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Tolerogenic dendritic cell-mediated regulatory T cell differentiation by Chinese herbal formulation attenuates colitis progression
Journal Of Advanced Research
Huang, C;Lyu, C;Mok, HL;Xu, Y;Cheng, KW;Zhang, C;Hu, D;Zhu, L;Lin, C;Chen, X;Tan, HY;Bian, Z;
Product: Diphtheria Toxin CRM197, Mutant
Ulcerative colitis (UC) is a chronic inflammatory disease characterized by loss of immune tolerance ....
Methods employed in a 2021 population-based serosurvey in Somalia
Gates Open Research
Hossain, M;Ali, A;Clary, C;Cooley, G;Farid, M;Gerber, S;Hoff, N;Ibrahim, A;Mainou, B;Malik, D;Martin, H;Mdodo, R;Mengistu, K;Obsie, A;Reynolds, Z;Rhoda, D;Shube, M;Sinai, C;Trimner, M;Webeck, J;
Product: Diphtheria Toxoid, from Corynebacterium diphtheriae
This paper describes the design and methods of a serosurvey conducted in Somalia in 2021. The study ....
Heterologous Expression of Recombinant Proteins and Their Derivatives Used as Carriers for Conjugate Vaccines
Biochemistry (Moscow)
Khodak, YA;
Product: Diphtheria Toxin CRM197, Mutant
Carrier proteins that provide an effective and long-term immune response to weak antigens has become....
Tetanus and Diphtheria Seroprotection among Children Younger Than 15 Years in Nigeria, 2018: Who Are the Unprotected Children?
Vaccines
Tohme, RA;Scobie, HM;Okunromade, O;Olaleye, T;Shuaib, F;Jegede, T;Yahaya, R;Nnaemeka, N;Lawal, B;Egwuenu, A;Parameswaran, N;Cooley, G;An, Q;Coughlin, M;Okposen, BB;Adetifa, I;Bolu, O;Ihekweazu, C;
Product: Diphtheria Toxoid, from Corynebacterium diphtheriae
Serological surveys provide an objective biological measure of population immunity, and tetanus sero....
Apolipoprotein E derived from CD11c+ cells ameliorates atherosclerosis
iScience
Sauter, M;Sauter, R;Nording, H;Lin, C;Olbrich, M;Autenrieth, S;Gleissner, C;Thunemann, M;Otero, N;Lutgens, E;Aherrahrou, Z;Wolf, D;Zender, L;Meuth, S;Feil, R;Langer, H;
Product: Diphtheria Toxin CRM197, Mutant
Atherosclerosis is studied in models with dysfunctional lipid homeostasis—predominantly the ApoE−/− ....
Effect of Preexisting Immunity to Tetanus Toxoid on the Efficacy of Tetanus Toxoid-Conjugated Heroin Vaccine in Mice
Vaccines
Komla, E;Torres, OB;Jalah, R;Sulima, A;Beck, Z;Alving, CR;Jacobson, AE;Rice, KC;Matyas, GR;
Product: Diphtheria Toxoid, from Corynebacterium diphtheriae
Opioid use disorder (OUD) is a serious health problem that has dramatically increased over the last ....
Immunisation with the BCG and DTPw vaccines induces different programs of trained immunity in mice
Vaccine
Stevens, NE;van Wolfswinkel, M;Bao, W;Ryan, FJ;Brook, B;Amenyogbe, N;Marshall, HS;Lynn, MA;Kollmann, TR;Tumes, DJ;Lynn, DJ;
Product: Diphtheria Toxoid, from Corynebacterium diphtheriae
In addition to providing pathogen-specific immunity, vaccines can also confer nonspecific effects (N....
Validation of a diphtheria toxoid multiplex bead assay for serosurveys
Diagnostic Microbiology And Infectious Disease
Scobie, H;Khetsuriani, N;Efstratiou, A;Priest, J;
Product: Diphtheria Toxoid, from Corynebacterium diphtheriae
We validated a multiplex bead assay for diphtheria toxoid IgG antibodies against the Vero cell toxin....
Seroprevalence of chronic hepatitis B virus infection and immunity to measles, rubella, tetanus and diphtheria among schoolchildren aged 6-7years old in the Solomon Islands, 2016
Vaccine
Breakwell, L;Anga, J;Cooley, G;Ropiti, L;Gwyn, S;Wannemuehler, K;Woodring, J;Ogaoga, D;Martin, D;Patel, M;Tohme, RA;
Product: Diphtheria Toxoid, from Corynebacterium diphtheriae
The Western Pacific Region (WPR) established a goal to decrease chronic hepatitis B virus (HBV) infe....
Product: Diphtheria Toxin CRM197, Mutant
Vaccines are often less effective in very young children whose immune systems are immature. For the ....
Integrated Cross-Sectional Multiplex Serosurveillance of IgG Antibody Responses to Parasitic Diseases and Vaccines in Coastal Kenya
The American Journal Of Tropical Medicine And Hygiene
Njenga, SM;Kanyi, HM;Arnold, BF;Matendechero, SH;Onsongo, JK;Won, KY;Priest, JW;
Product: Diphtheria Toxoid, from Corynebacterium diphtheriae
Accurate and cost-effective identification of areas where co-endemic infections occur would enable p....
A kinetic ELISA to determine the immunoreactive fraction of monoclonal antibodies
Journal Of Immunological Methods
Moreno, I;Domnguez, M;Torao, A;
Product: Diphtheria Toxoid, from Corynebacterium diphtheriae
We developed a two-step ELISA to determine the immunoreactive fraction of monoclonal antibodies in c....
Multiplex serologic testing within a cross-sectional lymphatic filariasis sentinel site survey in coastal Kenya reveals community-level differences in IgG antibody responses to parasitic diseases and vaccines
Biorxiv
Njenga, SM;Kanyi, HM;Arnold, BF;Matendechero, HS;
Product: Diphtheria Toxoid, from Corynebacterium diphtheriae
Accurate, cost-effective measurement of the burden of co-endemic infections would enable public heal....
HIV, Cytomegalovirus, and Malaria Infections during Pregnancy Lead to Inflammation and Shifts in Memory B Cell Subsets in Kenyan Neonates
Journal Of Immunology
Yeo, KT;Embury, P;Anderson, T;Mungai, P;Malhotra, I;King, C;Kazura, J;Dent, A;
Product: Diphtheria Toxin CRM197, Mutant
Infections during pregnancy can expose the fetus to microbial Ags, leading to inflammation that affe....
Analytical Comparability Assessments of Five Recombinant CRM197Proteins from Different Manufacturers and Expression Systems
Journal Of Pharmaceutical Sciences
Hickey, JM;Toprani, VM;Kaur, K;Mishra, RPN;Goel, A;Oganesyan, N;Lees, A;Sitrin, R;Joshi, SB;Volkin, DB;
Product: Diphtheria Toxin CRM197, Mutant
CRM197, a single amino acid mutant of diphtheria toxoid, is a commonly used carrier protein in comme....
Defective anti-polysaccharide IgG vaccine responses in IgA deficient mice
Vaccine
Furuya, Y;Kirimanjeswara, GS;Roberts, S;Racine, R;Wilson-Welder, J;Sanfilippo, AM;Salmon, SL;Metzger, DW;
Product: Diphtheria Toxin CRM197, Mutant
We report that IgA(-/-) mice exhibit specific defects in IgG antibody responses to various polysacch....
Product: Diphtheria Toxin CRM197, Mutant
CD301b(+) dendritic cells suppress T follicular helper cells and antibody responses to protein antigens.
eLife
Kumamoto, Y;Hirai, T;Wong, PW;Kaplan, DH;Iwasaki, A;
Product: Diphtheria Toxin CRM197, Mutant
Strong antibody response is considered a hallmark of a successful vaccine. While dendritic cells (DC....
Efficacy, but not antibody titer or affinity, of a heroin hapten conjugate vaccine correlates with increasing hapten densities on tetanus toxoid, but not on CRM197 carriers
Bioconjugate Chemistry
Jalah, R;Torres, OB;Mayorov, AV;Li, F;Antoline, JF;Jacobson, AE;Rice, KC;Deschamps, JR;Beck, Z;Alving, CR;Matyas, GR;
Product: Diphtheria Toxin CRM197, Mutant
Vaccines against drugs of abuse have induced antibodies in animals that blocked the biological effec....
Vaccination of heifers with anaflatoxin improves the reduction of aflatoxin b1 carry over in milk of lactating dairy cows.
PLoS ONE
Giovati, L;Gallo, A;Masoero, F;Cerioli, C;Ciociola, T;Conti, S;Magliani, W;Polonelli, L;
Product: Diphtheria Toxin CRM197, Mutant
It was previously reported that injection of anaflatoxin B1 (AnAFB1) conjugated to keyhole limpet he....
Molecular signatures of antibody responses derived from a systems biology study of five human vaccines
Nature Immunology
Li, S;Rouphael, N;Duraisingham, S;Romero-Steiner, S;Presnell, S;Davis, C;Schmidt, DS;Johnson, SE;Milton, A;Rajam, G;Kasturi, S;Carlone, GM;Quinn, C;Chaussabel, D;Palucka, AK;Mulligan, MJ;Ahmed, R;Stephens, DS;Nakaya, HI;Pulendran, B;
Product: Diphtheria Toxoid, from Corynebacterium diphtheriae
Many vaccines induce protective immunity via antibodies. Systems biology approaches have been used t....
Macrophages directly mediate diabetic renal injury
American Journal Of Physiology - Renal Physiology
You, H;Gao, T;Cooper, TK;Brian Reeves, W;Awad, AS;
Product: Diphtheria Toxin CRM197, Mutant
Monocyte/macrophage recruitment correlates strongly with the progression of renal impairment in diab....
High-avidity IgG Autoantibodies against DFS70/LEDGF in Atopic Dermatitis
Journal Of Clinical & Cellular Immunology
Watanabe, K;Muro, Y;Sugiura, K;Akiyama, M;
Product: Diphtheria Toxoid, from Corynebacterium diphtheriae
Dense fine speckles 70 kDa protein (DFS70)/lens epitheliumderived growth factor (LEDGF) is a nuclear....
HB-EGF promotes intestinal restitution by affecting integrin-extracellular matrix interactions and intercellular adhesions
Growth Factors
Su, Y;Yang, J;Besner, GE;
Product: Diphtheria Toxin CRM197, Mutant
Restitution is a critical form of intestinal epithelial cell (IEC) healing. We have previously shown....
Development of novel O-polysaccharide based glycoconjugates for immunization against glanders.
Frontiers In Cellular And Infection Microbiology
Burtnick, MN;Heiss, C;Schuler, AM;Azadi, P;Brett, PJ;
Product: Diphtheria Toxin CRM197, Mutant
Burkholderia mallei the etiologic agent of glanders, causes severe disease in humans and animals and....
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