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Oral Exposure to Clostridium difficile Toxin A Aggravates Food Allergy by Intestinal Barrier Destruction, Mast Cell Activation, and Th2-Biased Immune Responses
Journal Of Agricultural And Food Chemistry
Xu, X;He, C;Yuan, J;Gao, J;Meng, X;Wu, Y;Li, X;Tong, P;Chen, H;;
Product: Toxin A from Clostridium difficile
Food allergy is a complex disease, with multiple environmental factors involved. Considering the reg....
Design, performance, processing, and validation of a pooled CRISPR perturbation screen for bacterial toxins
Nature Protocols
Tian, S;Qin, Y;Wu, Y;Dong, M;
Product: Anti-Clostridium difficile Toxin B (Chicken lgY)
Unbiased forward genetic screens have been extensively employed in biological research to elucidate ....
Genomic epidemiology of Clostridioides difficile Sequence Type 35 reveals intraspecies and interspecies clonal transmission
Emerging Microbes & Infections
Luo, Y;Chen, Y;Lin, S;Hu, H;Song, X;Bian, Q;Fang, W;Lv, H;Wang, Q;Jiang, J;Tang, YW;Jin, D;
Product: Toxin B from Clostridium difficile
Clostridioides difficile sequence type (ST) 35 has been found in humans and animals worldwide. Howev....
Gut microbiome changes in mouse, Mongolian gerbil, and hamster models following Clostridioides difficile challenge
Frontiers In Microbiology
Wan, S;You, P;Shi, Q;Hu, H;Zhang, L;Chen, L;Wu, Z;Lin, S;Song, X;Luo, Y;Wang, Y;Ju, F;Jin, D;Chen, Y;
Product: Toxin B from Clostridium difficile
Clostridioides difficile infection (CDI), as well as its etiology and pathogenesis, have been extens....
Defined microbial communities and their soluble products protect mice from Clostridioides difficile infection
Communications Biology
Douchant, K;He, SM;Noordhof, C;Greenlaw, J;Vancuren, S;Schroeter, K;Allen-Vercoe, E;Sjaarda, C;Vanner, SJ;Petrof, EO;Sheth, PM;Guzman, M;
Product: Toxin A from Clostridium difficile
Clostridioides difficile is the leading cause of antibiotic-associated infectious diarrhea. The deve....
Multimodal vaccination targeting the receptor binding domains of Clostridioides difficile toxins A and B with an attenuated Salmonella Typhimurium vector (YS1646) protects mice from lethal challenge
Microbiology Spectrum
Winter, K;Houle, S;Dozois, CM;Ward, BJ;
Product: Toxin A from Clostridium difficile
Clostridioides difficile remains a major public health threat, and new approaches are needed to deve....
Evaluation of an in vitro experimental platform of human polarized intestinal epithelial monolayers for the hazard assessment of insecticidal proteins
Food And Chemical Toxicology : An International Journal Published For The British Industrial Biological Research Association
Zimmermann, CS;Snow, RF;Wilson-Mifsud, B;LeRoy, K;Boeckman, C;Huang, E;Mathesius, CA;Roper, JM;Hurley, BP;
Product: Toxin B from Clostridium difficile
Previous work demonstrated the utility of using human-derived intestinal epithelial cell (IEC) lines....
Applications of High-Throughput DNA Sequencing to Single-Domain Antibody Discovery and Engineering
Methods in Molecular Biology
Lowden, MJ;Lei, EK;Hussack, G;Henry, KA;
Product: Toxin A from Clostridium difficile
Next-generation DNA sequencing (NGS) technologies have made it possible to interrogate antibody repe....
The microbial derived bile acid lithocholate and its epimers inhibit Clostridioides difficile growth and pathogenicity while sparing members of the gut microbiota
Biorxiv : The Preprint Server For Biology
Kisthardt, SC;Thanissery, R;Pike, CM;Foley, MH;Theriot, CM;
Product: Toxin A from Clostridium difficile
C. difficile infection (CDI) is associated with antibiotic usage, which disrupts the indigenous gut ....
A rapid multiplex real-time PCR detection of toxigenic Clostridioides difficile directly from fecal samples
3 Biotech
Jia, XX;Wang, YY;Zhang, WZ;Li, WG;Bai, LL;Lu, JX;Ma, CF;Wu, Y;
Product: Anti-Clostridium difficile Toxin A (Chicken lgY)
This study developed a new single-tube multiplex real-time PCR method for detecting toxigenic C. dif....
Structure-guided design of a potent Clostridiodes difficile toxin A inhibitor
Frontiers In Microbiology
Hussack, G;Rossotti, MA;van Faassen, H;Murase, T;Eugenio, L;Schrag, JD;Ng, KK;Tanha, J;
Product: Toxin A from Clostridium difficile
Crystal structures of camelid heavy-chain antibody variable domains (VHHs) bound to fragments of the....
Targeting the Toxin B glucosyltransferase domain of NAP1/B1/027 Clostridioides difficile using an attenuated Salmonella enterica Typhimurium vaccine vector
Thesis
Upadhyaya, P;
Product: Toxin B from Clostridium difficile
Clostridioides difficile (C. difficile) is the most common cause of nosocomial antibiotic-associated....
Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants
Nature Communications
Tian, S;Xiong, X;Zeng, J;Wang, S;Tremblay, BJ;Chen, P;Chen, B;Liu, M;Chen, P;Sheng, K;Zeve, D;Qi, W;Breault, DT;RodrÃguez, C;Gerhard, R;Jin, R;Doxey, AC;Dong, M;
Product: Anti-Clostridium difficile Toxin B (Chicken lgY)
Toxin B (TcdB) is a major exotoxin responsible for diseases associated with Clostridioides difficile....
Identification of ADS024, a newly characterized strain of Bacillus velezensis with direct Clostridiodes difficile killing and toxin degradation bio-activities
Scientific Reports
O'Donnell, MM;Hegarty, JW;Healy, B;Schulz, S;Walsh, CJ;Hill, C;Ross, RP;Rea, MC;Farquhar, R;Chesnel, L;
Product: Toxin B from Clostridium difficile
Clostridioides difficile infection (CDI) remains a significant health threat worldwide. C. difficile....
Product: Toxin A from Clostridium difficile
The gastrointestinal ecosystem is formed from interactions between the host, indigenous gut microbio....
TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C.difficile
Cell
Luo, J;Yang, Q;Zhang, X;Zhang, Y;Wan, L;Zhan, X;Zhou, Y;He, L;Li, D;Jin, D;Zhen, Y;Huang, J;Li, Y;Tao, L;
Product: Anti-Clostridium difficile Toxin B (Chicken lgY)
The emergence of hypervirulent clade 2 Clostridioides difficile is associated with severe symptoms a....
Facile Affinity Maturation of Single-Domain Antibodies Using Next-Generation DNA Sequencing
Methods In Molecular Biology
Lowden, MJ;van Faassen, H;Raphael, S;Ryan, S;Hussack, G;Henry, KA;
Product: Toxin A from Clostridium difficile
Binding affinity is one of the primary determinants of antibody function. Here, we provide a protoco....
Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues
Nature Communications
Paparella, AS;Aboulache, BL;Harijan, RK;Potts, KS;Tyler, PC;Schramm, VL;
Product: Toxin A from Clostridium difficile
Clostridium difficile causes life-threatening diarrhea and is the leading cause of healthcare-associ....
Ebselen Not Only Inhibits Clostridioides difficile Toxins but Displays Redox-Associated Cellular Killing
Microbiology Spectrum
Marreddy, RKR;Olaitan, AO;May, JN;Dong, M;Hurdle, JG;
Product: Toxin B from Clostridium difficile
Ebselen, a reactive organoselenium compound, was shown to inhibit toxins TcdA and TcdB by covalently....
Development and clinical validation of an automated cell cytotoxicity neutralization assay for detecting Clostridioides difficile toxins in clinically relevant stools samples
Anaerobe
A, E;Wv, K;R, F;H, N;C, T;S, S;Mh, W;K, D;Kutzler, MA;Ku, J;A, A;Mw, P;
Product: Toxin A from Clostridium difficile
Objectives To improve the diagnostic accuracy of Clostridioides difficile infection, current U.S. an....
TIM-3 restrains anti-tumour immunity by regulating inflammasome activation
Nature
Dixon, KO;Tabaka, M;Schramm, MA;Xiao, S;Tang, R;Dionne, D;Anderson, AC;Rozenblatt-Rosen, O;Regev, A;Kuchroo, VK;
Product: Toxin A from Clostridium difficile
T cell immunoglobulin and mucin-containing molecule 3 (TIM-3), first identified as a molecule expres....
Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection
Nature Communications
Chen, P;Zeng, J;Liu, Z;Thaker, H;Wang, S;Tian, S;Zhang, J;Tao, L;Gutierrez, CB;Xing, L;Gerhard, R;Huang, L;Dong, M;Jin, R;
Product: Anti-Clostridium difficile Toxin B (Chicken lgY)
C. difficile is a major cause of antibiotic-associated gastrointestinal infections. Two C. difficile....
Clostridioides difficile toxins enhanced the in vitro production of CXC chemokine ligand 2 and tumor necrosis factor-α via Toll-like receptors in macrophages
Journal Of Medical Microbiology
McKee, HK;Kajiwara, C;Yamaguchi, T;Ishii, Y;Shimizu, N;Ohara, A;Tateda, K;
Product: Toxin B from Clostridium difficile
Introduction. Clostridioides difficile infection (CDI) causes toxin-mediated enteropathy, such as an....
The autophagic response to Staphylococcus aureus provides an intracellular niche in neutrophils
Autophagy
Prajsnar, TK;Serba, JJ;Dekker, BM;Gibson, JF;Masud, S;Fleming, A;Johnston, SA;Renshaw, SA;Meijer, AH;
Product: Toxin B from Clostridium difficile
Staphylococcus aureus is a major human pathogen causing multiple pathologies, from cutaneous lesions....
Protection from Lethal Clostridioides difficile Infection via Intraspecies Competition for Cogerminant
mBio
Leslie, JL;Jenior, ML;Vendrov, KC;Standke, AK;Barron, MR;O'Brien, TJ;Unverdorben, L;Thaprawat, P;Bergin, IL;Schloss, PD;Young, VB;
Product: Toxin A from Clostridium difficile
Clostridioides difficile, a Gram-positive, spore-forming bacterium, is the primary cause of infectio....
Endotoxin acts synergistically with C. difficile toxin B to increase IL-1 ? production: A potential role for the intestinal biome in modifying the severity of C. difficile colitis
The Journal Of Infectious Diseases
Htwe, P;Aung, HH;Kywe, B;Niang, PT;Oo, TS;Monhandas, S;Kelly, L;Goldman, DL;
Product: Toxin B from Clostridium difficile
Background Inflammation is a crucial driver of host damage in patients with C. difficile colitis. We....
Rapid Flow Cytometry-Based Assay for the Functional Classification of MEFV Variants
Journal Of Clinical Immunology
Honda, Y;Maeda, Y;Izawa, K;Shiba, T;Tanaka, T;Nakaseko, H;Nishimura, K;Mukoyama, H;Isa-Nishitani, M;Miyamoto, T;Nihira, H;Shibata, H;Hiejima, E;Ohara, O;Takita, J;Yasumi, T;Nishikomori, R;
Product: Toxin A from Clostridium difficile
Purpose Pathogenic MEFV variants cause pyrin-associated autoinflammatory diseases (PAADs), which inc....
New ribotype Clostridioides difficile from ST11 group revealed higher pathogenic ability than RT078
Emerging Microbes & Infections
Gu, W;Wang, W;Li, W;Li, N;Wang, Y;Zhang, W;Lu, C;Tong, P;Han, Y;Sun, X;Lu, J;Wu, Y;Dai, J;
Product: Toxin A from Clostridium difficile
Clostridioides difficile is the predominant antibiotic-associated enteropathogen associated with dia....
Functional analyses of epidemic Clostridioides difficile toxin B variants reveal their divergence in utilizing receptors and inducing pathology
Plos Pathogens
Pan, Z;Zhang, Y;Luo, J;Li, D;Zhou, Y;He, L;Yang, Q;Dong, M;Tao, L;
Product: Anti-Clostridium difficile Toxin B (Chicken lgY)
Clostridioides difficile toxin B (TcdB) is a key virulence factor that causes C. difficile associate....
Anti-toxin antibody is not associated with recurrent Clostridium difficile infection
Anaerobe
Gilbert, J;Leslie, J;Putler, R;Weiner, S;Standke, A;Penkevich, A;Keidan, M;Young, VB;Rao, K;
Product: Toxin A from Clostridium difficile
Clostridium difficile infection (CDI) recurs in ∼20% of patients. Prior studies indicated that antib....
RhoA/ROCKs signalling is increased by treatment with TKI-258 and leads to increased apoptosis in of SCC-4 oral squamous cell carcinoma cell line
Journal Of Oral Pathology & Medicine : Official Publication Of The International Association Of Oral Pathologists And The American Academy Of Oral Pathology
Carneiro, ACDM;De Vito, FB;Moraes-Souza, H;Crema, VO;
Product: Toxin A from Clostridium difficile
Background This study evaluated the effect of treatment with TKI‐258 on apoptosis, involving Rho GTP....
Irgm2 and Gate-16 cooperatively dampen Gram-negative bacteria-induced caspase-11 response
EMBO Reports
Eren, E;Plans, R;Bagayoko, S;Bordignon, PJ;Chaoui, K;Hessel, A;Santoni, K;Pinilla, M;Lagrange, B;Burlet-Schiltz, O;Howard, JC;Henry, T;Yamamoto, M;Meunier, E;
Product: Toxin B from Clostridium difficile
Inflammatory caspase-11 (rodent) and caspases-4/5 (humans) detect the Gram-negative bacterial compon....
C.difficile carriage in animals and the associated changes in the host fecal microbiota
Anaerobe
Thanissery, R;McLaren, MR;Rivera, A;Reed, AD;Betrapally, NS;Burdette, T;Winston, JA;Jacob, M;Callahan, BJ;Theriot, CM;
Product: Toxin B from Clostridium difficile
The relationship between the gut microbiota and Clostridioides difficile, and its role in the severi....
RIPK3 Promotes Mefv Expression and Pyrin Inflammasome Activation via Modulation of mTOR Signaling
Journal Of Immunology
Sharma, D;Malik, A;Balakrishnan, A;Malireddi, RKS;Kanneganti, TD;
Product: Toxin B from Clostridium difficile
Mutations in MEFV, the gene encoding pyrin in humans, are associated with the autoinflammatory disor....
A Replicating Single-Cycle Adenovirus Vaccine Effective against Clostridium difficile
Vaccines
Matchett, WE;Anguiano-Zarate, S;Malewana, GBR;Mudrick, H;Weldy, M;Evert, C;Khoruts, A;Sadowsky, M;Barry, MA;
Product: Anti-Clostridium difficile Toxin B (Chicken lgY)
Clostridium difficile causes nearly 500,000 infections and nearly 30,000 deaths each year in the U.S....
Response of the gut microbiota during the Clostridioides difficile infection in tree shrews mimics those in humans
BMC Microbiology
Gu, W;Li, W;Wang, W;Kuang, D;Zhang, W;Lu, C;Li, N;Tong, P;Han, Y;Sun, X;Lu, J;Wu, Y;Dai, J;
Product: Toxin A from Clostridium difficile
Clostridioides difficile is a major cause of antibiotic associated diarrhea. Several animal models a....
Structure and Function of Bovine Whey Derived Oligosaccharides Showing Synbiotic Epithelial Barrier Protective Properties
Nutrients
Duncan, PI;Aitio, O;Heiskanen, A;Niemel, R;Saarinen, J;Helin, J;Porta, N;Fiaux, M;Monnoz, D;Golliard, M;Cherbut, C;Berrocal, R;Austin, S;Sprenger, N;
Product: Toxin A from Clostridium difficile
Commensal gut microbiota and probiotics have numerous effects on the host’s metabolic and protective....
Salicylanilide Analog Minimizes Relapse of Clostridioides difficile Infection in Mice
Journal Of Medicinal Chemistry
Blake, S;Thanissery, R;Rivera, AJ;Hixon, MS;Lin, M;Theriot, CM;Janda, KD;
Product: Toxin A from Clostridium difficile
Clostridioides difficile infection (CDI) causes serious and sometimes fatal symptoms like diarrhea a....
Inactivation of Rho GTPases by Burkholderia cenocepacia Induces a WASH-Mediated Actin Polymerization that Delays Phagosome Maturation
Cell Reports
Walpole, GFW;Plumb, JD;Chung, D;Tang, B;Boulay, B;Osborne, DG;Piotrowski, JT;Catz, SD;Billadeau, DD;Grinstein, S;Jaumouill, V;
Product: Toxin B from Clostridium difficile
Burkholderia cenocepacia is an opportunistic bacterial pathogen that causes severe pulmonary infecti....
Human intestinal enteroids as a model of Clostridioides difficile-induced enteritis
American Journal Of Physiology. Gastrointestinal And Liver Physiology
Engevik, MA;Danhof, HA;Chang-Graham, AL;Spinler, JK;Engevik, KA;Herrmann, B;Endres, BT;Garey, KW;Hyser, JM;Britton, RA;Versalovic, J;
Product: Toxin A from Clostridium difficile
Clostridioides difficile is an important nosocomial pathogen that produces toxins to cause life-thre....
Serum albumin-binding VH Hs with variable pH sensitivities enable tailored half-life extension of biologics
FASEB Journal : Official Publication Of The Federation Of American Societies For Experimental Biology
van Faassen, H;Ryan, S;Henry, KA;Raphael, S;Yang, Q;Rossotti, MA;Brunette, E;Jiang, S;Haqqani, AS;Sulea, T;MacKenzie, CR;Tanha, J;Hussack, G;
Product: Toxin A from Clostridium difficile
Prolonged serum half-life is required for the efficacy of most protein therapeutics. One strategy fo....
Ontogeny and function of the circadian clock in intestinal organoids
Biorxiv
Rosselot, A;Park, M;Matsu-Ura, T;Wu, G;Flores, D;Subramanian, K;Lee, S;Sundaram, N;Broda, T;McCauley, H;Hawkins, J;Chetal, K;Salomonis, N;Shroyer, N;Helmrath, M;Wells, J;Hogenesch, J;Moore, S;Hong, C;
Product: Toxin B from Clostridium difficile
Circadian rhythms regulate diverse aspects of gastrointestinal physiology ranging from the compositi....
Tissue Responses to Shiga Toxin in Human Intestinal Organoids
Cellular And Molecular Gastroenterology And Hepatology
Pradhan, S;Karve, SS;Weiss, AA;Hawkins, J;Poling, HM;Helmrath, MA;Wells, JM;McCauley, HA;
Product: Toxin B from Clostridium difficile
Shiga toxin (Stx)-producing Escherichia coli (eg, O157:H7) infection produces bloody diarrhea, while....
Matrix stiffness regulates endosomal escape of uropathogenic E. coli
Cellular Microbiology
Moorthy, S;Byfield, FJ;Janmey, PA;Klein, EA;
Product: Toxin B from Clostridium difficile
Uropathogenic E. coli (UPEC) infection in vivo is characterized by invasion of bladder umbrella epit....
Effect of restricted dissolved oxygen on expression of Clostridium difficile toxin A subunit from E. coli
Scientific Reports
Sharma, AK;Phue, J;Khatipov, E;Dalal, N;Anderson, ED;Shiloach, J;
Product: Toxin A from Clostridium difficile
The repeating unit of the C. difficile Toxin A (rARU, also known as CROPS [combined repetitive oligo....
Ursodeoxycholic acid (UDCA) mitigates the host inflammatory response during Clostridioides difficile infection by altering gut bile acids which attenuates NF-B signaling via bile acid activated receptors
Biorxiv
Winston, JA;Rivera, AM;Cai, J;Thanissery, RM;
Product: Toxin A from Clostridium difficile
Clostridioides difficile infection (CDI) is associated with increasing morbidity and mortality posin....
Rho GTPases are Involved on Regulation of Cytodifferentiation of SCC-4 Oral Squamous Cell Carcinoma Cell Line: A Preliminary Study
Asian Pacific Journal Of Cancer Prevention : APJCP
Pineiro, NM;Carneiro, ACDM;Crema, VO;
Product: Toxin A from Clostridium difficile
Objective: This study evaluated the involvement of Rho GTPases proteins in the regulation of cytodif....
Irgm2 and Gate-16 cooperatively dampen targeting of caspase-11 to Gram-negative bacterial products
Biorxiv
Eren, E;Planes, R;Bagayoko, S;Bordignon, PJ;
Product: Toxin B from Clostridium difficile
Inflammatory caspase-11 (rodent) and caspases-4 and -5 (human) detect gram-negative bacterial compon....
Characterization of C. difficile strains isolated from companion animals and the associated changes in the host fecal microbiota
Biorxiv
Thanissery, R;McLaren, MR;Rivera, A;Reed, AD;
Product: Toxin A from Clostridium difficile
Background Clostridioides difficile is an enteric pathogen historically known to cause hospital asso....
The Effects of Early-Life Drug and Dietary Interventions on Late-Life Disease Development
Thesis
Mau, T;
Product: Toxin A from Clostridium difficile
Single versus repeated exposure to human polarized intestinal epithelial monolayers for in vitro protein hazard characterization
Food And Chemical Toxicology : An International Journal Published For The British Industrial Biological Research Association
Lanter, BB;Eaton, AD;Roper, JM;Zimmermann, C;Delaney, B;Hurley, BP;
Product: Toxin A from Clostridium difficile
Recent studies suggest human-derived intestinal epithelial cell (IEC) lines cultured as polarized mo....
Methods for Detection of Pyrin Inflammasome Assembly in Macrophages Infected with Yersinia spp
Methods In Molecular Biology
Medici, NP;Bliska, JB;
Product: Toxin B from Clostridium difficile
The Yersinia effector proteins YopE and YopT are important bacterial virulence factors that are secr....
Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells
Nature Microbiology
Tao, L;Tian, S;Zhang, J;Liu, Z;Robinson-McCarthy, L;Miyashita, SI;Breault, DT;Gerhard, R;Oottamasathien, S;Whelan, SPJ;Dong, M;
Product: Anti-Clostridium difficile Toxin A (Chicken lgY)
Clostridium difficile toxin A (TcdA) is a major exotoxin contributing to disruption of the colonic e....
Vaccination against Clostridium difficile using an attenuated Salmonella Typhimurium vector (YS1646) protects mice from lethal challenge
Infection And Immunity
Winter, K;Xing, L;Kassardjian, A;Ward, BJ;
Product: Toxin A from Clostridium difficile
Clostridium difficile disease is mediated primarily by toxins A and B (TcdA and TcdB). The receptor ....
Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control Clostridium difficile colitis
Life Science Alliance
Liu, R;Moriggl, R;Zhang, D;Li, H;Karns, R;Ruan, HB;Niu, H;Mayhew, C;Watson, C;Bangar, H;Cha, SW;Haslam, D;Zhang, T;Gilbert, S;Li, N;Helmrath, M;Wells, J;Denson, L;Han, X;
Product: Toxin A from Clostridium difficile
Clostridium difficile impairs Paneth cells, driving intestinal inflammation that exaggerates colitis....
Outbreak of Murine Infection with Clostridium difficile Associated with the Administration of a Pre- and Perinatal Methyl Donor Diet
mSphere
Mau, T;Eckley, SS;Bergin, IL;Saund, K;Villano, JS;Vendrov, KC;Snitkin, ES;Young, VB;Yung, R;
Product: Toxin A from Clostridium difficile
Between October 2016 and June 2017, a C57BL/6J mouse colony that was undergoing a pre- and perinatal....
Evaluation of a non-canonical Cys40-Cys55 disulfide linkage for stabilization of single-domain antibodies
Protein Science : A Publication Of The Protein Society
Kim, DY;Kandalaft, H;Hussack, G;Raphael, S;Ding, W;Kelly, JF;Henry, KA;Tanha, J;
Product: Toxin A from Clostridium difficile
Incorporation of non-canonical disulfide linkages into single-domain antibodies (sdAbs) has been sho....
Neutralization of Clostridium difficile toxin B with VHH-Fc fusions targeting the delivery and CROPs domains
Plos One
Hussack, G;Ryan, S;van Faassen, H;Rossotti, M;MacKenzie, CR;Tanha, J;
Product: Toxin B from Clostridium difficile
An increasing number of antibody-based therapies are being considered for controlling bacterial infe....
TNF/TNFR axis promotes pyrin inflammasome activation and distinctly modulates pyrin inflammasomopathy
The Journal Of Clinical Investigation
Sharma, D;Malik, A;Guy, C;Vogel, P;Kanneganti, TD;
Product: Toxin B from Clostridium difficile
Pyrin is an inflammasome sensor that promotes caspase-1-mediated pyroptotic cell death and maturatio....
Apoptosis of intestinal epithelial cells restricts Clostridium difficile infection in a model of pseudomembranous colitis
Nature Communications
Saavedra, PHV;Huang, L;Ghazavi, F;Kourula, S;Vanden Berghe, T;Takahashi, N;Vandenabeele, P;Lamkanfi, M;
Product: Toxin B from Clostridium difficile
Clostridium difficile is the leading cause of pseudomembranous colitis in hospitalized patients. C. ....
Monitoring Poly(ADP-ribosyl)glycohydrolase Activity with a Continuous Fluorescent Substrate
Cell Chemical Biology
Drown, BS;Shirai, T;Rack, JGM;Ahel, I;Hergenrother, PJ;
Product: Binary Toxin from Clostridium difficile, A Subunit
The post-translational modification (PTM) and signaling molecule poly(ADP-ribose) (PAR) has an impac....
Aging impairs protective host defenses against Clostridioides (Clostridium) difficile infection in mice by suppressing neutrophil and IL-22 mediated immunity
Anaerobe
Peniche, AG;Spinler, JK;Boonma, P;Savidge, TC;Dann, SM;
Product: Toxin B from Clostridium difficile
Morbidity and mortality associated with Clostridioides (formerly Clostridium) difficile infection (C....
A Small Molecule-Screening Pipeline to Evaluate the Therapeutic Potential of 2-Aminoimidazole Molecules Against Clostridium difficile
Frontiers In Microbiology
Thanissery, R;Zeng, D;Doyle, RG;Theriot, CM;
Product: Toxin A from Clostridium difficile
Antibiotics are considered to be the first line of treatment for mild to moderately severe Clostridi....
A Rapid, Accurate, Single Molecule Counting Method Detects Clostridium difficile Toxin B in Stool Samples
Scientific Reports
Gite, S;Archambault, D;Cappillino, MP;Cunha, D;Dorich, V;Shatova, T;Tempesta, A;Walsh, B;Walsh, JA;Williams, A;Kirby, JE;Bowers, J;Straus, D;
Product: Toxin B from Clostridium difficile
We describe a new rapid and accurate immunoassay-based technology capable of counting single target ....
Extended exposure duration of cultured intestinal epithelial cell monolayers in characterizing hazardous and non-hazardous proteins
Food And Chemical Toxicology : An International Journal Published For The British Industrial Biological Research Association
Zimmermann, C;Eaton, AD;Lanter, BB;Roper, J;Hurley, BP;Delaney, B;
Product: Toxin A from Clostridium difficile
Recent studies suggest that human derived intestinal epithelial cells (IECs) cultured as polarized m....
Clostridium difficile Toxins A and B Decrease Intestinal SLC26A3 Protein Expression
American Journal Of Physiology. Gastrointestinal And Liver Physiology
Coffing, HP;Priyamvada, S;Natarajan Anbazhagan, A;Salibay, C;Engevik, MA;Versalovic, J;Yacyshyn, MB;Yacyshyn, BR;Tyagi, S;Saksena, S;Gill, RK;Alrefai, WA;Dudeja, PK;
Product: Toxin A from Clostridium difficile
Clostridium difficile infection is the primary cause of nosocomial diarrhea in the United States. Wh....
Application of Assisted Design of Antibody and Protein Therapeutics (ADAPT) improves efficacy of a Clostridium difficile toxin A single-domain antibody
Scientific Reports
Sulea, T;Hussack, G;Ryan, S;Tanha, J;Purisima, EO;
Product: Toxin A from Clostridium difficile
Assisted Design of Antibody and Protein Therapeutics (ADAPT) is an affinity maturation platform inte....
Catch-slip behavior observed upon rupturing membrane-cytoskeleton bonds
Biorxiv
Rajasekharan, V;Sreenivasan, eK;Pereira, FA;Farrell, B;
Product: Toxin B from Clostridium difficile
Cells are capable of cytoskeleton remodeling in response to environmental cues at the plasma membran....
Immunization with Recombinant TcdB-Encapsulated Nanocomplex Induces Protection against Clostridium difficile Challenge in a Mouse Model
Frontiers In Microbiology
Liu, YW;Chen, YH;Chen, JW;Tsai, PJ;Huang, IH;
Product: Toxin B from Clostridium difficile
Clostridium difficile is considered to be one of the major cause of infectious diarrhea in healthcar....
Clostridium difficile chimeric toxin receptor binding domain vaccine induced protection against different strains in active and passive challenge models
Vaccine
Tian, JH;Glenn, G;Flyer, D;Zhou, B;Liu, Y;Sullivan, E;Wu, H;Cummings, JF;Elllingsworth, L;Smith, G;
Product: Toxin A from Clostridium difficile
Clostridium difficile is the number one cause of nosocomial antibiotic-associated diarrhea in develo....
Primary human polarized small intestinal epithelial barriers respond differently to a hazardous and an innocuous protein
Food And Chemical Toxicology
Eaton, AD;Zimmermann, C;Delaney, B;Hurley, BP;
Product: Toxin A from Clostridium difficile
An experimental platform employing human derived intestinal epithelial cell (IEC) line monolayers gr....
Secretory immunoglobulin purification from whey by chromatographic techniques
Journal Of Chromatography B
Matlschweiger, A;Engelmaier, H;Himmler, G;Hahn, R;
Product: Toxin B from Clostridium difficile
Secretory immunoglobulins (SIg) are a major fraction of the mucosal immune system and represent pote....
Inhibition of spore germination, growth, and toxin activity of clinically relevant C.difficile strains by gut microbiota derived secondary bile acids
Anaerobe
Thanissery, R;Winston, JA;Theriot, CM;
Product: Toxin A from Clostridium difficile
The changing epidemiology of Clostridium difficile infection over the past decades presents a signif....
Development of a Novel Vaccine Containing Binary Toxin for the Prevention of Clostridium difficile Disease with Enhanced Efficacy against NAP1 Strains
Plos One
Secore, S;Wang, S;Doughtry, J;Xie, J;Miezeiewski, M;Rustandi, RR;Horton, M;Xoconostle, R;Wang, B;Lancaster, C;Kristopeit, A;Wang, SC;Christanti, S;Vitelli, S;Gentile, MP;Goerke, A;Skinner, J;Strable, E;Thiriot, DS;Bodmer, JL;Heinrichs, JH;
Product: Toxin A from Clostridium difficile
Clostridium difficile infections (CDI) are a leading cause of nosocomial diarrhea in the developed w....
Product: Toxin A from Clostridium difficile
Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
Journal Of Visualized Experiments : JoVE
Winston, JA;Thanissery, R;Montgomery, SA;Theriot, CM;
Product: Toxin A from Clostridium difficile
Clostridium difficile is an anaerobic, gram-positive, spore-forming enteric pathogen that is associa....
Polarized monolayer cultures of human intestinal epithelial cell lines exposed to intractable proteins – Invitro hazard identification studies
Food And Chemical Toxicology : An International Journal Published For The British Industrial Biological Research Association
Hurley, BP;Eaton, AD;Zimmermann, C;Delaney, B;
Product: Toxin A from Clostridium difficile
The Yersinia pestis Effector YopM Inhibits Pyrin Inflammasome Activation.
Plos Pathogens
Ratner, D;Orning, MP;Proulx, MK;Wang, D;Gavrilin, MA;Wewers, MD;Alnemri, ES;Johnson, PF;Lee, B;Mecsas, J;Kayagaki, N;Goguen, JD;Lien, E;
Product: Toxin A from Clostridium difficile
Type III secretion systems (T3SS) are central virulence factors for many pathogenic Gram-negative ba....
Frizzled proteins are colonic epithelial receptors for C. difficile toxin B
Nature
Tao, L;Zhang, J;Meraner, P;Tovaglieri, A;Wu, X;Gerhard, R;Zhang, X;Stallcup, WB;Miao, J;He, X;Hurdle, JG;Breault, DT;Brass, AL;Dong, M;
Product: Anti-Clostridium difficile Toxin B (Chicken lgY)
Clostridium difficile toxin B (TcdB) is a critical virulence factor that causes diseases associated ....
Portable, On-Demand Biomolecular Manufacturing
Cell
Pardee, K;Slomovic, S;Nguyen, PQ;Lee, JW;Donghia, N;Burrill, D;Ferrante, T;McSorley, FR;Furuta, Y;Vernet, A;Lewandowski, M;Boddy, CN;Joshi, NS;Collins, JJ;
Product: Toxin A from Clostridium difficile
Synthetic biology uses living cells as molecular foundries for the biosynthesis of drugs, therapeuti....
Recombinant mucin-type fusion proteins with Gal1,3Gal substitution as Clostridium difficile toxin A inhibitors
Infection And Immunity
Cherian, RM;Jin, C;Liu, J;Karlsson, NG;Holgersson, J;
Product: Toxin A from Clostridium difficile
The capability of a recombinant mucin-like fusion protein, P-selectin glycoprotein ligand-1/mouse Ig....
Histidine-Rich Glycoprotein Prevents Septic Lethality through Regulation of Immunothrombosis and Inflammation
EBioMedicine
Wake, H;Mori, S;Liu, K;Morioka, Y;Teshigawara, K;Sakaguchi, M;Kuroda, K;Gao, Y;Takahashi, H;Ohtsuka, A;Yoshino, T;Morimatsu, H;Nishibori, M;
Product: Toxin B from Clostridium difficile
Sepsis is a major cause of death worldwide. We show that a plasma protein histidine-rich glycoprotei....
An experimental platform using human intestinal epithelial cell lines to differentiate between hazardous and non-hazardous proteins
Food And Chemical Toxicology
Hurley, BP;Pirzai, W;Eaton, AD;Harper, M;Roper, J;Zimmermann, C;Ladics, GS;Layton, RJ;Delaney, B;
Product: Toxin B from Clostridium difficile
Human intestinal epithelial cell lines (T84, Caco-2, and HCT-8) grown on permeable Transwell filters....
Immunogenicity and protective efficacy of recombinant Clostridium difficile flagellar protein FliC
Emerging Microbes & Infections
Ghose, C;Eugenis, I;Sun, X;Edwards, AN;McBride, SM;Pride, DT;Kelly, CP;Ho, DD;
Product: Toxin A from Clostridium difficile
Clostridium difficile is a Gram-positive bacillus and is the leading cause of toxin-mediated nosocom....
Ultrasensitive Detection and Quantification of Toxins for Optimized Diagnosis of Clostridium difficile Infection
Journal Of Clinical Microbiolgy
Pollock, NR;
Product: Toxin B from Clostridium difficile
Recently developed ultrasensitive and quantitative methods for detection of Clostridium difficile to....
Neutralization of Clostridium difficile Toxin B Mediated by Engineered Lactobacilli That Produce Single-Domain Antibodies
Infection And Immunity
Andersen, KK;Strokappe, NM;Hultberg, A;Truusalu, K;Smidt, I;Mikelsaar, RH;Mikelsaar, M;Verrips, T;Hammarstrm, L;Marcotte, H;
Product: Toxin B from Clostridium difficile
Clostridium difficile is the primary cause of nosocomial antibiotic-associated diarrhea in the Weste....
Efeito do HA-1077 sobre a migrao e invaso celular em carcinoma epidermoide oral
Thesis
CARBONI, SDESCM;
Product: Toxin A from Clostridium difficile
HA-1077 inhibits cell migration/invasion of oral squamous cell carcinoma.
Anticancer Drugs
Moreira Carboni, Sde S;Rodrigues Lima, NA;Pinheiro, NM;Tavares-Murta, BM;Crema, VO;
Product: Toxin A from Clostridium difficile
Oral squamous cell carcinoma (OSCC) is the most malignant lesion occurring in the head and neck. The....
Fecal Microbiota Transplantation Eliminates Clostridium difficile in a Murine Model of Relapsing Disease
Infection And Immunity
Seekatz, AM;Theriot, CM;Molloy, CT;Wozniak, KL;Bergin, IL;Young, VB;
Product: Toxin B from Clostridium difficile
Recurrent Clostridium difficile infection (CDI) is of particular concern among health care-associate....
The recombinant Lactococcus lactis oral vaccine induces protection against C. difficile spore challenge in a mouse model
Vaccine
Guo, S;Yan, W;McDonough, SP;Lin, N;Wu, KJ;He, H;Xiang, H;Yang, M;Moreira, MA;Chang, YF;
Product: Toxin A from Clostridium difficile
Clostridium difficile infection (CDI) causes nosocomial antibiotic-associated diarrhea and colitis i....
In Vitro Selection of a Single-Stranded DNA Molecular Recognition Element against Clostridium difficile Toxin B and Sensitive Detection in Human Fecal Matter
Journal Of Nucleic Acids
Hong, KL;Maher, E;Williams, RM;Sooter, LJ;
Product: Toxin B from Clostridium difficile
Toxin B is one of the major virulence factors of Clostridium difficile, a bacterium that is responsi....
An in vitro culture model to study the dynamics of colonic microbiota in Syrian golden hamsters and their susceptibility to infection with Clostridium difficile
ISME Journal
Miezeiewski, M;Schnaufer, T;Muravsky, M;Wang, S;Caro-Aguilar, I;Secore, S;Thiriot, DS;Hsu, C;Rogers, I;DeSantis, T;Kuczynski, J;Probst, AJ;Chehoud, C;Steger, R;Warrington, J;Bodmer, JL;Heinrichs, JH;
Product: Toxin A from Clostridium difficile
Clostridium difficile infections (CDI) are caused by colonization and growth of toxigenic strains of....
Broad coverage of genetically diverse strains of Clostridium difficile by actoxumab and bezlotoxumab predicted by in vitro neutralization and epitope modeling
Antimicrobial Agents And Chemotherapy
Hernandez, LD;Racine, F;Xiao, L;DiNunzio, E;Hairston, N;Sheth, PR;Murgolo, NJ;Therien, AG;
Product: Toxin A from Clostridium difficile
Clostridium difficile infections (CDIs) are the leading cause of hospital-acquired infectious diarrh....
Persistence and toxin production by Clostridium difficile within human intestinal organoids result in disruption of epithelial paracellular barrier function
Infection And Immunity
Leslie, JL;Huang, S;Opp, JS;Nagy, MS;Kobayashi, M;Young, VB;Spence, JR;
Product: Toxin A from Clostridium difficile
Clostridium difficile is the leading cause of infectious nosocomial diarrhea. The pathogenesis of C.....
Clostridium difficile-induced colitis in mice is independent of leukotrienes
Anaerobe
Trindade, BC;Theriot, CM;Leslie, JL;Carlson, PE;Bergin, IL;Peters-Golden, M;Young, VB;Aronoff, DM;
Product: Toxin B from Clostridium difficile
Clostridium difficile is the major cause of antibiotic-associated diarrhea and pseudomembranous coli....
Multivalent adhesion molecule 7 clusters act as signaling platform for host cellular GTPase activation and facilitate epithelial barrier dysfunction
PLoS Pathogens
Lim, J;Stones, DH;Hawley, CA;Watson, CA;Krachler, AM;
Product: Toxin B from Clostridium difficile
Vibrio parahaemolyticus is an emerging bacterial pathogen which colonizes the gastrointestinal tract....
Equine hyperimmune serum protects mice against Clostridium difficile spore challenge
Journal Of Veterinary Science
Yan, W;Shin, KS;Wang, SJ;Xiang, H;Divers, T;McDonough, S;Bowman, J;Rowlands, A;Akey, B;Mohamed, H;Chang, YF;
Product: Toxin A from Clostridium difficile
Clostridium (C.) difficile is a common cause of nosocomial diarrhea in horses. Vancomycin and metron....
Development of a recombinant toxin fragment vaccine for Clostridium difficile infection
Vaccine
Karczewski, J;Zorman, J;Wang, S;Miezeiewski, M;Xie, J;Soring, K;Petrescu, I;Rogers, I;Thiriot, DS;Cook, JC;Chamberlin, M;Xoconostle, RF;Nahas, DD;Joyce, JG;Bodmer, JL;Heinrichs, JH;Secore, S;
Product: Toxin A from Clostridium difficile
Clostridium difficile infection (CDI) is the major cause of antibiotic-associated diarrhea and pseud....
Rho GTPases control ciliary epithelium cells proliferation and progenitor profile induction in vivo
Investigative Ophthalmology And Visual Science
Del Debbio, CB;Santos, MF;Yan, CY;Ahmad, I;Hamassaki, DE;
Product: Toxin A from Clostridium difficile
Rho GTPases play a central role in actin-based cytoskeleton reorganization and regulate multiple sig....
Real-time cellular analysis coupled with a specimen enrichment accurately detects and quantifies Clostridium difficile toxins in stool
Journal Of Clinical Microbiolgy
Huang, B;Jin, D;Zhang, J;Sun, JY;Wang, X;Stiles, J;Xu, X;Kamboj, M;Babady, NE;Tang, YW;
Product: Toxin B from Clostridium difficile
We describe here the use of an immunomagnetic separation enrichment process coupled with a modified ....
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