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Recirculating regulatory Tcells mediate thymic regeneration through amphiregulin following damage
Immunity
Lemarquis, AL;Kousa, AI;Argyropoulos, KV;Jahn, L;Gipson, B;Pierce, J;Serrano-Marin, L;Victor, K;Kanno, Y;Girotra, NN;Andrlova, H;Tsai, J;Velardi, E;Sharma, R;Grassmann, S;Ekwall, O;Goldstone, AB;Dudakov, JA;DeWolf, S;van den Brink, MRM;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Thymic injury associated with disease or cancer treatment reduces T cell production and makes patien....
Galectin-1-Induced Tumor Associated Macrophages Repress Antitumor Immunity in Hepatocellular Carcinoma Through Recruitment of Tregs
Advanced Science
Yu, X;Qian, J;Ding, L;Pan, C;Liu, X;Wu, Q;Wang, S;Liu, J;Shang, M;Su, R;Guo, D;Xie, H;Yin, S;Zhou, L;Zheng, S;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Tumor-associated macrophages (TAMs) are commonly considered accomplices in tumorigenesis and tumor d....
A CD26+ tendon stem progenitor cell population contributes to tendon repair and heterotopic ossification
Nature Communications
Chen, S;Lin, Y;Yang, H;Li, Z;Li, S;Chen, D;Hao, W;Zhang, S;Chao, H;Zhang, J;Wang, J;Li, Z;Li, X;Zhan, Z;Liu, H;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Inadequate tendon healing and heterotopic bone formation result in substantial pain and disability, ....
The spinal premotor network driving scratching flexor and extensor alternation
Biorxiv : The Preprint Server For Biology
Yao, M;Nagamori, A;Azim, E;Sharpee, T;Goulding, M;Golomb, D;Gatto, G;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Rhythmic motor behaviors are generated by neural networks termed central pattern generators (CPGs). ....
Tumor initiating cells escape tumor immunity via CCL8 from tumor-associated macrophages in mice
The Journal Of Clinical Investigation
Chen, S;Huang, CS;Li, K;Cheng, M;Zhang, C;Xiong, J;Tian, G;Zhou, R;Ling, R;Wang, X;Xiong, G;Zhang, Z;Ma, J;Zhu, Y;Zhou, B;Peng, L;Peng, Z;Li, H;Chen, D;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Tumor-initiating cells (TICs) play a key role in cancer progression and immune escape. However, how ....
Sensory innervation in the prostate and a role for calcitonin gene-related peptide in prostatic epithelial proliferation
Frontiers In Molecular Neuroscience
Xia, H;Jerde, TJ;Fehrenbacher, JC;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
The prostate is densely innervated like many visceral organs and glands. However, studies to date ha....
Dendritic cells accelerate CAR T cells in irradiated tumors through chimeric synapses
Biorxiv
Navarre, S;Ishibashi, M;Nair, A;Reyes-Torres, I;Belabed, M;Halasz, L;Park, M;Mattiuz, R;Ounadjela, M;Gunset, G;Mansilla-Soto, J;Feucht, J;Cabriolu, A;Berichel, J;Eyquem, J;Brown, B;Merad, M;Sadelain, M;Ahmed, J;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
The persistence of adoptively transferred T cells is vital for anti-tumor efficacy. Chimeric antigen....
Fibroblastic reticular cells generate protective intratumoral Tcell environments in lung cancer
Cell
Onder, L;Papadopoulou, C;Lütge, A;Cheng, HW;Lütge, M;Perez-Shibayama, C;Gil-Cruz, C;De Martin, A;Kurz, L;Cadosch, N;Pikor, NB;Rodriguez, R;Born, D;Jochum, W;Leskow, P;Dutly, A;Robinson, MD;Ludewig, B;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Stringent control of T cell activity in the tumor microenvironment is essential for the generation o....
JAK/STAT signaling maintains an intermediate cell population during prostate basal cell fate determination
Nature Genetics
Guo, W;Zhang, X;Li, L;Shao, P;Liang, C;Zhang, H;Liu, K;Wang, S;Peng, Y;Luo, J;Ju, Y;De Marzo, AM;Yu, C;Chen, L;Zhou, B;Gao, D;
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Unipotent basal and luminal stem cells maintain prostate homeostasis, with an intermediate cell popu....
TIMD4hiMHC?hi Macrophages Preserve Heart Function Through Retnla
Jacc: Basic To Translational Science
Zhang, D;Wang, X;Zhu, L;Chen, Y;Yang, C;Zhong, Z;Kong, X;Nan, J;Wang, C;Hu, H;Chen, J;Shi, P;Hu, X;Zhu, W;Wang, J;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Genetic fate mapping confirmed the existence of the TIMD4hiMHC?hi macrophage subset and showed that ....
Alternations in inflammatory macrophage niche drive phenotypic and functional plasticity of Kupffer cells
Nature Communications
Huang, HY;Chen, YZ;Zhao, C;Zheng, XN;Yu, K;Yue, JX;Ju, HQ;Shi, YX;Tian, L;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Inflammatory signals lead to recruitment of circulating monocytes and induce their differentiation i....
An IFN-STAT1-CYBB Axis Defines Protective Plasmacytoid DC to Neutrophil Crosstalk During Aspergillus fumigatus Infection
Biorxiv : The Preprint Server For Biology
Guo, Y;Aufiero, MA;Mills, KAM;Grassmann, SA;Kim, H;Zumbo, P;Gjonbalaj, M;Billips, A;Mar, KB;Yu, Y;Betel, D;Sun, JC;Hohl, TM;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Aspergillus fumigatus is the most common cause of invasive aspergillosis (IA), a devastating infecti....
Innate cells and STAT1-dependent signals orchestrate vaccine-induced protection against invasive Cryptococcus infection
Mbio
Wang, K;Espinosa, V;Wang, Y;Lemenze, A;Kumamoto, Y;Xue, C;Rivera, A;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
FFungal pathogens are underappreciated causes of significant morbidity and mortality worldwide. In p....
Lung-resident alveolar macrophages regulate the timing of breast cancer metastasis
Cell
Dalla, E;Papanicolaou, M;Park, MD;Barth, N;Hou, R;Segura-Villalobos, D;Valencia Salazar, L;Sun, D;Forrest, ARR;Casanova-Acebes, M;Entenberg, D;Merad, M;Aguirre-Ghiso, JA;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Breast disseminated cancer cells (DCCs) can remain dormant in the lungs for extended periods, but th....
Ccl2-Induced Regulatory T Cells Balance Inflammation Through Macrophage Polarization During Liver Reconstitution
Advanced Science
Wang, R;Liang, Q;Zhang, Q;Zhao, S;Lin, Y;Liu, B;Ma, Y;Mai, X;Fu, Q;Bao, X;Wang, N;Chen, B;Yan, P;Zhu, Y;Wang, K;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Inflammation is highlighted as an initial factor that helps orchestrate liver reconstitution. Howeve....
Endogenous opioid signalling regulates spinal ependymal cell proliferation
Nature
Yue, WWS;Touhara, KK;Toma, K;Duan, X;Julius, D;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
After injury, mammalian spinal cords develop scars to confine the lesion and prevent further damage.....
Disruption of perinatal myeloid niches impacts the aging clock of pancreatic β cells
Iscience
O'Sell, J;Cirulli, V;Pardike, S;Aare-Bentsen, M;Sdek, P;Anderson, J;Hailey, D;Regier, M;Gharib, S;Crisa, L;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Perinatal expansion of pancreatic b cells is critical to metabolic adaptation. Yet, mechanisms surve....
Acidity induces durable enhancement of Treg cell suppressive functions for tumor immune evasion
Molecular Immunology
Mani, NL;Weinberg, SE;Chaudhuri, S;Montauti, E;Tang, A;Iyer, R;Fang, D;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
The microenvironment within solid tumors often becomes acidic due to various factors associated with....
Splenic CD169 + Tim4 + Marginal Metallophilic Macrophages Are Essential for Wound Healing After Myocardial Infarction
Medrxiv : The Preprint Server For Health Sciences
Ismahil, MA;Zhou, G;Gao, M;Bansal, SS;Patel, B;Limdi, N;Xie, M;Antipenko, S;Rokosh, G;Hamid, T;Prabhu, SD;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Fidelity of wound healing after myocardial infarction (MI) is an important determinant of subsequent....
A Live Tracker of Dormant Disseminated Tumor Cells
Methods In Molecular Biology (Clifton, N.J.)
Landum, F;Correia, AL;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
The high prevalence of dormant disseminated tumor cells (DTCs) persisting systemically in patients w....
CD11c-expressing microglia are transient, driven by interactions with apoptotic cells
Biorxiv
Ghena, N;Anderson, S;Roberts, J;Irvin, E;Schwakopf, J;Bosco, A;Vetter, M;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Microglia, the parenchymal macrophage of the central nervous system serve crucial remodeling functio....
Identification of ibuprofen targeting CXCR family members to alleviate metabolic disturbance in lipodystrophy based on bioinformatics and in vivo experimental verification
Frontiers In Endocrinology
Cao, Z;Zhao, Y;Liu, R;Yan, X;Wang, J;Chen, N;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Lipodystrophy is a rare disease that is poorly diagnosed due to its low prevalence and frequent phen....
FOXP3+ Regulatory T Cells Require TBET to Regulate Activated CD8+ T Cells During Recovery from Influenza Infection
Biorxiv : The Preprint Server For Biology
Mambetsariev, N;Acosta, MAT;Liu, Q;Flores, CPR;Joudi, AM;Helmin, KA;Gurkan, JK;Steinert, EM;Morales-Nebreda, L;Singer, BD;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
FOXP3+ regulatory T (Treg) cells are necessary to coordinate resolution of lung inflammation and a r....
AAV-mediated Gene Cocktails Enhance Supporting Cell Reprogramming and Hair Cell Regeneration
Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
Zhang, L;Chen, X;Wang, X;Zhou, Y;Fang, Y;Gu, X;Zhang, Z;Sun, Q;Li, N;Xu, L;Tan, F;Chai, R;Qi, J;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Mammalian cochlear hair cells (HCs) are essential for hearing, and damage to HCs results in severe h....
FGD5 in basal cells induces CXCL14 secretion that initiates a feedback loop to promote murine mammary epithelial growth and differentiation
Developmental Cell
Zhang, T;Zhao, C;Li, Y;Wu, J;Wang, F;Yu, J;Wang, Z;Gao, Y;Zhao, L;Liu, Y;Yan, Y;Li, X;Gao, H;Hu, Z;Cui, B;Li, K;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
The interactions of environmental compartments with epithelial cells are essential for mammary gland....
Foxp3+ Treg control allergic skin inflammation by restricting IFN-?-driven neutrophilic infiltration and NETosis
Journal Of Dermatological Science
Tong, X;Kim, S;Che, L;Park, J;Lee, J;Kim, T;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Background Atopic dermatitis (AD), a chronic inflammatory skin disease with T cell activation as a k....
Availability of an inflammatory macrophage niche drives phenotypic and functional alterations in Kupffer cells
Biorxiv
Huang, H;Chen, Y;Zheng, X;Yue, J;Ju, H;Shi, Y;Tian, L;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Inflammatory signals lead to recruitment of circulating monocytes and induce their differentiation i....
Tolerogenic dendritic cell-mediated regulatory T cell differentiation by Chinese herbal formulation attenuates colitis progression
Journal Of Advanced Research
Huang, C;Lyu, C;Mok, HL;Xu, Y;Cheng, KW;Zhang, C;Hu, D;Zhu, L;Lin, C;Chen, X;Tan, HY;Bian, Z;
Product: Diphtheria Toxin CRM197, Mutant
Ulcerative colitis (UC) is a chronic inflammatory disease characterized by loss of immune tolerance ....
Growth hormone promotes myelin repair after chronic hypoxia via triggering pericyte-dependent angiogenesis
Neuron
Ren, SY;Xia, Y;Yu, B;Lei, QJ;Hou, PF;Guo, S;Wu, SL;Liu, W;Yang, SF;Jiang, YB;Chen, JF;Shen, KF;Zhang, CQ;Wang, F;Yan, M;Ren, H;Yang, N;Zhang, J;Zhang, K;Lin, S;Li, T;Yang, QW;Xiao, L;Hu, ZX;Mei, F;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
White matter injury (WMI) causes oligodendrocyte precursor cell (OPC) differentiation arrest and fun....
Transient Seizure Clusters and Epileptiform Activity Following Widespread Bilateral Hippocampal Interneuron Ablation
Eneuro
Dusing, MR;LaSarge, CL;Drake, AW;Westerkamp, GC;McCoy, C;Hetzer, SM;Kraus, KL;Pedapati, EV;Danzer, SC;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Interneuron loss is a prominent feature of temporal lobe epilepsy in both animals and humans and is ....
Sensorineural correlates of failed functional recovery after natural regeneration of vestibular hair cells in adult mice
Frontiers In Neurology
Jáuregui, EJ;Scheinman, KL;Bibriesca Mejia, IK;Pruett, L;Zaini, H;Finkbeiner, C;Phillips, JA;Gantz, JA;Nguyen, TB;Phillips, JO;Stone, JS;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Vestibular hair cells (HCs) are mechanoreceptors that sense head motions by modulating the firing ra....
Methods employed in a 2021 population-based serosurvey in Somalia
Gates Open Research
Hossain, M;Ali, A;Clary, C;Cooley, G;Farid, M;Gerber, S;Hoff, N;Ibrahim, A;Mainou, B;Malik, D;Martin, H;Mdodo, R;Mengistu, K;Obsie, A;Reynolds, Z;Rhoda, D;Shube, M;Sinai, C;Trimner, M;Webeck, J;
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This paper describes the design and methods of a serosurvey conducted in Somalia in 2021. The study ....
A parabrachial hub for the prioritization of survival behavior
Biorxiv
Goldstein, N;Maes, A;Allen, H;Nelson, T;Kruger, K;Kindel, M;Smith, N;Carty, J;Villari, R;Cho, E;Marble, E;Khanna, R;Taylor, B;Kennedy, A;Betley, J;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Long-term sustained pain in the absence of acute physical injury is a prominent feature of chronic p....
RORα is required for expansion and memory maintenance of ILC1s via a lymph node-liver axis
Cell Reports
Cheng, M;Li, J;Song, J;Song, H;Chen, Y;Tang, H;Wei, H;Sun, R;Tian, Z;Wang, X;Peng, H;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Type 1 innate lymphoid cells (ILC1s) possess adaptive immune features, which confer antigen-specific....
Divergent Sensory Pathways of Sneezing and Coughing
SSRN
Jiang, H;Cui, H;Chen, M;Li, F;Shen, X;Guo, C;Hoekel, G;Zhu, Y;Han, L;Wu, K;Holtzman, M;Liu, Q;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Sneezing and coughing are primary symptoms of many respiratory viral infections and allergies. It is....
Nestin-expressing cells are mitotically active in the mammalian inner ear
Hearing Research
Kalmanson, O;Takeda, H;Anderson, SR;Dondzillo, A;Gubbels, S;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Nestin expression is associated with pluripotency. Growing evidence suggests nestin is involved in h....
Targeting resident astrocytes attenuates neuropathic pain after spinal cord injury
Biorxiv
Zhao, Q;Zhu, Y;Ren, Y;Zhao, L;Zhao, J;Yin, S;Ni, H;Zhu, R;Cheng, L;Xie, N;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Astrocytes derive from different lineages and play a critical role in neuropathic pain after spinal ....
The choroid plexus maintains ventricle volume and adult subventricular zone neuroblast pool, which facilitates post-stroke neurogenesis
Biorxiv
Taranov, A;Bedolla, A;Iwasawa, E;Brown, F;Baumgartner, S;Fugate, E;Levoy, J;Crone, S;Goto, J;Luo, Y;
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The brain’s neuroreparative capacity after injuries such as ischemic stroke is contained in the brai....
Paracrine signalling by pancreatic ? cells determines the glycaemic set point in mice
Nature Metabolism
Huang, J;Pourhosseinzadeh, M;Lee, S;Krämer, N;Guillen, J;Cinque, N;Aniceto, P;Momen, A;Koike, S;Huising, M;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Renal macrophages monitor and remove particles from urine to prevent tubule obstruction
Immunity
He, J;Cao, Y;Zhu, Q;Wang, X;Cheng, G;Wang, Q;He, R;Lu, H;Weng, Y;Mao, G;Bao, Y;Wang, J;Liu, X;Han, F;Shi, P;Shen, XZ;
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When the filtrate of the glomerulus flows through the renal tubular system, various microscopic sedi....
Adipose cDC1s contribute to obesity-associated inflammation through STING-dependent IL-12 production
Nature Metabolism
Hildreth, AD;Padilla, ET;Gupta, M;Wong, YY;Sun, R;Legala, AR;O'Sullivan, TE;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Obesity is associated with chronic low-grade white adipose tissue (WAT) inflammation that can contri....
Ly6C-high monocytes alleviate brain injury in experimental subarachnoid hemorrhage in mice
Journal Of Neuroinflammation
Chen, H;Xu, C;Zeng, H;Zhang, Z;Wang, N;Guo, Y;Zheng, Y;Xia, S;Zhou, H;Yu, X;Fu, X;Tang, T;Wu, X;Chen, Z;Peng, Y;Cai, J;Li, J;Yan, F;Gu, C;Chen, G;Chen, J;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Background Subarachnoid hemorrhage (SAH) is an uncommon type of potentially fatal stroke. The pathop....
Critical role of CD206+ macrophages in organizing anti-tumor immunity
Biorxiv
Ray, A;Hu, KH;Kersten, K;Kuhn, NF;Samad, B;Combes, AJ;Krummel, MF;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Tumor-associated macrophages (TAMs) are frequently and simplistically categorized as immunosuppressi....
Rapid activation of IL-2 receptor signaling by CD301b+DC-derived IL-2 dictates the outcome of helper T cell differentiation
Biorxiv
Tatsumi, N;El-Fenej, J;Davila-Pagan, A;Kumamoto, Y;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Effector T helper (Th) cell differentiation is fundamental to functional adaptive immunity. Differen....
Endogenous Opioid Signaling Regulates Proliferation of Spinal Cord Ependymal Cells
Biorxiv
Yue, W;Touhara, K;Toma, K;Duan, X;Julius, D;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
After injury, mammalian spinal cords develop scars to seal off the damaged area and prevent further ....
Dysregulation of gd intraepithelial lymphocytes precedes Crohn’s disease-like ileitis
Biorxiv
Xu, W;Golovchenko, N;Fong, A;Achi, S;Bucar, E;Vidmar, K;Zhang, L;Frey, M;Prinz, I;Pizarro, T;Kollias, G;Edelblum, K;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IELs) provide immunosurveillance o....
Interactions between B cells and T follicular regulatory cells enhance susceptibility to Brucella infection independent of the anti-Brucella humoral response
Plos Pathogens
Dadelahi, AS;Abushahba, MFN;Ponzilacqua-Silva, B;Chambers, CA;Moley, CR;Lacey, CA;Dent, AL;Skyberg, JA;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Brucellosis, caused by facultative, intracellular Brucella spp., often results in chronic and/or lif....
Heterologous Expression of Recombinant Proteins and Their Derivatives Used as Carriers for Conjugate Vaccines
Biochemistry (Moscow)
Khodak, YA;
Product: Diphtheria Toxin CRM197, Mutant
Carrier proteins that provide an effective and long-term immune response to weak antigens has become....
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Anorexia nervosa (AN) is a psychiatric disorder mainly characterized by extreme hypophagia, severe b....
SLC38A5 aggravates DC-mediated psoriasiform skin inflammation via potentiating lysosomal acidification
Cell Reports
Zhu, L;Xia, X;Li, G;Zhu, C;Li, Q;Wang, B;Shi, NX;Lei, Z;Yang, S;Zhang, Z;Li, H;Tan, J;Liu, Z;Wen, Q;Zhong, H;Lin, XJ;Sun, G;Bao, X;Wang, Q;Deng, L;Bin, L;Cao, G;Yin, Z;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Amino acid (aa) metabolism is closely correlated with the pathogenesis of psoriasis; however, detail....
Intranasal delivery of an adenovirus-vector vaccine co-expressing a modified spike protein and a genetic adjuvant confers lasting mucosal immunity against SARS-CoV-2
Antiviral Research
Jung, HE;Ku, KB;Kang, BH;Park, JH;Kim, HC;Kim, KD;Lee, HK;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
The ongoing COVID-19 pandemic caused by SARS-CoV-2 infection has threatened global health. Since the....
Tissue-Resident Alveolar Macrophages Control the Timing of Breast Cancer Metastatic Outgrowth in the Lung
SSRN
Dalla, E;Papanicolaou, M;Park, M;Hou, R;Sun, D;Forrest, A;Barth, N;Casanova-Acebes, M;Entenberg, D;Merad, M;Aguirre-Ghiso, J;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Breast disseminated cancer cells (DCCs) can lodge in the lungs early during cancer evolution and per....
Conserved transcriptional connectivity of regulatory T cells in the tumor microenvironment informs new combination cancer therapy strategies
Nature Immunology
Glasner, A;Rose, SA;Sharma, R;Gudjonson, H;Chu, T;Green, JA;Rampersaud, S;Valdez, IK;Andretta, ES;Dhillon, BS;Schizas, M;Dikiy, S;Mendoza, A;Hu, W;Wang, ZM;Chaudhary, O;Xu, T;Mazutis, L;Rizzuto, G;Quintanal-Villalonga, A;Manoj, P;de Stanchina, E;Rudin, CM;Pe'er, D;Rudensky, AY;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
While regulatory T (Treg) cells are traditionally viewed as professional suppressors of antigen pres....
Cell Specificity of Manganese-enhanced MRI Signal in the Cerebellum
Neuroimage
Rallapalli, H;Bayin, NS;Goldman, H;Maric, D;Nieman, BJ;Koretsky, AP;Joyner, AL;Turnbull, DH;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Magnetic Resonance Imaging (MRI) resolution continues to improve, making it important to understand ....
Peripheral Fragile X messenger ribonucleoprotein is required for the timely closure of a critical period for neuronal susceptibility in the ventral cochlear nucleus
Frontiers In Cellular Neuroscience
Yu, X;Wang, Y;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Alterations in neuronal plasticity and critical periods are common across neurodevelopmental disease....
Microglia modulate general anesthesia through P2Y12 receptor
Current Biology
Cao, K;Qiu, L;Lu, X;Wu, W;Hu, Y;Cui, Z;Jiang, C;Luo, Y;Shao, Y;Xi, W;Zeng, LH;Xu, H;Ma, H;Zhang, Z;Peng, J;Duan, S;Gao, Z;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
General anesthesia (GA) is an unconscious state produced by anesthetic drugs, which act on neurons t....
Age-associated B cells are heterogeneous and dynamic drivers of autoimmunity in mice
The Journal Of Experimental Medicine
Nickerson, KM;Smita, S;Hoehn, KB;Marinov, AD;Thomas, KB;Kos, JT;Yang, Y;Bastacky, SI;Watson, CT;Kleinstein, SH;Shlomchik, MJ;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Age-associated B cells (ABCs) are formed under inflammatory conditions and are considered a type of ....
A spinal synergy of excitatory and inhibitory neurons coordinates ipsilateral body movements
Biorxiv : The Preprint Server For Biology
Hayashi, M;Gullo, M;Senturk, G;Di Costanzo, S;Nagasaki, SC;Kageyama, R;Imayoshi, I;Goulding, M;Pfaff, SL;Gatto, G;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Innate and goal-directed movements require a high-degree of trunk and appendicular muscle coordinati....
Microglial IL-1RA ameliorates brain injury after ischemic stroke by inhibiting astrocytic CXCL1-mediated neutrophil recruitment and microvessel occlusion
Glia
Huang, X;Guo, M;Zhang, Y;Xie, J;Huang, R;Zuo, Z;Saw, PE;Cao, M;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Acute ischemic stroke (AIS), one of the leading causes of mortality worldwide, is characterized by a....
MafB-restricted local monocyte proliferation precedes lung interstitial macrophage differentiation
Nature Immunology
Vanneste, D;Bai, Q;Hasan, S;Peng, W;Pirottin, D;Schyns, J;Maréchal, P;Ruscitti, C;Meunier, M;Liu, Z;Legrand, C;Fievez, L;Ginhoux, F;Radermecker, C;Bureau, F;Marichal, T;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Resident tissue macrophages (RTMs) are differentiated immune cells that populate distinct niches and....
Tetanus and Diphtheria Seroprotection among Children Younger Than 15 Years in Nigeria, 2018: Who Are the Unprotected Children?
Vaccines
Tohme, RA;Scobie, HM;Okunromade, O;Olaleye, T;Shuaib, F;Jegede, T;Yahaya, R;Nnaemeka, N;Lawal, B;Egwuenu, A;Parameswaran, N;Cooley, G;An, Q;Coughlin, M;Okposen, BB;Adetifa, I;Bolu, O;Ihekweazu, C;
Product: Diphtheria Toxoid, from Corynebacterium diphtheriae
Serological surveys provide an objective biological measure of population immunity, and tetanus sero....
CD115- monocytic myeloid-derived suppressor cells are precursors of OLFM4high polymorphonuclear myeloid-derived suppressor cells
Communications Biology
Zou, Y;Kamada, N;Seong, SY;Seo, SU;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Myeloid-derived suppressor cells (MDSCs) consist of monocytic (M-) MDSCs and polymorphonuclear (PMN-....
Type 2 Dendritic Cells Orchestrate a Local Immune Circuit to Confer Antimetastatic Immunity
Journal Of Immunology
Weizman, OE;Luyten, S;Krykbaeva, I;Song, E;Mao, T;Bosenberg, M;Iwasaki, A;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
The progression of transformed primary tumors to metastatic colonization is a lethal determinant of ....
Sterile liver injury induces a protective tissue-resident cDC1-ILC1 circuit through cDC1-intrinsic cGAS-STING-dependent IL-12 production
Cell Reports
Hildreth, AD;Padilla, ET;Tafti, RY;Legala, AR;O'Sullivan, TE;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Tissue-resident immune cells are critical to the initiation and potentiation of inflammation. Howeve....
Regulatory T cells alleviate myelin loss and cognitive dysfunction by regulating neuroinflammation and microglial pyroptosis via TLR4/MyD88/NF-?B pathway in LPC-induced demyelination
Journal Of Neuroinflammation
Wang, Y;Sadike, D;Huang, B;Li, P;Wu, Q;Jiang, N;Fang, Y;Song, G;Xu, L;Wang, W;Xie, M;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Demyelination occurs in multiple central nervous system (CNS) disorders and is tightly associated wi....
Lung injury induces a polarized immune response by self antigen-specific Foxp3 + regulatory T cells
Biorxiv : The Preprint Server For Biology
Shin, DS;Ratnapriya, S;Cashin, CN;Kuhn, LF;Rahimi, RA;Anthony, RM;Moon, JJ;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Self antigen-specific T cells are prevalent in the mature adaptive immune system, but are regulated ....
Integrin ?v?3 Limits Toll-Like Receptor Type I Interferon Production by Plasmacytoid Dendritic Cells and Restricts Autoimmunity
Thesis
Lorant, AK;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Plasmacytoid dendritic cells (pDCs) are strongly implicated as a major source of type I interferon (....
Sox2 is required in supporting cells for normal levels of vestibular hair cell regeneration in adult mice
Hearing Research
Berlingeri, ANC;Pujol, R;Cox, BC;Stone, JS;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Sox2 is a transcription factor that is necessary in the mammalian inner ear for development of senso....
Local IL-23 is required for proliferation and retention of skin-resident memory TH17 cells
Science Immunology
Whitley, SK;Li, M;Kashem, SW;Hirai, T;Igyártó, BZ;Knizner, K;Ho, J;Ferris, LK;Weaver, CT;Cua, DJ;McGeachy, MJ;Kaplan, DH;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
The cytokine interleukin-23 (IL-23) is critical for development and maintenance of autoimmune inflam....
Depletion of regulatory T cells exacerbates inflammatory responses after chronic cerebral hypoperfusion in mice
Molecular and Cellular Neurosciences
Wang, Y;Wu, Q;Fang, Y;Song, G;Xu, L;Wang, W;Pan, D;Xie, M;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Vascular cognitive impairment is the second most common cause of dementia which can be induced by ch....
Blood monocyte-derived CD169+ macrophages contribute to antitumor immunity against glioblastoma
Nature Communications
Kim, HJ;Park, JH;Kim, HC;Kim, CW;Kang, I;Lee, HK;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Infiltrating tumor-associated macrophages (TAM) are known to impede immunotherapy against glioblasto....
Microglia-derived PDGFB promotes neuronal potassium currents to suppress basal sympathetic tonicity and limit hypertension
Immunity
Bi, Q;Wang, C;Cheng, G;Chen, N;Wei, B;Liu, X;Li, L;Lu, C;He, J;Weng, Y;Yin, C;Lin, Y;Wan, S;Zhao, L;Xu, J;Wang, Y;Gu, Y;Shen, XZ;Shi, P;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Although many studies have addressed the regulatory circuits affecting neuronal activities, local no....
Active Circulation of Corynebacterium ulcerans among Nonhuman Primates
Microbiology Spectrum
Thomas, A;Slifka, AM;Hendrickson, SM;Amanna, IJ;Slifka, MK;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Diphtheria is rare in the United States. and many industrialized nations due to development of an ef....
Genetic tracing reveals transcription factor Foxp3-dependent and Foxp3-independent functionality of peripherally induced Treg cells
Immunity
van der Veeken, J;Campbell, C;Pritykin, Y;Schizas, M;Verter, J;Hu, W;Wang, ZM;Matheis, F;Mucida, D;Charbonnier, LM;Chatila, TA;Rudensky, AY;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Regulatory T (Treg) cells expressing the transcription factor Foxp3 are an essential suppressive T c....
Visualizing Spatial and Stoichiometric Barriers to Bispecific T-Cell Engager Efficacy
Cancer Immunology Research
You, R;Artichoker, J;Ray, A;Gonzalez Velozo, H;Rock, DA;Conner, KP;Krummel, MF;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Bispecific T-cell engager (BiTE) molecules are biologic T cell-directing immunotherapies. Blinatumom....
A vaccine targeting resistant tumours by dual T cell plus NK cell attack
Nature
Badrinath, S;Dellacherie, MO;Li, A;Zheng, S;Zhang, X;Sobral, M;Pyrdol, JW;Smith, KL;Lu, Y;Haag, S;Ijaz, H;Connor-Stroud, F;Kaisho, T;Dranoff, G;Yuan, GC;Mooney, DJ;Wucherpfennig, KW;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Most cancer vaccines target peptide antigens, necessitating personalization owing to the vast inter-....
AGBE: a dual deaminase-mediated base editor by fusing CGBE with ABE for creating a saturated mutant population with multiple editing patterns
Nucleic Acids Research
Liang, Y;Xie, J;Zhang, Q;Wang, X;Gou, S;Lin, L;Chen, T;Ge, W;Zhuang, Z;Lian, M;Chen, F;Li, N;Ouyang, Z;Lai, C;Liu, X;Li, L;Ye, Y;Wu, H;Wang, K;Lai, L;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Establishing saturated mutagenesis in a specific gene through gene editing is an efficient approach ....
Polarized macrophages promote gestational beta cell growth through extracellular signal-regulated kinase 5 signalling
Diabetes, Obesity & Metabolism
Jiang, Y;Chen, A;Kline, D;Liu, Q;Ma, J;Wang, Y;Zhang, T;Qian, J;Nelson, L;Prasadan, K;Hu, B;Gittes, GK;Xiao, X;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
To show that depletion of pancreatic macrophages impairs gestational beta cell proliferation and lea....
A transmissible ?? intraepithelial lymphocyte hyperproliferative phenotype is associated with the intestinal microbiota and confers protection against acute infection
Mucosal Immunology
Jia, L;Wu, G;Alonso, S;Zhao, C;Lemenze, A;Lam, YY;Zhao, L;Edelblum, KL;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Intraepithelial lymphocytes expressing the ?? T cell receptor (?? IELs) serve as a first line of def....
Zcchc12-containing nociceptors are required for noxious heat sensation
The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience
Wu, D;Chen, Y;Li, Z;Xie, H;Wang, S;Lu, Y;Bao, L;Zhang, X;Li, C;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Dorsal root ganglion (DRG) neurons are classified into distinct types to mediate the somatosensation....
Apolipoprotein E derived from CD11c+ cells ameliorates atherosclerosis
iScience
Sauter, M;Sauter, R;Nording, H;Lin, C;Olbrich, M;Autenrieth, S;Gleissner, C;Thunemann, M;Otero, N;Lutgens, E;Aherrahrou, Z;Wolf, D;Zender, L;Meuth, S;Feil, R;Langer, H;
Product: Diphtheria Toxin CRM197, Mutant
Atherosclerosis is studied in models with dysfunctional lipid homeostasis—predominantly the ApoE−/− ....
Pou4f3DTR Mice Enable Selective and Timed Ablation of Hair Cells in Postnatal Mice
Neuromethods
Stone, J;Rubel, E;Warchol, M;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Experimental studies of inner ear development and regeneration, as well as investigations of the inf....
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Increasing evidence shows that disseminated cancer cells (DCCs) can disseminate from early-evolved p....
Effective CD4 T cell priming requires repertoire scanning by CD301b+ migratory cDC2 cells upon lymph node entry
Science Immunology
Tatsumi, N;Codrington, AL;El-Fenej, J;Phondge, V;Kumamoto, Y;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
During the initiation of adaptive immune responses, millions of lymphocytes must be scanned to find ....
Remote Limb Ischemic Postconditioning Protects Against Ischemic Stroke by Promoting Regulatory T Cells Thriving
Journal Of The American Heart Association
Yu, HH;Ma, XT;Ma, X;Chen, M;Chu, YH;Wu, LJ;Wang, W;Qin, C;Tian, DS;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Background Remote limb ischemic postconditioning (RLIPoC) has been demonstrated to protect against i....
Elevated murine HB-EGF confers sensitivity to diphtheria toxin in EGFR-mutant lung adenocarcinoma
Disease Models & Mechanisms
Robles-Oteiza, C;Ayeni, D;Levy, S;Homer, RJ;Kaech, SM;Politi, K;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Conditional ablation of defined cell populations in vivo can be achieved using genetically engineere....
Regulatory T cells function in established systemic inflammation and reverse fatal autoimmunity
Nature Immunology
Hu, W;Wang, ZM;Feng, Y;Schizas, M;Hoyos, BE;van der Veeken, J;Verter, JG;Bou-Puerto, R;Rudensky, AY;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
The immunosuppressive function of regulatory T (Treg) cells is dependent on continuous expression of....
CD11b+ lung dendritic cells at different stages of maturation induce Th17 or Th2 differentiation
Nature Communications
Izumi, G;Nakano, H;Nakano, K;Whitehead, GS;Grimm, SA;Fessler, MB;Karmaus, PW;Cook, DN;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Dendritic cells (DC) in the lung that induce Th17 differentiation remain incompletely understood, in....
Selective ablation of inner hair cells and subsequent in-situ hair cell regeneration in the neonatal mouse cochlea
Hearing Research
Xia, M;Wu, M;Zhao, L;Ma, J;Li, W;Li, H;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Loss of hair cells (HCs) accounts for most sensorineural hearing loss, and regeneration of cochlear ....
The differentiation status of hair cells that regenerate naturally in the vestibular inner ear of the adult mouse
The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience
González-Garrido, A;Pujol, R;RamÃrez, OL;Finkbeiner, C;Eatock, RA;Stone, JS;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Aging, disease and trauma can lead to loss of vestibular hair cells and permanent vestibular dysfunc....
Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells
Nature
Casanova-Acebes, M;Dalla, E;Leader, AM;LeBerichel, J;Nikolic, J;Morales, BM;Brown, M;Chang, C;Troncoso, L;Chen, ST;Sastre-Perona, A;Park, MD;Tabachnikova, A;Dhainaut, M;Hamon, P;Maier, B;Sawai, CM;Agulló-Pascual, E;Schober, M;Brown, BD;Reizis, B;Marron, T;Kenigsberg, E;Moussion, C;Benaroch, P;Aguirre-Ghiso, JA;Merad, M;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Macrophages have a key role in shaping the tumour microenvironment (TME), tumour immunity and respon....
Deciphering an AgRP-serotoninergic neural circuit in distinct control of energy metabolism from feeding
Nature Communications
Han, Y;Xia, G;Srisai, D;Meng, F;He, Y;Ran, Y;He, Y;Farias, M;Hoang, G;Tóth, I;Dietrich, MO;Chen, MH;Xu, Y;Wu, Q;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Contrasting to the established role of the hypothalamic agouti-related protein (AgRP) neurons in fee....
Ghrelin Treatment Induces Rapid and Delayed Increments of Food Intake: A Heuristic Model to Explain Ghrelins Orexigenic Effects
Research Square
Cornejo, M;Denis, R;Romero, G;Fernandez, G;Reynaldo, M;Luquet, S;Perello, M;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Ghrelin is a stomach-derived peptide hormone with salient roles in the regulation of energy balance ....
Type 17 immunity promotes the exhaustion of CD8+ T cells in cancer
Journal For Immunotherapy Of Cancer
Kim, BS;Kuen, DS;Koh, CH;Kim, HD;Chang, SH;Kim, S;Jeon, YK;Park, YJ;Choi, G;Kim, J;Kang, KW;Kim, HY;Kang, SJ;Hwang, S;Shin, EC;Kang, CY;Dong, C;Chung, Y;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Background Multiple types of immune cells producing IL-17 are found in the tumor microenvironment. H....
Effect of Preexisting Immunity to Tetanus Toxoid on the Efficacy of Tetanus Toxoid-Conjugated Heroin Vaccine in Mice
Vaccines
Komla, E;Torres, OB;Jalah, R;Sulima, A;Beck, Z;Alving, CR;Jacobson, AE;Rice, KC;Matyas, GR;
Product: Diphtheria Toxoid, from Corynebacterium diphtheriae
Opioid use disorder (OUD) is a serious health problem that has dramatically increased over the last ....
IgE-activated mast cells enhance TLR4-mediated antigen-specific CD4+ T cell responses
Scientific Reports
Phong, BL;D'Souza, SJ;Baudier, RL;Wu, E;Immethun, VE;Bauer, DL;McLachlan, JB;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Mast cells are potent mediators of allergy and asthma, yet their role in regulating adaptive immunit....
Immunisation with the BCG and DTPw vaccines induces different programs of trained immunity in mice
Vaccine
Stevens, NE;van Wolfswinkel, M;Bao, W;Ryan, FJ;Brook, B;Amenyogbe, N;Marshall, HS;Lynn, MA;Kollmann, TR;Tumes, DJ;Lynn, DJ;
Product: Diphtheria Toxoid, from Corynebacterium diphtheriae
In addition to providing pathogen-specific immunity, vaccines can also confer nonspecific effects (N....
Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate
Nature Chemical Biology
Weiss, RJ;Spahn, PN;Chiang, AWT;Liu, Q;Li, J;Hamill, KM;Rother, S;Clausen, TM;Hoeksema, MA;Timm, BM;Godula, K;Glass, CK;Tor, Y;Gordts, PLSM;Lewis, NE;Esko, JD;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Heparan sulfate (HS) proteoglycans bind extracellular proteins that participate in cell signaling, a....
Nonpeptidergic neurons suppress mast cells via glutamate to maintain skin homeostasis
Cell
Zhang, S;Edwards, TN;Chaudhri, VK;Wu, J;Cohen, JA;Hirai, T;Rittenhouse, N;Schmitz, EG;Zhou, PY;McNeil, BD;Yang, Y;Koerber, HR;Sumpter, TL;Poholek, AC;Davis, BM;Albers, KM;Singh, H;Kaplan, DH;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Cutaneous mast cells mediate numerous skin inflammatory processes and have anatomical and functional....
Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets
Proceedings Of The National Academy Of Sciences Of The United States Of America
Wang, MY;Dean, ED;Quittner-Strom, E;Zhu, Y;Chowdhury, KH;Zhang, Z;Zhao, S;Li, N;Ye, R;Lee, Y;Zhang, Y;Chen, S;Yu, X;Leonard, DC;Poffenberger, G;Von Deylen, A;McCorkle, SK;Schlegel, A;Sloop, KW;Efanov, AM;Gimeno, RE;Scherer, PE;Powers, AC;Unger, RH;Holland, WL;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
We evaluated the potential for a monoclonal antibody antagonist of the glucagon receptor (Ab-4) to m....
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