kim, SH;Shin, H;Yu, MA;Hwang, YR;Choi, SY;Jeon, JH;Jo, SK;Rhie, GE;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
A recombinant protective antigen anthrax vaccine (GC1109) is being developed as a new-generation vac....
CARD-only proteins regulate invivo inflammasome responses and ameliorate gout
Cell Reports
Devi, S;Indramohan, M;Jäger, E;Carriere, J;Chu, LH;de Almeida, L;Greaves, DR;Stehlik, C;Dorfleutner, A;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Inflammatory responses are crucial for controlling infections and initiating tissue repair. However,....
Beyond the spore, the exosporium sugar anthrose impacts vegetative Bacillus anthracis gene regulation in cis and trans
Scientific Reports
Norris, MH;Bluhm, AP;Metrailer, MC;Jiranantasak, T;Kirpich, A;Hadfield, T;Ponciano, JM;Blackburn, JK;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
The Bacillus anthracis exosporium nap is the outermost portion of spore that interacts with the envi....
Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic activity
Immunity
Wu, X;Yang, ZH;Wu, J;Han, J;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
NOD-like receptors (NLRs) are pattern recognition receptors for diverse innate immune responses. Sel....
Rapidin vitroactivity of telavancin againstBacillus anthracisandin vivoprotection against inhalation anthrax infection in the rabbit model
Biorxiv
Lawrence, W;Peel, J;Slayden, R;Peterson, J;Baze, W;Hensel, M;Whorton, E;Beasley, D;Cummings, J;Macias-Perez, I;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Anthrax, caused by the bacterium Bacillus anthracis, is a zoonotic disease that manifests in various....
Gasdermin D pore-forming activity is redox-sensitive
Cell Reports
Devant, P;BorÂi?, E;Ngwa, EM;Xiao, H;Chouchani, ET;Thiagarajah, JR;Hafner-Bratkovi?, I;Evavold, CL;Kagan, JC;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Reactive oxygen species (ROS) regulate the activities of inflammasomes, which are innate immune sign....
Product: Anthrax Lethal Factor (LF), Recombinant from B. anthracis
The intestine is a non-sterile organ that must maintain its epithelial barrier to prevent microbial ....
Comprehensive characterization of toxins during progression of inhalation anthrax in a non-human primate model
Plos Pathogens
Boyer, AE;Gallegos-Candela, M;Lins, RC;Solano, MI;Woolfitt, AR;Lee, JS;Sanford, DC;Knostman, KAB;Quinn, CP;Hoffmaster, AR;Pirkle, JL;Barr, JR;
Product: Anthrax Lethal Factor (LF), Recombinant from B. anthracis
Inhalation anthrax has three clinical stages: early-prodromal, intermediate-progressive, and late-fu....
Host Cell Transcriptional Tuning with CRISPR/dCas9 to Mitigate the Effects of Toxin Exposure
ACS Synthetic Biology
Metzger, D;Miller, K;Lyon, W;Migliozzi, R;Pangburn, HA;Saldanha, R;
Product: Anthrax Lethal Factor (LF), Recombinant from B. anthracis
Anthrax infection is caused byBacillus anthracis, a bacterium that once established within the host ....
Transcriptional licensing is required for Pyrin inflammasome activation in human macrophages and bypassed by mutations causing familial Mediterranean fever
Plos Biology
Mangan, MSJ;Gorki, F;Krause, K;Heinz, A;Pankow, A;Ebert, T;Jahn, D;Hiller, K;Hornung, V;Maurer, M;Schmidt, FI;Gerhard, R;Latz, E;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Pyrin is a cytosolic immune sensor that nucleates an inflammasome in response to inhibition of RhoA ....
Lack of evidence for a role of anthrax toxin receptors as surface receptors for collagen VI and for its cleaved-off C5 domain/endotrophin
iScience
Przyklenk, M;Heumüller, SE;Freiburg, C;Lütke, S;Sengle, G;Koch, M;Paulsson, M;Schiavinato, A;Wagener, R;
Product: Anti-Protective Antigen from B. anthracis (Goat)
The microfibril-forming collagen VI is proteolytically cleaved and it was proposed that the released....
Label-free high-precise nanopore detection of endopeptidase activity of anthrax lethal factor regulated by diverse conditions
Biosensors & Bioelectronics
Li, M;Chen, S;Wang, Y;Zhang, S;Song, D;Tian, R;Geng, J;Wang, L;
Product: Anthrax Lethal Factor (LF), Recombinant from B. anthracis
Endopeptidase activity of anthrax lethal factor (aLF) prevents the destroy of anthracis spore intrac....
ER-Golgi-localized proteins TMED2 and TMED10 control the formation of plasma membrane lipid nanodomains
Developmental Cell
Anwar, MU;Sergeeva, OA;Abrami, L;Mesquita, FS;Lukonin, I;Amen, T;Chuat, A;Capolupo, L;Liberali, P;D'Angelo, G;van der Goot, FG;
Product: Anti-Protective Antigen from B. anthracis (Goat)
To promote infections, pathogens exploit host cell machineries such as structural elements of the pl....
Label-Free Nanopore Observation on Regulation of Endopeptidase Activity of Anthrax Lethal Factor
SSRN Electronic Journal
Li, M;Wang, Y;Zhang, S;Song, D;Tian, R;Wang, L;
Product: Anthrax Lethal Factor (LF-A), Recombinant from B. anthracis Native Sequence
Endopeptidase activity of anthrax lethal factor (aLF) prevents the destroy of anthracis spore intrac....
Group 3 innate lymphocytes (ILC3s) upregulate IL-22 in response to elevated intracellular cAMP levels
Cytokine
Sah, P;Derouen, JT;Alexander, JL;Zenewicz, LA;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Group 3 innate lymphocytes (ILC3s) are important immune cells within mucosal tissues and protect aga....
Antibodies against Anthrax Toxins: A Long Way from Benchlab to the Bedside
Toxins
Avril, A;Tournier, J;Paucod, J;Fournes, B;Thullier, P;Pelat, T;
Product: Anthrax Lethal Factor (LF), Recombinant from B. anthracis
Anthrax is an acute disease caused by the bacterium Bacillus anthracis, and is a potential biowarfar....
Immunological Evidence of Variation in Exposure and Immune Response to Bacillus anthracis in Herbivores of Kruger and Etosha National Parks
Frontiers In Immunology
Ochai, SO;Crafford, JE;Hassim, A;Byaruhanga, C;Huang, YH;Hartmann, A;Dekker, EH;van Schalkwyk, OL;Kamath, PL;Turner, WC;van Heerden, H;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Exposure and immunity to generalist pathogens differ among host species and vary across spatial scal....
Hydrogen-Deuterium Exchange Mass Spectrometry Reveals a Novel Binding Region of a Neutralizing Fully Human Monoclonal Antibody to Anthrax Protective Antigen
Toxins
Fang, M;Wang, Z;Norris, K;James, JA;Wu, S;Smith, K;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Anthrax vaccine adsorbed (AVA) containing protective antigen (PA) is the only FDA-approved anthrax v....
Differential gene regulation and study of the secretome of Bacillus anthracis and Bacillus cereus biovar anthracis
Thesis
Gummelt, C;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Seit den Untersuchungen von Robert Koch ist Bacillus anthracis als der Erreger von Milzbrand bekannt....
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Programmed cell death is a normal process in living organisms that removes damaged or infected cells....
Caspase-1 and Gasdermin D afford the optimal targets with distinct switching strategies in NLRP1b inflammasome-induced cell death
Research SPJ - Science Partner Journals
Qu, ZL;Qi, H;Yao, C;Shuai, J;
Product: Anthrax Lethal Factor (LF), Recombinant from B. anthracis
Inflammasomes are essential complexes of innate immune system, which form the first line of host def....
Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2+ DRG sensory neurons
Nature Neuroscience
Yang, NJ;Isensee, J;Neel, DV;Quadros, AU;Zhang, HB;Lauzadis, J;Liu, SM;Shiers, S;Belu, A;Palan, S;Marlin, S;Maignel, J;Kennedy-Curran, A;Tong, VS;Moayeri, M;Röderer, P;Nitzsche, A;Lu, M;Pentelute, BL;Brüstle, O;Tripathi, V;Foster, KA;Price, TJ;Collier, RJ;Leppla, SH;Puopolo, M;Bean, BP;Cunha, TM;Hucho, T;Chiu, IM;
Product: Anthrax Lethal Factor (LF-A), Recombinant from B. anthracis Native Sequence
Bacterial products can act on neurons to alter signaling and function. In the present study, we foun....
Solution Structures of Bacillus anthracis Protective Antigen Proteins Using Small Angle Neutron Scattering and Protective Antigen 63 Ion Channel Formation Kinetics
Toxins
Michelman-Ribeiro, A;Rubinson, KA;Silin, V;Kasianowicz, JJ;
Product: Anthrax Protective Antigen, Activated (PA 63) from B. anthracis
We are studying the structures of bacterial toxins that form ion channels and enable macromolecule t....
Multiplexed, High-Sensitivity Measurements of Antibody Affinity Using Interferometric Reflectance Imaging Sensor
Biosensors
Marn, AM;Needham, J;Chiodi, E;Ãnlü, MS;
Product: Anthrax Protective Antigen, Activated (PA 63) from B. anthracis
Anthrax lethal factor (LF) is one of the enzymatic components of the anthrax toxin responsible for t....
Adaptive Membrane Fluidity Modulation: A Feedback Regulated Homeostatic System and Target for Pharmacological Intervention
In Vivo (Athens, Greece)
Izbicka, E;Streeper, RT;Louden, C;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Alterations of plasma membrane fluidity are characteristic of many diseases but the intentional modu....
NLRC4 inflammasome-dependent cell death occurs by a complementary series of three death pathways and determines lethality in mice
Science Advances
Zhang, P;Liu, Y;Hu, L;Huang, K;Hong, M;Wang, Y;Fan, X;Ulevitch, RJ;Han, J;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Inflammasome is an innate immune defense mechanism, but its overactivation can lead to host death. H....
Liposome-based nanocarriers loaded with anthrax lethal factor and armed with anti-CD19 VHH for effectively inhibiting MAPK pathway in B cells
International Immunopharmacology
Banihashemi, SR;Rahbarizadeh, F;Zavaran Hosseini, A;Ahmadvand, D;Khoshtinat Nikkhoi, S;
Product: Anthrax Lethal Factor (LF-A), Recombinant from B. anthracis Native Sequence
One of the vital signaling pathways in cancer development and metastasis is mitogen-activated protei....
Inhibition of elastase enhances the adjuvanticity of alum and promotes anti-SARS-CoV-2 systemic and mucosal immunity
Proceedings Of The National Academy Of Sciences Of The United States Of America
Kim, E;Attia, Z;Woodfint, RM;Zeng, C;Kim, SH;Steiner, HE;Shukla, RK;Liyanage, NPM;Ghimire, S;Li, J;Renukaradhya, GJ;Satoskar, AR;Amer, AO;Liu, SL;Cormet-Boyaka, E;Boyaka, PN;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Alum, used as an adjuvant in injected vaccines, promotes T helper 2 (Th2) and serum antibody (Ab) re....
Inflammasome-induced extracellular vesicles harbour distinct RNA signatures and alter bystander macrophage responses
Journal of Extracellular Vesicles
Budden, CF;Gearing, LJ;Kaiser, R;Standke, L;Hertzog, PJ;Latz, E;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Infectious organisms and damage of cells can activate inflammasomes, which mediate tissue inflammati....
Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway
Cell
Evavold, CL;Hafner-Bratkovi?, I;Devant, P;D'Andrea, JM;Ngwa, EM;BorÂi?, E;Doench, JG;LaFleur, MW;Sharpe, AH;Thiagarajah, JR;Kagan, JC;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
The process of pyroptosis is mediated by inflammasomes and a downstream effector known as gasdermin ....
In Vivo Activity of Repurposed Amodiaquine as a Host-Targeting Therapy for the Treatment of Anthrax
ACS Infectious Diseases
Martchenko Shilman, M;Bartolo, G;Alameh, S;Peterson, JW;Lawrence, WS;Peel, JE;Sivasubramani, SK;Beasley, DWC;Cote, CK;Demons, ST;Halasahoris, SA;Miller, LL;Klimko, CP;Shoe, JL;Fetterer, DP;McComb, R;Ho, CC;Bradley, KA;Hartmann, S;Cheng, LW;Chugunova, M;Kao, CY;Tran, JK;Derbedrossian, A;Zilbermintz, L;Amali-Adekwu, E;Levitin, A;West, J;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Anthrax is caused by Bacillus anthracis and can result in nearly 100% mortality due in part to anthr....
Label-free and Rapid Detection of Anthrax Protective Antigen by Surface-enhanced Raman Scattering on Au Nanorods
IEEE Sensors Journal
Li, B;Wang, T;Bai, W;Su, Q;Wu, X;Dong, P;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Aiming at the requirement of ultra-sensitive on-site rapid detection of anthrax protective antigens ....
Hemolysis-associated phosphatidylserine exposure promotes polyclonal plasmablast differentiation
The Journal Of Experimental Medicine
Vijay, R;Guthmiller, JJ;Sturtz, AJ;Crooks, S;Johnson, JT;Li, L;Lan, LY;Pope, RL;Chen, Y;Rogers, KJ;Dutta, N;Toombs, JE;Wilson, ME;Wilson, PC;Maury, W;Brekken, RA;Butler, NS;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Antimalarial antibody responses are essential for mediating the clearance of Plasmodium parasite-inf....
Insufficient Anthrax Lethal Toxin Neutralization Is Associated with Antibody Subclass and Domain Specificity in the Plasma of Anthrax-Vaccinated Individuals
Microorganisms
Smith, K;Garman, L;Norris, K;Muther, J;Duke, A;Engler, RJM;Nelson, MR;Collins, LC;Spooner, C;Guthridge, C;James, JA;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Anthrax vaccine adsorbed (AVA) is a significant line of defense against bioterrorist attack from Bac....
Hydrophobic Gating and 1/f Noise of the Anthrax Toxin Channel
The Journal Of Physical Chemistry
Yamini, G;Kanchi, S;Kalu, N;Momben Abolfath, S;Leppla, SH;Ayappa, KG;Maiti, PK;Nestorovich, EM;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
“Pink” or 1/f noise is a natural phenomenon omnipresent in physics, economics, astrophysics, biology....
HDAC8 Activates AKT through Upregulating PLCB1 and Suppressing DESC1 Expression in MEK1/2 Inhibition-Resistant Cells
Cells
Ha, SD;Lewin, N;Li, SSC;Kim, SO;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Inhibition of the RAF-MEK1/2-ERK signaling pathway is an ideal strategy for treating cancers with NR....
Proteomics reveals distinct mechanisms regulating the release of cytokines and alarmins during pyroptosis
Cell Reports
Phulphagar, K;Kühn, LI;Ebner, S;Frauenstein, A;Swietlik, JJ;Rieckmann, J;Meissner, F;
Product: Anthrax Lethal Factor (LF), Recombinant from B. anthracis
A major pathway for proinflammatory protein release by macrophages is inflammasome-mediated pyroptot....
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Vaccines are biological preparations that are used to educate the immune system and make it develop ....
Simultaneous vaccination and therapy against anthrax: a dominant-negative inhibitor of the protective antigen of B. anthracis is. at the same time a potent and safe antigen for a vaccine
Dankonoy.Com
Aulinger, BA;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
As already described above, the toxin effect of _B. anthracis_ of crucial importance for the full pa....
Product: Anthrax Lethal Factor (LF), Recombinant from B. anthracis
This article presents assays that allow induction and measurement of activation of different inflamm....
Human NLRP1 is a sensor for double-stranded RNA
Science
Bauernfried, S;Scherr, MJ;Pichlmair, A;Duderstadt, KE;Hornung, V;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Inflammasomes function as intracellular sensors of pathogen infection or cellular perturbation and t....
Immunogenicity and Protective Efficacy of a Non-Living Anthrax Vaccine versus a Live Spore Vaccine with Simultaneous Penicillin-G Treatment in Cattle
Vaccines
Jauro, S;Ndumnego, OC;Ellis, C;Buys, A;Beyer, W;Heerden, HV;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
: Sterne live spore vaccine (SLSV) is the current veterinary anthrax vaccine of choice. Unlike the n....
A comprehensive guide to studying inflammasome activation and cell death
Nature Protocols
Tweedell, RE;Malireddi, RKS;Kanneganti, TD;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Inflammasomes are multimeric heterogeneous mega-Dalton protein complexes that play key roles in the ....
A serological survey of Bacillus anthracis reveals widespread exposure to the pathogen in free-range and captive lions in Zimbabwe
Transboundary and Emerging Diseases
Mukarati, NL;Ndumnego, OC;Ochai, SO;Jauro, S;Loveridge, A;van Heerden, H;Matope, G;Caron, A;Hanyire, TG;de Garine-Wichatitsky, M;Pfukenyi, DM;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Numerous unknown factors influence anthrax epidemiology in multi‐host systems, especially at wildlif....
HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation
Science
Magupalli, VG;Negro, R;Tian, Y;Hauenstein, AV;Di Caprio, G;Skillern, W;Deng, Q;Orning, P;Alam, HB;Maliga, Z;Sharif, H;Hu, JJ;Evavold, CL;Kagan, JC;Schmidt, FI;Fitzgerald, KA;Kirchhausen, T;Li, Y;Wu, H;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Inflammasomes are supramolecular complexes that play key roles in immune surveillance. This is accom....
Anthrax toxin component, Protective Antigen, protects insects from bacterial infections
PLoS Pathogens
Alameh, S;Bartolo, G;O'Brien, S;Henderson, EA;Gonzalez, LO;Hartmann, S;Klimko, CP;Shoe, JL;Cote, CK;Grill, LK;Levitin, A;Martchenko Shilman, M;
Product: Anthrax Edema Factor (EF), Recombinant from B. anthracis
Anthrax is a major zoonotic disease of wildlife, and in places like West Africa, it can be caused by....
Anthrax Edema and Lethal Toxins Differentially Target Human Lung and Blood Phagocytes
Toxins
Patel, VI;Booth, JL;Dozmorov, M;Brown, BR;Metcalf, JP;
Product: Anthrax Protective Antigen, Activated (PA 63) from B. anthracis
Bacillus anthracis, the causative agent of inhalation anthrax, is a serious concern as a bioterroris....
Assessment of vaccination strategies against Bacillus cereus biovar anthracis in wild great apes
Thesis
Lang, A;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Besides poaching and habitat loss, infectious diseases can also contribute significantly towards the....
Protective antibody response following oral vaccination with microencapsulated Bacillus Anthracis Sterne strain 34F2 spores
npj/Vaccines
Benn Felix, J;Chaki, SP;Xu, Y;Ficht, TA;Rice-Ficht, AC;Cook, WE;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
An oral vaccine against anthrax (Bacillus anthracis) is urgently needed to prevent annual anthrax ou....
Immunogenicity of Non-Living Anthrax Vaccine Candidates in Cattle and Protective Efficacy of Immune Sera in A/J Mouse Model Compared to the Sterne Live Spore Vaccine
Pathogens
Jauro, S;Ndumnego, OC;Ellis, C;Buys, A;Beyer, W;Heerden, HV;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
The Sterne live spore vaccine (SLSV, Bacillus anthracis strain 34F2) is the veterinary vaccine of ch....
BPTES inhibits anthrax lethal toxin-induced inflammatory response
International Immunopharmacology
Wang, J;Yang, D;Shen, X;Wang, J;Liu, X;Lin, J;Zhong, J;Zhao, Y;Qi, Z;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Bacillus anthracis is a lethal agent of anthrax disease and the toxins are required in anthrax patho....
Ligand Binding to the Collagen VI Receptor Triggers a Talin-to-RhoA Switch that Regulates Receptor Endocytosis
Developmental Cell
Brgi, J;Abrami, L;Castanon, I;Abriata, LA;Kunz, B;Yan, SE;Lera, M;Unger, S;Superti-Furga, A;Peraro, MD;Gaitan, MG;van der Goot, FG;
Product: Anti-Protective Antigen from B. anthracis (Goat)
Capillary morphogenesis gene 2 (CMG2/ANTXR2) is a cell surface receptor for both collagen VI and ant....
Platelets Fuel the Inflammasome Activation of Innate Immune Cells
Cell Reports
Rolfes, V;Ribeiro, LS;Hawwari, I;Bttcher, L;Rosero, N;Maasewerd, S;Santos, MLS;Prchnicki, T;Silva, CMS;Wanderley, CWS;Rothe, M;Schmidt, SV;Stunden, HJ;Bertheloot, D;Rivas, MN;Fontes, CJ;Carvalho, LH;Cunha, FQ;Latz, E;Arditi, M;Franklin, BS;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
The inflammasomes control the bioactivity of pro-inflammatory cytokines of the interleukin (IL)-1 fa....
Toxin-neutralizing antibodies elicited by naturally acquired cutaneous anthrax are elevated following severe disease and appear to target conformational epitopes
Plos One
Dumas, EK;Demiraslan, H;Ingram, RJ;Sparks, RM;Muns, E;Zamora, A;Larabee, J;Garman, L;Ballard, JD;Boons, GJ;James, JA;Kayabas, U;Doganay, M;Farris, AD;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Understanding immune responses to native antigens in response to natural infections can lead to impr....
An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages
SSRN Electronic Journal
de Vasconcelos, N;Van Opdenbosch, N;Van Gorp, H;Martn-Prez, R;Zecchin, A;Vandenabeele, P;Lamkanfi, M;
Product: Anthrax Lethal Factor (LF), Recombinant from B. anthracis
Pyroptosis has emerged as a powerful defense mechanism of the host against microbial pathogens. It a....
Product: Anthrax Lethal Factor (LF-A), Recombinant from B. anthracis Native Sequence
Bacillus anthracis is regarded as a major biological warfare threat. Inhalation of Bacillus anthraci....
The Vibrio cholerae MARTX toxin silences the inflammatory response to cytoskeletal damage before inducing actin cytoskeleton collapse
Science Signaling
Woida, PJ;Satchell, KJF;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Multifunctional autoprocessing repeats-in-toxin (MARTX) toxins are pore-forming bacterial toxins tha....
Cryo-EM structure of the fully-loaded asymmetric anthrax lethal toxin in its heptameric pre-pore state
Biorxiv
Antoni, C;Quentin, D;Lang, AE;Aktories, K;
Product: Anthrax Lethal Factor (LF-A), Recombinant from B. anthracis Native Sequence
Anthrax toxin is the major virulence factor secreted by Bacillus anthracis, causing high mortality i....
Anthrax Toxin as a Molecular Platform to Target Nociceptive Neurons and Modulate Pain
Biorxiv
Yang, NJ;Isensee, J;Neel, D;Liu, SM;Zhang, HXB;
Product: Anthrax Lethal Factor (LF-A), Recombinant from B. anthracis Native Sequence
Bacterial toxins are able to act on neurons to modulate signaling and function. Here, we find that n....
Eicosapentaenoic acid prevents inflammation induced by acute cerebral infarction through inhibition of NLRP3 inflammasome activation
Life Sciences
Mo, Z;Tang, C;Li, H;Lei, J;Zhu, L;Kou, L;Li, H;Luo, S;Li, C;Chen, W;Zhang, L;
Product: Anthrax Lethal Factor (LF), Recombinant from B. anthracis
Acute cerebral infarction (ACI) is the most common type of acute cerebrovascular diseases resulting ....
Influence of the phosphoenolpyruvate:carbohydrate phosphotransferase system on toxin gene expression and virulence in Bacillus anthracis
Molecular Microbiology
Bier, N;Hammerstrom, TG;Koehler, TM;
Product: Anti-Edema Factor from B. anthracis (Goat)
AtxA, the master virulence gene regulator of Bacillus anthracis, is a PRD-Containing Virulence Regul....
Very early blood diffusion of the active lethal and edema factors of Bacillus anthracis after intranasal infection
The Journal Of Infectious Diseases
Rougeaux, C;Becher, F;Goossens, PL;Tournier, JN;
Product: Anthrax Lethal Factor (LF), Recombinant from B. anthracis
Lethal and edema toxins are critical virulence factors of Bacillus anthracis. Few data are available....
The Vibrio cholerae MARTX toxin simultaneously induces actin collapse while silencing the inflammatory response to cytoskeletal damage
Biorxiv
Woida, PJ;Satchell, KJF;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Multifunctional autoprocessing repeats-in-toxin (MARTX) toxins are pore-forming toxins that transloc....
DPP8/9 inhibitors are universal activators of functional NLRP1 alleles
Cell Death & Disease
Gai, K;Okondo, MC;Rao, SD;Chui, AJ;Ball, DP;Johnson, DC;Bachovchin, DA;
Product: Anthrax Lethal Factor (LF), Recombinant from B. anthracis
Intracellular pathogenic structures or activities stimulate the formation of inflammasomes, which re....
Alternative splicing regulates stochastic NLRP3 activity
Nature Communications
Hoss, F;Mueller, JL;Rojas Ringeling, F;Rodriguez-Alcazar, JF;Brinkschulte, R;Seifert, G;Stahl, R;Broderick, L;Putnam, CD;Kolodner, RD;Canzar, S;Geyer, M;Hoffman, HM;Latz, E;
Product: Anthrax Lethal Factor (LF), Recombinant from B. anthracis
Leucine-rich repeat (LRR) domains are evolutionarily conserved in proteins that function in developm....
Distinct Spatiotemporal Distribution of Bacterial Toxin-Produced Cellular cAMP Differentially Inhibits Opsonophagocytic Signaling
Toxins
Hasan, S;Rahman, WU;Sebo, P;Osicka, R;
Product: Anthrax Edema Factor (EF), Recombinant from B. anthracis
Myeloid phagocytes have evolved to rapidly recognize invading pathogens and clear them through opson....
Rapid Discovery and Characterization of Synthetic Neutralizing Antibodies against Anthrax Edema Toxin
Biochemistry
Farcasanu, M;Wang, AG;Uchaski, T;Bailey, LJ;Yue, J;Chen, Z;Wu, X;Kossiakoff, A;Tang, WJ;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Anthrax, a lethal, weaponizable disease caused by Bacillus anthracis, acts through exotoxins that ar....
Product: Anthrax Lethal Factor (LF-A), Recombinant from B. anthracis Native Sequence
Bacillus anthracis is regarded as a major biological warfare threat. The inhalation form of Bacillus....
Endocytic recycling and vesicular transport systems mediate transcytosis of Leptospira interrogans across cell monolayer
Elife
Li, Y;Li, KX;Hu, WL;Ojcius, DM;Fang, JQ;Li, SJ;Lin, X;Yan, J;
Product: Anthrax Edema Factor (EF), Recombinant from B. anthracis
Many bacterial pathogens can cause septicemia and spread from the bloodstream into internal organs. ....
Diverse small molecules prevent macrophage lysis during pyroptosis
Cell Death & Disease
Loomis, WP;den Hartigh, AB;Cookson, BT;Fink, SL;
Product: Anthrax Lethal Factor (LF), Recombinant from B. anthracis
Pyroptosis is a programmed process of proinflammatory cell death mediated by caspase-1-related prote....
Zeptomole per milliliter detection and quantification of edema factor in plasma by LC-MS/MS yields insights into toxemia and the progression of inhalation anthrax
Analytical And Bioanalytical Chemistry
Lins, RC;Boyer, AE;Kuklenyik, Z;Woolfitt, AR;Goldstein, J;Hoffmaster, AR;Gallegos-Candela, M;Leysath, CE;Chen, Z;Brumlow, JO;Quinn, CP;Bagarozzi, DA;Leppla, SH;Barr, JR;
Product: Anthrax Protective Antigen, Activated (PA 63) from B. anthracis
Inhalation of Bacillus anthracis spores can cause a rapidly progressing fatal infection. B. anthraci....
Accurate and selective quantification of anthrax protective antigen in plasma by immunocapture and isotope dilution mass spectrometry
The Analyst
Solano, MI;Woolfitt, AR;Boyer, AE;Lins, RC;Isbell, K;Gallegos-Candela, M;Moura, H;Pierce, CL;Barr, JR;
Product: Anthrax Lethal Factor (LF), Recombinant from B. anthracis
Anthrax protective antigen (83 kDa, PA83) is an essential component of two major binary toxins produ....
Bacillus anthracis Edema Toxin Inhibits Efferocytosis in Human Macrophages and Alters Efferocytic Receptor Signaling
International Journal Of Molecular Sciences
Pan, Z;Dumas, EK;Lawrence, C;Pate, L;Longobardi, S;Wang, X;James, JA;Kovats, S;Farris, AD;
Product: Anthrax Edema Factor (EF), Recombinant from B. anthracis
The Bacillus anthracis Edema Toxin (ET), composed of a Protective Antigen (PA) and the Edema Factor ....
Formulation of aluminum hydroxide adjuvant with TLR agonists poly(I:C) and CpG enhances the magnitude and avidity of the humoral immune response
Vaccine
Lu, F;Mosley, YC;Carmichael, B;Brown, DD;HogenEsch, H;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Subunit vaccines generally require adjuvants to achieve optimal immune responses. Toll-like receptor....
ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination
The EMBO Journal
Ren, G;Zhang, X;Xiao, Y;Zhang, W;Wang, Y;Ma, W;Wang, X;Song, P;Lai, L;Chen, H;Zhan, Y;Zhang, J;Yu, M;Ge, C;Li, C;Yin, R;Yang, X;
Product: Anthrax Lethal Factor (LF-A), Recombinant from B. anthracis Native Sequence
Deubiquitination of NLRP3 has been suggested to contribute to inflammasome activation, but the roles....
Single dose of DPX-rPA, an enhanced-delivery anthrax vaccine formulation, protects against a lethal Bacillusanthracis spore inhalation challenge
NPJ Vaccines
Weir, GM;MacDonald, LD;Rajagopalan, R;Sivko, GS;Valderas, MW;Rayner, J;Berger, BJ;Sammatur, L;Stanford, MM;
Product: Anthrax Protective Antigen (PA), Recombinant from B. anthracis
Anthrax is a serious biological threat caused by pulmonary exposure to aerosolized spores of Bacillu....
A therapeutic human antibody against the domain 4 of the Bacillus anthracis protective antigen shows protective efficacy in a mouse model
Biochemical And Biophysical Research Communications
Ahn, BE;Bae, HW;Lee, HR;Woo, SJ;Park, OK;Jeon, JH;Park, J;Rhie, GE;
Product: Anthrax Lethal Factor (LF), Recombinant from B. anthracis
Since Bacillus anthracis is a high-risk pathogen and a potential tool for bioterrorism, numerous the....
Optimization of a FRET Assay for Evaluating the Biological Activity of Anthrax Lethal Factor Inhibitors
Pointloma.Whdl.Org
Veenbaas, SD;Rouffet, MJ;
Product: MAPKKide® Peptide Substrate (o-Abz/Dnp) for Anthrax Lethal Factor
Anthrax is a deadly infection caused by spores of the gram-positive bacterium Bacillus anthracis. Pa....
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