Pertussis Toxin Mutant

List Labs sells a genetically inactivated form of pertussis toxin, Pertussis Toxin Mutant (PT_MUT). This protein may be used as an antigen and as a carrier protein for other antigens.

Pertussis mutant protein is isolated from the TY-178 strain of Bordetella bronchiseptica.  Site-directed mutagenesis was used to replace amino acid residues in the enzyme active site. Although diminished, this mutant retains some of the activity of the native toxin.

• Product #184 Pertussis toxin mutant (R9K, E129A) is provided lyophilized in phosphate buffer and an accompanying C of A describes the CHO cell toxicity.