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Conditioning Electrical Nerve Stimulation Enhances Functional Rewiring in a Mouse Model of Nerve Transfer to Treat Chronic Spinal Cord Injury
Brain Sciences
Jara, J;Soliman, M;Bernstein, A;Grazia, P;Ferguson, A;Brown, J;Torres?Espín, A;Hollis, E;
Product: Anti-Cholera Toxin B Subunit (Goat)
Background/Objectives: Nerve transfer surgery is a state-of-the-art surgical approach to restore han....
The transcription factor combination MEF2 and KLF7 promotes axonal sprouting in the injured spinal cord with functional improvement and regeneration-associated gene expression
Molecular Neurodegeneration
Attwell, CL;Maldonado-Lasunción, I;Eggers, R;Bijleveld, BA;Ellenbroek, WM;Siersema, N;Razenberg, L;Lamme, D;Fagoe, ND;van Kesteren, RE;Smit, AB;Verhaagen, J;Mason, MRJ;
Product: Anti-Cholera Toxin B Subunit (Goat)
Axon regeneration after injury to the central nervous system (CNS) is limited by an inhibitory envir....
Widespread innervation of motoneurons by spinal V3 neurons globally amplifies locomotor output in mice
Cell Reports
Zhang, H;Deska-Gauthier, D;MacKay, CS;Hari, K;Lucas-Osma, AM;Borowska-Fielding, J;Letawsky, RL;Rancic, V;Akay, T;Fenrich, KK;Bennett, DJ;Zhang, Y;
Product: Anti-Cholera Toxin B Subunit (Goat)
While considerable progress has been made in understanding the neuronal circuits that underlie the p....
Conditioning electrical stimulation enhances functional rewiring in a mouse model of nerve transfer to treat chronic spinal cord injury
Biorxiv
Jara, J;Soliman, M;Bernstein, A;Grazia, P;Ferguson, A;Brown, J;Torres?Espín, A;Hollis, E;
Product: Anti-Cholera Toxin B Subunit (Goat)
Nerve transfer surgery is a state-of-the-art surgical approach to restore hand and arm function in i....
Encoding of cerebellar dentate neuron activity during visual attention in rhesus macaques
Elife
Flierman, NA;Koay, SA;van Hoogstraten, WS;Ruigrok, TJH;Roelfsema, P;Badura, A;De Zeeuw, CI;
Product: Anti-Cholera Toxin B Subunit (Goat)
The role of cerebellum in controlling eye movements is well established, but its contribution to mor....
Central amygdala-to-pre-Bötzinger complex neurotransmission is direct and inhibitory
The European Journal Of Neuroscience
Gu, J;Sugimura, YK;Kato, F;Del Negro, CA;
Product: Anti-Cholera Toxin B Subunit (Goat)
Breathing behaviour is subject to emotional regulation, but the underlying mechanisms remain unclear....
Design, performance, processing, and validation of a pooled CRISPR perturbation screen for bacterial toxins
Nature Protocols
Tian, S;Qin, Y;Wu, Y;Dong, M;
Product: Anti-Clostridium difficile Toxin B (Chicken lgY)
Unbiased forward genetic screens have been extensively employed in biological research to elucidate ....
A population of Insula neurons encodes for social preference only after acute social isolation in mice
Nature Communications
Glangetas, C;Guillaumin, A;Ladevèze, E;Braine, A;Gauthier, M;Bonamy, L;Doudnikoff, E;Dhellemmes, T;Landry, M;Bézard, E;Caille, S;Taupignon, A;Baufreton, J;Georges, F;
Product: Anti-Cholera Toxin B Subunit (Goat)
The Insula functions as a multisensory relay involved in socio-emotional processing with projections....
Encoding of cerebellar dentate neuronal activity during visual attention in rhesus macaques
Biorxiv
Flierman, N;Koay, S;van Hoogstraten, W;Ruigrok, T;Roelfsema, P;Badura, A;De Zeeuw, C;
Product: Anti-Cholera Toxin B Subunit (Goat)
The role of cerebellum in controlling eye movements is well established, but its contribution to mor....
Populations of hindbrain glucagon-like peptide 1 (GLP1) neurons that innervate the hypothalamic PVH, thalamic PVT, or limbic forebrain BST have axon collaterals that reach all central regions innervated by GLP1 neurons
The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience
Randolph, AB;Zheng, H;Rinaman, L;
Product: Anti-Cholera Toxin B Subunit (Goat)
Neurons in the caudal nucleus of the solitary tract (cNTS) and intermediate reticular nucleus (IRt) ....
Distributional coding of associative learning in discrete populations of midbrain dopamine neurons
Cell Reports
Avvisati, R;Kaufmann, AK;Young, CJ;Portlock, GE;Cancemi, S;Costa, RP;Magill, PJ;Dodson, PD;
Product: Anti-Cholera Toxin B Subunit (Goat)
Midbrain dopamine neurons are thought to play key roles in learning by conveying the difference betw....
Multimodal sensory control of motor performance by glycinergic interneurons of the mouse spinal cord deep dorsal horn
Neuron
Gradwell, MA;Ozeri-Engelhard, N;Eisdorfer, JT;Laflamme, OD;Gonzalez, M;Upadhyay, A;Medlock, L;Shrier, T;Patel, KR;Aoki, A;Gandhi, M;Abbas-Zadeh, G;Oputa, O;Thackray, JK;Ricci, M;George, A;Yusuf, N;Keating, J;Imtiaz, Z;Alomary, SA;Bohic, M;Haas, M;Hernandez, Y;Prescott, SA;Akay, T;Abraira, VE;
Product: Anti-Cholera Toxin B Subunit (Goat)
Sensory feedback is integral for contextually appropriate motor output, yet the neural circuits resp....
The Dorsal Column Nuclei Scales Mechanical Allodynia During Neuropathic Pain
Biorxiv
Upadhyay, A;Gradwell, M;Vajtay, T;Conner, J;Sayal, A;Azadegan, C;Patel, K;Thackary, J;Bohic, M;Imai, F;Ogundare, S;Yoshida, Y;Abdus-Saboor, I;Azim, E;Abraira, V;
Product: Anti-Cholera Toxin B Subunit (Goat)
Tactile perception relies on reliable transmission and modulation of low-threshold information as it....
Early Circulating Edema Factor in Inhalational Anthrax Infection: Does It Matter?
Microorganisms
Tessier, E;Cheutin, L;Garnier, A;Vigne, C;Tournier, JN;Rougeaux, C;
Product: Anti-Edema Factor from B. anthracis (Goat)
Anthrax toxins are critical virulence factors of Bacillus anthracis and Bacillus cereus strains that....
Disynaptic inhibitory cerebellar control over caudal medial accessory olive
Eneuro
van Hoogstraten, WS;Lute, MCC;Liu, Z;Broersen, R;Mangili, L;Kros, L;Gao, Z;Wang, X;van den Maagdenberg, AMJM;De Zeeuw, CI;
Product: Anti-Cholera Toxin B Subunit (Goat)
The olivocerebellar system, which is critical for sensorimotor performance and learning, functions t....
Parabrachial Neurons: Their Connections and Role in Maintaining Body Temperature, Wakefulness, and Appetite
Thesis
Grady, F;
Product: Anti-Cholera Toxin B Subunit (Goat)
Chronic Adaptations in the Dorsal Horn following a cervical spinal cord injury in primates
The Journal Of Neuroscience
Fisher, K;Garner, J;Darian-Smith, C;
Product: Anti-Cholera Toxin B Subunit (Goat)
Spinal cord injury (SCI) is devastating, with limited treatment options and variable outcomes. Most ....
Synaptic circuits involving gastrin-releasing peptide receptor-expressing neurons in the dorsal horn of the mouse spinal cord
Frontiers In Molecular Neuroscience
Quillet, R;Gutierrez-Mecinas, M;Polgár, E;Dickie, AC;Boyle, KA;Watanabe, M;Todd, AJ;
Product: Anti-Cholera Toxin B Subunit (Goat)
The superficial dorsal horn (SDH) of the spinal cord contains a diverse array of neurons. The vast m....
The circadian clock time tunes axonal regeneration
Cell Metabolism
De Virgiliis, F;Mueller, F;Palmisano, I;Chadwick, JS;Luengo-Gutierrez, L;Giarrizzo, A;Yan, Y;Danzi, MC;Picon-Muñoz, C;Zhou, L;Kong, G;Serger, E;Hutson, TH;Maldonado-Lasuncion, I;Song, Y;Scheiermann, C;Brancaccio, M;Di Giovanni, S;
Product: Anti-Cholera Toxin B Subunit (Goat)
Nerve injuries cause permanent neurological disability due to limited axonal regeneration. Injury-de....
A brainstem circuit for phonation and volume control in mice
Nature Neuroscience
Veerakumar, A;Head, JP;Krasnow, MA;
Product: Anti-Cholera Toxin B Subunit (Goat)
Mammalian vocalizations are critical for communication and are produced through the process of phona....
SPINAL V1 INHIBITORY INTERNEURON CLADES DIFFER IN BIRTHDATE, PROJECTIONS TO MOTONEURONS AND HETEROGENEITY
Biorxiv : The Preprint Server For Biology
Worthy, AE;Anderson, JT;Lane, AR;Gomez-Perez, L;Wang, AA;Griffith, RW;Rivard, AF;Bikoff, JB;Alvarez, FJ;
Product: Anti-Cholera Toxin B Subunit (Goat)
Spinal cord interneurons play a crucial role in shaping motor output, but their precise identity and....
Distinct roles of spinal commissural interneurons in transmission of contralateral sensory information
Current Biology
Laflamme, OD;Markin, SN;Deska-Gauthier, D;Banks, R;Zhang, Y;Danner, SM;Akay, T;
Product: Anti-Cholera Toxin B Subunit (Goat)
Crossed reflexes are mediated by commissural pathways transmitting sensory information to the contra....
Research on Detection of Ultra-Low Concentration Anthrax Protective Antigen Using Graphene Field-Effect Transistor Biosensor
Sensors
Liang, T;Chen, J;Yan, R;Jiang, H;Li, H;
Product: Anti-Protective Antigen from B. anthracis (Goat)
Protective antigen (PA) is an important biomarker for the early diagnosis of anthrax, and the accura....
Whole-brain monosynaptic inputs and outputs of leptin receptor b neurons of the nucleus tractus solitarii in mice
Brain Research Bulletin
Sun, L;Zhu, M;Wang, M;Hao, Y;Hao, Y;Jing, X;Yu, H;Shi, Y;Zhang, X;Wang, S;Yuan, F;Yuan, XS;
Product: Anti-Cholera Toxin B Subunit (Goat)
The nucleus tractus solitarii (NTS) is the primary central station that integrates visceral afferent....
Prox2 and Runx3 vagal sensory neurons regulate esophageal motility
Neuron
Lowenstein, ED;Ruffault, PL;Misios, A;Osman, KL;Li, H;Greenberg, RS;Thompson, R;Song, K;Dietrich, S;Li, X;Vladimirov, N;Woehler, A;Brunet, JF;Zampieri, N;Kühn, R;Liberles, SD;Jia, S;Lewin, GR;Rajewsky, N;Lever, TE;Birchmeier, C;
Product: Anti-Cholera Toxin B Subunit (Goat)
Vagal sensory neurons monitor mechanical and chemical stimuli in the gastrointestinal tract. Major e....
Lateral parabrachial FoxP2 neurons regulate respiratory responses to hypercapnia
Research Square
Kaur, S;Nicole, L;Sela, Y;Lima, J;Thomas, R;Bandaru, S;Saper, C;
Product: Anti-Cholera Toxin B Subunit (Goat)
Although CGRP neurons in the external lateral parabrachial nucleus (PBelCGRP neurons) are critical f....
Mediobasal hypothalamic neurons contribute to the control of brown adipose tissue sympathetic nerve activity and cutaneous vasoconstriction
Journal Of Thermal Biology
Mota, CMD;Madden, CJ;
Product: Anti-Cholera Toxin B Subunit (Goat)
The mediobasal hypothalamus (MBH) contains heterogeneous neuronal populations that regulate food int....
Two Ascending Thermosensory Pathways from the Lateral Parabrachial Nucleus That Mediate Behavioral and Autonomous Thermoregulation
Biorxiv
Yahiro, T;Kataoka, N;Nakamura, K;
Product: Anti-Cholera Toxin B Subunit (Goat)
Thermoregulatory behavior in homeothermic animals is an innate behavior to defend body core temperat....
Identification of an essential spinoparabrachial pathway for mechanical itch
Neuron
Ren, X;Liu, S;Virlogeux, A;Kang, SJ;Brusch, J;Liu, Y;Dymecki, SM;Han, S;Goulding, M;Acton, D;
Product: Anti-Cholera Toxin B Subunit (Goat)
The sensation of itch is a protective response that is elicited by either mechanical or chemical sti....
A melanopsin ganglion cell subtype forms a dorsal retinal mosaic projecting to the supraoptic nucleus
Nature Communications
Berry, MH;Moldavan, M;Garrett, T;Meadows, M;Cravetchi, O;White, E;Leffler, J;von Gersdorff, H;Wright, KM;Allen, CN;Sivyer, B;
Product: Anti-Cholera Toxin B Subunit (Goat)
Visual input to the hypothalamus from intrinsically photosensitive retinal ganglion cells (ipRGCs) i....
A rapid multiplex real-time PCR detection of toxigenic Clostridioides difficile directly from fecal samples
3 Biotech
Jia, XX;Wang, YY;Zhang, WZ;Li, WG;Bai, LL;Lu, JX;Ma, CF;Wu, Y;
Product: Anti-Clostridium difficile Toxin A (Chicken lgY)
This study developed a new single-tube multiplex real-time PCR method for detecting toxigenic C. dif....
The Pedunculopontine Tegmental Nucleus is not Important for Breathing Impairments Observed in a Parkinson’s Disease Model
Neuroscience
Miranda, NC;Oliveira, LM;Aquino, YC;Moreira, TS;Takakura, AC;
Product: Anti-Cholera Toxin B Subunit (Goat)
Parkinson’s disease (PD) is a motor disorder resulting from degeneration of dopaminergic neuro....
Connecting the esophagus to the brain: examining the role of Prox2 and Runx3 vagal sensory neurons in swallowing
Thesis
Lowenstein, ED;
Product: Anti-Cholera Toxin B Subunit (Goat)
Sensory neurons of the vagus nerve monitor distention, stretch and nutrients in the gastrointestinal....
Cerebellar inputs in the American alligator (Alligator mississippiensis)
Brain, Behavior And Evolution
Gutiérrez-Ibáñez, C;Kettler, L;Pilon, MC;Carr, CE;Wylie, DR;
Product: Anti-Cholera Toxin B Subunit (Goat)
Crocodilians (alligators, crocodiles and gharials) are the closet living relatives to birds, and as ....
Delayed viral vector mediated delivery of neurotrophin-3 improves skilled hindlimb function and stability after thoracic contusion
Experimental Neurology
Sydney-Smith, JD;Koltchev, AM;Moon, LDF;Warren, PM;
Product: Anti-Cholera Toxin B Subunit (Goat)
Intramuscular injection of an Adeno-associated viral vector serotype 1 (AAV1) encoding Neurotrophin-....
Convergent innervations of mesencephalic trigeminal and vestibular nuclei neurons onto oculomotor and pre-oculomotor neurons-Tract tracing and triple labeling in rats
Plos One
Chen, Y;Gong, X;Ibrahim, SIA;Liang, H;Zhang, J;
Product: Anti-Cholera Toxin B Subunit (Goat)
In studies of vestibulo-ocular reflex (VOR), the horizontal VOR circuit is much clearer than vertica....
Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants
Nature Communications
Tian, S;Xiong, X;Zeng, J;Wang, S;Tremblay, BJ;Chen, P;Chen, B;Liu, M;Chen, P;Sheng, K;Zeve, D;Qi, W;Breault, DT;RodrÃguez, C;Gerhard, R;Jin, R;Doxey, AC;Dong, M;
Product: Anti-Clostridium difficile Toxin B (Chicken lgY)
Toxin B (TcdB) is a major exotoxin responsible for diseases associated with Clostridioides difficile....
Lack of evidence for a role of anthrax toxin receptors as surface receptors for collagen VI and for its cleaved-off C5 domain/endotrophin
iScience
Przyklenk, M;Heumüller, SE;Freiburg, C;Lütke, S;Sengle, G;Koch, M;Paulsson, M;Schiavinato, A;Wagener, R;
Product: Anti-Protective Antigen from B. anthracis (Goat)
The microfibril-forming collagen VI is proteolytically cleaved and it was proposed that the released....
Descending pathways from the superior colliculus mediating autonomic and respiratory effects associated with orienting behaviour
The Journal of Physiology
Lynch, E;Dempsey, B;Saleeba, C;Monteiro, E;Turner, A;Burke, PG;Allen, AM;Dampney, RA;Hildreth, CM;Cornish, JL;Goodchild, AK;McMullan, S;
Product: Anti-Cholera Toxin B Subunit (Goat)
Neurons in the deep superior colliculus (dSC) integrate multimodal sensory signals to elicit context....
cATR Tracing Approach to Identify Individual Intermediary Neurons Based on Their Input and Output: A Proof-of-Concept Study Connecting Cerebellum and Central Hubs Implicated in Developmental Disorders
Cells
van Hoogstraten, WS;Lute, MCC;Nusselder, H;Kros, L;van den Maagdenberg, AMJM;De Zeeuw, CI;
Product: Anti-Cholera Toxin B Subunit (Goat)
Over the past decades, it has become increasingly clear that many neurodevelopmental disorders can b....
ER-Golgi-localized proteins TMED2 and TMED10 control the formation of plasma membrane lipid nanodomains
Developmental Cell
Anwar, MU;Sergeeva, OA;Abrami, L;Mesquita, FS;Lukonin, I;Amen, T;Chuat, A;Capolupo, L;Liberali, P;D'Angelo, G;van der Goot, FG;
Product: Anti-Protective Antigen from B. anthracis (Goat)
To promote infections, pathogens exploit host cell machineries such as structural elements of the pl....
Apyrase decreases phage induction and Shiga toxin release from E. coli O157:H7 and has a protective effect during infection
Gut Microbes
Arvidsson, I;Tontanahal, A;Johansson, K;Kristoffersson, AC;Kellnerová, S;Berger, M;Dobrindt, U;Karpman, D;
Product: Anti-Shiga Toxin, Camelid Antibody, VHH
Shiga toxin (Stx)-producing enterohemorrhagic Escherichia coli (EHEC) cause gastrointestinal infecti....
Chemogenetic activation of noradrenergic A5 neurons increases blood pressure and visceral sympathetic activity in adult rats
American Journal Of Physiology. Regulatory, Integrative And Comparative Physiology
Souza, GMPR;Stornetta, DS;Vitali, AJ;Wildner, H;Zeilhofer, HU;Campbell, JN;Abbott, SBG;
Product: Anti-Cholera Toxin B Subunit (Goat)
In mammals, the pontine noradrenergic system influences nearly every aspect of central nervous syste....
Small sensory spinal lesions that affect hand function in monkeys greatly alter primary afferent and motor neuron connections in the cord
The Journal Of Comparative Neurology
Fisher, KM;Garner, JP;Darian-Smith, C;
Product: Anti-Cholera Toxin B Subunit (Goat)
Small sensory spinal injuries induce plasticity across the neuraxis, but little is understood about ....
Methods for culturing adult CNS neurons reveal a CNS conditioning effect
Cell Reports Methods
van Niekerk, EA;Kawaguchi, R;Marques de Freria, C;Groeniger, K;Marchetto, MC;Dupraz, S;Bradke, F;Geschwind, DH;Gage, FH;Tuszynski, MH;
Product: Anti-Cholera Toxin B Subunit (Goat)
Neuronal cultures provide a basis for reductionist insights that rely on molecular and pharmacologic....
Saccadic premotor burst neurons and histochemical correlates of their firing patterns in rhesus monkey
Journal Of The Neurological Sciences
Mayadali, ÃS;Lienbacher, K;Shaikh, AG;Horn, AKE;
Product: Anti-Cholera Toxin B Subunit (Goat)
Bursting behavior of brainstem premotor burst neurons (BNs) is essential for initiation of saccades ....
Retrograde Axonal Transport of Liposomes from Peripheral Tissue to Spinal Cord and DRGs by Optimized Phospholipid and CTB Modification
International Journal Of Molecular Sciences
Fukui, T;Tateno, H;Nakamura, T;Yamada, Y;Sato, Y;Iwasaki, N;Harashima, H;Kadoya, K;
Product: Anti-Cholera Toxin B Subunit (Goat)
Despite recent advancements in therapeutic options for disorders of the central nervous system (CNS)....
Distinct morphology of cardiac- and brown adipose tissue-projecting neurons in the stellate ganglia of mice
Physiological Reports
Barrett, MS;Hegarty, DM;Habecker, BA;Aicher, SA;
Product: Anti-Cholera Toxin B Subunit (Goat)
Sympathetic neurons that innervate the heart are located primarily in the stellate ganglia (SG), whi....
Top-down control of hippocampal signal-to-noise by prefrontal long-range inhibition
Cell
Malik, R;Li, Y;Schamiloglu, S;Sohal, VS;
Product: Anti-Cholera Toxin B Subunit (Goat)
Prefrontal cortex (PFC) is postulated to exert “top-down control” on information process....
TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C.difficile
Cell
Luo, J;Yang, Q;Zhang, X;Zhang, Y;Wan, L;Zhan, X;Zhou, Y;He, L;Li, D;Jin, D;Zhen, Y;Huang, J;Li, Y;Tao, L;
Product: Anti-Clostridium difficile Toxin B (Chicken lgY)
The emergence of hypervirulent clade 2 Clostridioides difficile is associated with severe symptoms a....
Parcellation of the murine cortical hindlimb area is demonstrated by its subcortical connectivity and cytoarchitecture
The Journal Of Comparative Neurology
Kameda, H;Murabe, N;Mizukami, H;Ozawa, K;Hayashi, T;Sakurai, M;
Product: Anti-Cholera Toxin B Subunit (Goat)
Although corticospinal neurons are known to be distributed in both the primary motor and somatosenso....
Anatomical Characterization of Descending Projections of Lateral Hypothalamic Glutamatergic and GABAergic Neurons
Thesis
Lesser, J;
Product: Anti-Cholera Toxin B Subunit (Goat)
Important innate behaviors in mammals, such as sleep-wake regulation, arousal, eating, drinking, and....
Dopaminergic input from the posterior hypothalamus to the raphe pallidus area inhibits brown adipose tissue thermogenesis
American Journal Of Physiology. Regulatory, Integrative And Comparative Physiology
Conceição Furber, EPS;Mota, CMD;Veytsman, E;Morrison, SF;Madden, CJ;
Product: Anti-Cholera Toxin B Subunit (Goat)
Systemic administration of dopamine (DA) receptor agonists leads to falls in body temperature. Howev....
Input and output organization of the mesodiencephalic junction for cerebro-cerebellar communication
Journal of Neuroscience Research
Wang, X;Novello, M;Gao, Z;Ruigrok, TJH;De Zeeuw, CI;
Product: Anti-Cholera Toxin B Subunit (Goat)
Most studies investigating the impact of the cerebral cortex (CC) onto the cerebellum highlight the ....
Connections of the mouse subfornical region of the lateral hypothalamus (LHsf)
Brain Structure & Function
Ugur, M;Doridot, S;la Fleur, SE;Veinante, P;Massotte, D;
Product: Anti-Cholera Toxin B Subunit (Goat)
The lateral hypothalamus is a major integrative hub with a complex architecture characterized by int....
Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
Nature Communications
Chen, P;Zeng, J;Liu, Z;Thaker, H;Wang, S;Tian, S;Zhang, J;Tao, L;Gutierrez, CB;Xing, L;Gerhard, R;Huang, L;Dong, M;Jin, R;
Product: Anti-Clostridium difficile Toxin B (Chicken lgY)
C. difficile is a major cause of antibiotic-associated gastrointestinal infections. Two C. difficile....
Annexin Induces Cellular Uptake of Extracellular Vesicles and Delays Disease in Escherichia coli O157:H7 Infection
Microorganisms
Tontanahal, A;Arvidsson, I;Karpman, D;
Product: Anti-Shiga Toxin, Camelid Antibody, VHH
Enterohemorrhagic Escherichia coli secrete Shiga toxin and lead to hemolytic uremic syndrome. Patien....
Respiratory axon regeneration in the chronically injured spinal cord
Neurobiology Of Disease
Cheng, L;Sami, A;Ghosh, B;Goudsward, HJ;Smith, GM;Wright, MC;Li, S;Lepore, AC;
Product: Anti-Cholera Toxin B Subunit (Goat)
Promoting the combination of robust regeneration of damaged axons and synaptic reconnection of these....
Effect of dental malocclusion on cerebellar neuron activation via the dorsomedial part of the principal sensory trigeminal nucleus
European Journal Of Oral Sciences
Shi, M;Liu, X;Zhang, C;Zhang, H;Liu, Q;Wang, D;Liu, X;Li, J;Wang, M;
Product: Anti-Cholera Toxin B Subunit (Goat)
Occlusion has been proposed to play a role for body posture and balance, both of which are mediated ....
Projections from the ventral nucleus of the lateral lemniscus to the cochlea in the mouse
The Journal Of Comparative Neurology
Suthakar, K;Ryugo, DK;
Product: Anti-Cholera Toxin B Subunit (Goat)
Auditory efferents originate in the central auditory system and project to the cochlea. Although the....
Excitatory Impact of Dental Occlusion on Dorsal Motor Nucleus of Vagus
Frontiers In Neural Circuits
Liu, X;Shi, M;Ren, H;Xie, M;Zhang, C;Wang, D;Liu, X;Li, J;Wang, M;
Product: Anti-Cholera Toxin B Subunit (Goat)
Neurons in the trigeminal mesencephalic nucleus (Vme) have axons that branch peripherally to innerva....
Isolation and detection of a KDEL-tagged recombinant cholera toxin B subunit from Nicotiana benthamiana
Process Biochemistry
Morris, D;Reeves, M;Royal, J;Hamorsky, K;Matoba, N;
Product: Anti-Cholera Toxin B Subunit (Goat)
Here we describe refined methods for the isolation and detection of a KDEL-tagged, plant-produced re....
Reciprocal connectivity of the periaqueductal gray with the ponto-medullary respiratory network in rat
Brain Research
Trevizan-Baú, P;Furuya, WI;Mazzone, SB;Stanić, D;Dhingra, RR;Dutschmann, M;
Product: Anti-Cholera Toxin B Subunit (Goat)
Synaptic activities of the periaqueductal gray (PAG) can modulate or appropriate the respiratory mot....
Functional analyses of epidemic Clostridioides difficile toxin B variants reveal their divergence in utilizing receptors and inducing pathology
Plos Pathogens
Pan, Z;Zhang, Y;Luo, J;Li, D;Zhou, Y;He, L;Yang, Q;Dong, M;Tao, L;
Product: Anti-Clostridium difficile Toxin B (Chicken lgY)
Clostridioides difficile toxin B (TcdB) is a key virulence factor that causes C. difficile associate....
Product: Anti-Cholera Toxin B Subunit (Goat)
Patients with neurodegenerative diseases, such as Parkinsons, Alzheimers, and frontotemporal demen....
Neuroplasticity in NMDA receptor signaling in subregions of the rat rostral ventrolateral medulla following sedentary versus physically active conditions
The Journal Of Comparative Neurology
Fyk-Kolodziej, BE;Ghoddoussi, F;Mueller, PJ;
Product: Anti-Cholera Toxin B Subunit (Goat)
The rostral ventrolateral medulla (RVLM) is a brain region involved in normal regulation of the card....
A FN-MdV pathway and its role in cerebellar multimodular control of sensorimotor behavior
Nature Communications
Wang, X;Yu, SY;Ren, Z;De Zeeuw, CI;Gao, Z;
Product: Anti-Cholera Toxin B Subunit (Goat)
The cerebellum is crucial for various associative sensorimotor behaviors. Delay eyeblink conditionin....
Entopeduncular nucleus projections to the lateral habenula contribute to cocaine avoidance
The Journal Of Neuroscience
Li, H;Eid, M;Pullmann, D;Chao, YS;Thomas, AA;Jhou, TC;
Product: Anti-Cholera Toxin B Subunit (Goat)
The aversive properties associated with drugs of abuse influence both the development of addiction a....
Amygdala-Cortical Control of Striatal Plasticity Drives the Acquisition of Goal-Directed Action
Current Biology
Fisher, SD;Ferguson, LA;Bertran-Gonzalez, J;Balleine, BW;
Product: Anti-Cholera Toxin B Subunit (Goat)
In mammalian species, the capacity for goal-directed action relies on a process of cognitive-emotion....
Median preoptic area neurons are required for the cooling and febrile activations of brown adipose tissue thermogenesis in rat
Scientific Reports
da Conceio, EPS;Morrison, SF;Cano, G;Chiavetta, P;Tupone, D;
Product: Anti-Cholera Toxin B Subunit (Goat)
Within the central neural circuitry for thermoregulation, the balance between excitatory and inhibit....
Molecular Fingerprint and Developmental Regulation of the Tegmental GABAergic and Glutamatergic Neurons Derived from the Anterior Hindbrain
Cell Reports
Morello, F;Borshagovski, D;Survila, M;Tikker, L;Sadik-Ogli, S;Kirjavainen, A;Estarts, N;Knaapi, L;Lahti, L;Trnen, P;Mazutis, L;Delogu, A;Salminen, M;Achim, K;Partanen, J;
Product: Anti-Cholera Toxin B Subunit (Goat)
Tegmental nuclei in the ventral midbrain and anterior hindbrain control motivated behavior, mood, me....
A Replicating Single-Cycle Adenovirus Vaccine Effective against Clostridium difficile
Vaccines
Matchett, WE;Anguiano-Zarate, S;Malewana, GBR;Mudrick, H;Weldy, M;Evert, C;Khoruts, A;Sadowsky, M;Barry, MA;
Product: Anti-Clostridium difficile Toxin B (Chicken lgY)
Clostridium difficile causes nearly 500,000 infections and nearly 30,000 deaths each year in the U.S....
Intrinsic control of neuronal diversity and synaptic specificity in a proprioceptive circuit
eLife
Shin, MM;Catela, C;Dasen, J;
Product: Anti-Cholera Toxin B Subunit (Goat)
Relay of muscle-derived sensory information to the CNS is essential for the execution of motor behav....
Respiratory pathology in the Optn-/- mouse model of Amyotrophic Lateral Sclerosis
Respiratory Physiology & Neurobiology
McCall, AL;Dhindsa, JS;Pucci, LA;Kahn, AF;Fusco, AF;Biswas, DD;Strickland, LM;Tseng, HC;ElMallah, MK;
Product: Anti-Cholera Toxin B Subunit (Goat)
Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disorder that results in deat....
Proprioceptive thalamus receiving forelimb and neck muscle spindle inputs via the external cuneate nucleus in the rat
Brain Structure & Function
Uemura, Y;Haque, T;Sato, F;Tsutsumi, Y;Ohara, H;Oka, A;Furuta, T;Bae, YC;Yamashiro, T;Tachibana, Y;Yoshida, A;
Product: Anti-Cholera Toxin B Subunit (Goat)
Proprioceptive signals from body muscles have historically been considered to project to the rostrod....
Substance P-expressing Neurons in the Superficial Dorsal Horn of the Mouse Spinal Cord: Insights into Their Functions and their Roles in Synaptic Circuits
Neuroscience
Polgr, E;Bell, AM;Gutierrez-Mecinas, M;Dickie, AC;Akar, O;Costreie, M;Watanabe, M;Todd, AJ;
Product: Anti-Cholera Toxin B Subunit (Goat)
The tachykinin peptide substance P (SP) is expressed by many interneurons and some projection neuron....
Functional segregation within the pelvic nerve of male rats: a meso- and microscopic analysis
Journal Of Anatomy
Bertrand, MM;Korajkic, N;Osborne, PB;Keast, JR;
Product: Anti-Cholera Toxin B Subunit (Goat)
The pelvic splanchnic nerves are essential for pelvic organ function and have been proposed as targe....
Leptin increases sympathetic nerve activity via induction of its own receptor in the paraventricular nucleus
Elife
Shi, Z;Pelletier, NE;Wong, J;Li, B;Sdrulla, AD;Madden, CJ;Marks, DL;Brooks, VL;
Product: Anti-Cholera Toxin B Subunit (Goat)
Whether leptin acts in the paraventricular nucleus (PVN) to increase sympathetic nerve activity (SNA....
Ethnicity-Specific Differences in Liver Transplant Outcomes Among Adults With Primary Sclerosing Cholangitis: 20052017 United Network for Organ Sharing/Organ Procurement and Transplantation Network
Journal Of Clinical And Experimental Hepatology
Bayable, A;Ohabughiro, M;Cheung, R;Wong, R;
Product: Anti-Cholera Toxin B Subunit (Goat)
Background & aims Lack of effective medical therapies for primary sclerosing cholangitis (PSC) l....
Ligand Binding to the Collagen VI Receptor Triggers a Talin-to-RhoA Switch that Regulates Receptor Endocytosis
Developmental Cell
Brgi, J;Abrami, L;Castanon, I;Abriata, LA;Kunz, B;Yan, SE;Lera, M;Unger, S;Superti-Furga, A;Peraro, MD;Gaitan, MG;van der Goot, FG;
Product: Anti-Protective Antigen from B. anthracis (Goat)
Capillary morphogenesis gene 2 (CMG2/ANTXR2) is a cell surface receptor for both collagen VI and ant....
Direct Parabrachial-Cortical Connectivity
Cerebral Cortex
Grady, F;Peltekian, L;Iverson, G;Geerling, JC;
Product: Anti-Cholera Toxin B Subunit (Goat)
The parabrachial nucleus (PB) in the upper brain stem tegmentum includes several neuronal subpopulat....
Neonatal injury evokes persistent deficits in dynorphin inhibitory circuits within the adult mouse superficial dorsal horn
The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience
Brewer, CL;Li, J;O'Conor, K;Serafin, EK;Baccei, ML;
Product: Anti-Cholera Toxin B Subunit (Goat)
Neonatal tissue damage induces long-term deficits in inhibitory synaptic transmission within the spi....
Anisotropic Alginate Hydrogels Promote Axonal Growth across Chronic Spinal Cord Transections after Scar Removal
ACS Biomaterials Science & Engineering
Huang, L;Wang, Y;Zhu, M;Wan, X;Zhang, H;Lei, T;Blesch, A;Liu, S;
Product: Anti-Cholera Toxin B Subunit (Goat)
We have previously reported that cell-seeded alginate hydrogels (AHs) with anisotropic capillaries c....
Restoring Cellular Energetics Promotes Axonal Regeneration and Functional Recovery after Spinal Cord Injury
Cell Metabolism
Han, Q;Xie, Y;Ordaz, JD;Huh, AJ;Huang, N;Wu, W;Liu, N;Chamberlain, KA;Sheng, ZH;Xu, XM;
Product: Anti-Cholera Toxin B Subunit (Goat)
Axonal regeneration in the central nervous system (CNS) is a highly energy-demanding process. Extrin....
Individual mesopontine neurons implicated in anesthetic loss-of-consciousness employ separate ascending pathways to the cerebral cortex
Neuroscience
Lellouche, Y;Minert, A;Schreiber, C;Aroch, I;Vaso, K;Fishman, Y;Devor, M;
Product: Anti-Cholera Toxin B Subunit (Goat)
The mesopontine tegmental anesthesia area (MPTA) is a small brainstem nucleus that, when exposed to ....
Npas1+-Nkx2.1+ Neurons Are an Integral Part of the Cortico-pallido-cortical Loop
The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience
Abecassis, ZA;Berceau, BL;Win, PH;Garca, D;Xenias, HS;Cui, Q;Pamukcu, A;Cherian, S;Hernndez, VM;Chon, U;Lim, BK;Kim, Y;Justice, NJ;Awatramani, R;Hooks, BM;Gerfen, CR;Boca, SM;Chan, CS;
Product: Anti-Cholera Toxin B Subunit (Goat)
Within the basal ganglia circuit, the external globus pallidus (GPe) is critically involved in motor....
A Novel FN-MdV Pathway and Its Role in Cerebellar Multimodular Control of Sensorimotor Behavior
Research Square
Wang, X;Yu, S;Ren, Z;De Zeeuw, CI;Gao, Z;
Product: Anti-Cholera Toxin B Subunit (Goat)
The cerebellum is crucial for various associative sensorimotor behaviors. Delay 18 eyeblink conditio....
Cutaneous Inputs to Dorsal Column Nuclei in Adult Macaque Monkeys Subjected to Unilateral Lesion of the Primary Motor Cortex or of the Cervical Spinal Cord and Treatments Promoting Axonal Growth
Neuroscience Insights
Savidan, J;Beaud, M;Rouiller, E;
Product: Anti-Cholera Toxin B Subunit (Goat)
The highly interconnected somatosensory and motor systems are subjected to connectivity changes at c....
Descending motor circuitry required for NT-3 mediated locomotor recovery after spinal cord injury in mice
Nature Communications
Han, Q;Ordaz, JD;Liu, NK;Richardson, Z;Wu, W;Xia, Y;Qu, W;Wang, Y;Dai, H;Zhang, YP;Shields, CB;Smith, GM;Xu, XM;
Product: Anti-Cholera Toxin B Subunit (Goat)
Locomotor function, mediated by lumbar neural circuitry, is modulated by descending spinal pathways.....
Influence of the phosphoenolpyruvate:carbohydrate phosphotransferase system on toxin gene expression and virulence in Bacillus anthracis
Molecular Microbiology
Bier, N;Hammerstrom, TG;Koehler, TM;
Product: Anti-Edema Factor from B. anthracis (Goat)
AtxA, the master virulence gene regulator of Bacillus anthracis, is a PRD-Containing Virulence Regul....
Neural control of fasting-induced torpor in mice
Scientific Reports
Hitrec, T;Luppi, M;Bastianini, S;Squarcio, F;Berteotti, C;Lo Martire, V;Martelli, D;Occhinegro, A;Tupone, D;Zoccoli, G;Amici, R;Cerri, M;
Product: Anti-Cholera Toxin B Subunit (Goat)
Torpor is a peculiar mammalian behaviour, characterized by the active reduction of metabolic rate, f....
Reorganization of the Primate Dorsal Horn in Response to a Deafferentation Lesion Affecting Hand Function
Biorxiv
Fisher, KM;Garner, J;Darian-Smith, CJ;
Product: Anti-Cholera Toxin B Subunit (Goat)
The loss of sensory input following a spinal deafferentation injury can be debilitating, and this is....
hESC-Derived Dopaminergic Transplants Integrate into Basal Ganglia Circuitry in a Preclinical Model of Parkinson’s Disease
Cell Reports
Adler, AF;Cardoso, T;Nolbrant, S;Mattsson, B;Hoban, DB;Jarl, U;Wahlestedt, JN;Grealish, S;Bjrklund, A;Parmar, M;
Product: Anti-Cholera Toxin B Subunit (Goat)
Cell replacement is currently being explored as a therapeutic approach for neurodegenerative disease....
Parallel organization of the avian sensorimotor arcopallium: Tectofugal visual Pathway in the pigeon (Columba livia)
The Journal Of Comparative Neurology
Fernndez, M;Morales, C;Durn, E;Fernandez-Colleman, S;Sentis, E;Mpodozis, J;Karten, HJ;Marn, GJ;
Product: Anti-Cholera Toxin B Subunit (Goat)
The sensory-motor division of the avian arcopallium receives parallel inputs from primary and high o....
Three Rostromedial Tegmental Afferents Drive Triply Dissociable Aspects of Punishment Learning and Aversive Valence Encoding
Neuron
Li, H;Vento, PJ;Parrilla-Carrero, J;Pullmann, D;Chao, YS;Eid, M;Jhou, TC;
Product: Anti-Cholera Toxin B Subunit (Goat)
Persistence of reward seeking despite punishment or other negative consequences is a defining featur....
An open cortico-basal ganglia loop allows limbic control over motor output via the nigrothalamic pathway
Elife
Aoki, S;Smith, JB;Li, H;Yan, X;Igarashi, M;Coulon, P;Wickens, JR;Ruigrok, TJ;Jin, X;
Product: Anti-Cholera Toxin B Subunit (Goat)
Cortico-basal ganglia-thalamocortical loops are largely conceived as parallel circuits that process ....
Long-distance axon regeneration promotes recovery of diaphragmatic respiratory function after spinal cord injury
Eneuro
Urban, MW;Ghosh, B;Block, CG;Strojny, LR;Charsar, BA;Goulo, M;Komaravolu, SS;Smith, GM;Wright, MC;Li, S;Lepore, AC;
Product: Anti-Cholera Toxin B Subunit (Goat)
Compromise in inspiratory breathing following cervical spinal cord injury (SCI) is caused by damage ....
Expression of Neuropeptide FF Defines a Population of Excitatory Interneurons in the Superficial Dorsal Horn of the Mouse Spinal Cord that Respond to Noxious and Pruritic Stimuli
Neuroscience
Gutierrez-Mecinas, M;Bell, A;Polgr, E;Watanabe, M;Todd, AJ;
Product: Anti-Cholera Toxin B Subunit (Goat)
The great majority of neurons in the superficial dorsal horn of the spinal cord are excitatory inter....
Intratelencephalic projections of the avian visual dorsal ventricular ridge: Laminarly segregated, reciprocally and topographically organized
The Journal Of Comparative Neurology
Fernndez, M;Ahumada-Galleguillos, P;Sentis, E;Marn, G;Mpodozis, J;
Product: Anti-Cholera Toxin B Subunit (Goat)
Recent reports have shown that the avian visual dorsal ventricular ridge (DVR) is organized as a tri....
PTP inhibitory peptide promotes recovery of diaphragm function and sprouting of bulbospinal respiratory axons following cervical spinal cord injury
Journal Of Neurotrauma
Urban, MW;Ghosh, B;Block, CG;Charsar, BA;Smith, GM;Wright, MC;Li, S;Lepore, AC;
Product: Anti-Cholera Toxin B Subunit (Goat)
Damage to respiratory neural circuitry and consequent loss of diaphragm function is a major cause of....
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