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Neurotrophic factors loaded TGN-modified chitosan nanoparticles ameliorate symptoms of MS through GATA3/FOXP3 and targeting Th1/2cells pathways

Khodakarimi, S;Zarebkohan, A;Mohaddes, G;Shiri-Shahsavari, M;Omrani, M;Sepasi, T;Beyrampour-Basmenj, H;Ebrahimi-Kalan, A;

Two most promising treatment strategies for multiple sclerosis (MS) are the administration of mesenchymal stem cells (MSCs) and targeted delivery of cerebrolysin. Comparing these treatment plans as a source of neurotrophic factors (NTFs) can inform future MS treatment guidelines. This study was carried out on the experimental autoimmune encephalomyelitis as an animal model of MS through NTFs-loaded TGN-modified chitosan nanoparticles (NTFs@TCN) and MSCs administration. The clinical scores considerations and evaluation of biological samples were shown significant improvement in locomotion activity accompanied by a decrease in lymphocyte infiltration on spinal cord tissues in the NTFs@TCN received group. These alterations may be modulated through GATA3/FOXP3 and targeting Th1/2 cells pathways. Our data shows that the targeted drug delivery strategies and high accessibility to the central nervous system may be a suitable option in the management of MS compared to cell therapy and pure NTFs administration.