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Description | Formulation | Abbrev. | Product # | ||||||
TOXIN | |||||||||
Diphtheria Toxin, unnicked from Corynebacterium diphtheriae | Lyophilized in Buffer | DT | 150 | ||||||
TOXOID | |||||||||
Diphtheria Toxoid, from Corynebacterium diphtheriae | Lyophilized in Buffer | DTd | 151 | ||||||
CRM | |||||||||
Diphtheria Toxin CRM Mutant | Lyophilized in Buffer | CRM 197 | 149A |
#149A (0.25 mg)
$525.00
#150 (1 mg)
Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
This product is Out of stock.Diphtheria toxin (DT) is synthesized by certain strains of Corynebacterium diphtheriae and secreted as an inactive proenzyme, composed of a single polypeptide chain having an approximate molecular weight of 58 kDa. DT enzymatic activity is expressed when the proenzyme is nicked into two fragments, A and B, linked by a disulfide bond, then reduced with thiols releasing the N-terminal A fragment (molecular weight 21 kDa). The C-terminal B fragment (molecular weight 37 kDa) has no apparent enzymatic activity but is required for toxicity. Evidence suggests that the B fragment is responsible for recognizing and binding the toxin to cell surface receptors.
Diphtheria toxin catalyzes the ADP-ribosylation of eukaryotic aminoacyl-transferase II (EF-2) using NAD as a substrate, the basis for its toxicity toward eukaryotic organisms. Diphtheria toxin receptor (DTR) is a cell-surface expressed heparin-binding epidermal growth factor-like growth factor precursor (HB-EGF). In monkey cells, another membrane protein, CD-9 increases the affinity of diphtheria toxin for HB-EGF, indicating that two proteins may function together as a receptor.
Sensitivity of mammalian cell lines to diphtheria toxin varies with the presence of receptors. Monkey Vero cells are highly sensitive, hamster cells moderately sensitive, whereas rat and mouse cells without receptors are resistant. An injection of DT has relatively minor effects on normal mice and is used to selectively and transiently deplete the population of specific types of immune cells genetically attached with simian or human DTR. Use of DT in this way allows the normal development of the immune system followed by the selective elimination of specific cells. These studies allow conclusions about the function of the modified cells in various processes.
Diphtheria toxin preparations from C. diphtheriae Park Williams strain 8, are highly purified and unnicked. When followed by trypsin treatment and reduction with dithiothreitol, DT from List exhibits high specific activity. Diphtheria toxin is active on CHO19 or Vero20 cells when diluted to a nanogram or less per milliliter.
Diphtheria toxin CRM Mutant (CRM 197) is a non-toxic, cross reactive DT mutant containing a lesion in the A chain blocking ADP-ribosylation. CRM results from a single base change in the structural gene resulting in the substitution of glutamic acid for glycine. While CRM shows no enzymatic activity, it is immunologically indistinguishable from diphtheria toxin.
In its applications, CRM 197 is similar to diphtheria toxoid. CRM has the advantage of being a well-defined protein in contrast to formaldehyde treated toxin (toxoid) which is non-specifically cross linked and subject to rearrangement. CRM functions as a carrier for polysaccharides and haptens, making them immunogenic.
Diphtheria toxin CRM Mutant preparations from C. diphtheriae are highly purified and migrate as a single major 58 kDa band when examined on SDS-PAGE.
Diphtheria toxoid (DTd) is prepared by formaldehyde inactivation of purified diphtheria toxin. Inactivated bacterial toxins, including DTd, are widely used as protein carriers chemically conjugated to oligosaccarides in licensed vaccines, which induce a more robust immune response against the carbohydrate.
Nature Immunology
Kalekar, LA;Schmiel, SE;Nandiwada, SL;Lam, WY;Barsness, LO;Zhang, N;Stritesky, GL;Malhotra, D;Pauken, KE;Linehan, JL;O'Sullivan, MG;Fife, BT;Hogquist, KA;Jenkins, MK;Mueller, DL;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Cell Reports
Ali, JM;Negus, MC;Conlon, TM;Harper, IG;Qureshi, MS;Motallebzadeh, R;Willis, R;Saeb-Parsy, K;Bolton, EM;Bradley, JA;Pettigrew, GJ;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Endocrinology
Willems, C;Fu, Q;Roose, H;Mertens, F;Cox, B;Chen, J;Vankelecom, H;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
European Journal Of Immunology
Moro-Sibilot, L;This, S;Blanc, P;Sanlaville, A;Sisirak, V;Bardel, E;Boschetti, G;Bendriss-Vermare, N;Defrance, T;Dubois, B;Kaiserlian, D;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
American Journal Of Respiratory Cell And Molecular Biology
Eldredge, LC;Treuting, PM;Manicone, AM;Ziegler, SF;Parks, WC;McGuire, JK;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
The EMBO Journal
Paterka, M;Siffrin, V;Voss, JO;Werr, J;Hoppmann, N;Gollan, R;Belikan, P;Bruttger, J;Birkenstock, J;Jung, S;Esplugues, E;Yogev, N;Flavell, RA;Bopp, T;Zipp, F;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Nature Immunology
Yang, J;Hu, S;Zhao, L;Kaplan, DH;Perdew, GH;Xiong, N;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Thesis
Manlove, LS;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Immunity
Legoux, FP;Lim, JB;Cauley, AW;Dikiy, S;Ertelt, J;Mariani, TJ;Sparwasser, T;Way, SS;Moon, JJ;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
F1000 Research
Zhou, YS;Ihmoda, IA;Phelps, RG;Bellamy, COS;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Thesis
Clouthier, DL;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
PNAS
Harper, SJ;Ali, JM;Wlodek, E;Negus, MC;Harper, IG;Chhabra, M;Qureshi, MS;Mallik, M;Bolton, E;Bradley, JA;Pettigrew, GJ;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Cell Metabolism
Denis, RG;Joly-Amado, A;Webber, E;Langlet, F;Schaeffer, M;Padilla, SL;Cansell, C;Dehouck, B;Castel, J;Delbs, AS;Martinez, S;Lacombe, A;Rouch, C;Kassis, N;Fehrentz, JA;Martinez, J;Verdi, P;Hnasko, TS;Palmiter, RD;Krashes, MJ;Gler, AD;Magnan, C;Luquet
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Immunity
Kashem, SW;Riedl, MS;Yao, C;Honda, CN;Vulchanova, L;Kaplan, DH;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Experimental Neurology
Morgan, RG;Gibbs, JT;Melief, EJ;Postupna, NO;Sherfield, EE;Wilson, A;Keene, CD;Montine, TJ;Palmiter, RD;Darvas, M;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Elife
Shah, S;Grotenbreg, GM;Rivera, A;Yap, GS;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Diabetes Metabolic Syndrome And Obesity: Targets And Therapy
Yang, C;Loehn, M;Jurczyk, A;Przewozniak, N;Leehy, L;Herrera, PL;Shultz, LD;Greiner, DL;Harlan, DM;Bortell, R;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Cell Reports
DeFalco, T;Potter, SJ;Williams, AV;Waller, B;Kan, MJ;Capel, B;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Hepatology
Lim, SY;Gordon-Weeks, A;Allen, D;Kersemans, V;Beech, J;Smart, S;Muschel, RJ;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
PLoS ONE
Awad, AS;You, H;Gao, T;Gvritishvili, A;Cooper, TK;Tombran-Tink, J;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Bioconjugate Chemistry
Jalah, R;Torres, OB;Mayorov, AV;Li, F;Antoline, JF;Jacobson, AE;Rice, KC;Deschamps, JR;Beck, Z;Alving, CR;Matyas, GR;
Product: Diphtheria Toxin CRM197, Mutant
Journal of Neurophysiology
Song, Y;Xia, A;Lee, HY;Wang, R;Ricci, AJ;Oghalai, JS;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Blood
Biswas, M;Sarkar, D;Kumar, SR;Nayak, S;Rogers, GL;Markusic, DM;Liao, G;Terhorst, C;Herzog, RW;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
American Journal Of Respiratory Cell And Molecular Biology
Singer, BD;Mock, JR;Aggarwal, NR;Garibaldi, BT;Sidhaye, VK;Florez, MA;Chau, E;Gibbs, KW;Mandke, P;Tripathi, A;Yegnasubramanian, S;King, LS;D'Alessio, FR;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Nature Communications
Wang, T;Chai, R;Kim, GS;Pham, N;Jansson, L;Nguyen, DH;Kuo, B;May, LA;Zuo, J;Cunningham, LL;Cheng, AG;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Current Microbiology
Ye, J;Luo, Y;Fang, W;Pan, J;Zhang, Z;Zhang, Y;Chen, Z;Jin, D;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Immunity
Kashem, SW;Igyrt, BZ;Gerami-Nejad, M;Kumamoto, Y;Mohammed, J;Jarrett, E;Drummond, RA;Zurawski, SM;Zurawski, G;Berman, J;Iwasaki, A;Brown, GD;Kaplan, DH;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Experimental Dermatology
Mathes, AL;Rice, L;Affandi, AJ;DiMarzio, M;Rifkin, IR;Stifano, G;Christmann, RB;Lafyatis, R;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
PLoS Pathogens
Caffrey, AK;Lehmann, MM;Zickovich, JM;Espinosa, V;Shepardson, KM;Watschke, CP;Hilmer, KM;Thammahong, A;Barker, BM;Rivera, A;Cramer, RA;Obar, JJ;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
PLoS Pathogens
Clouthier, DL;Zhou, AC;Wortzman, ME;Luft, O;Levy, GA;Watts, TH;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Thesis
Weatherstone, JH;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Molecular Pain
McCoy, ES;Zylka, MJ;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
EMBO Molecular Medicine
Glitzner, E;Korosec, A;Brunner, PM;Drobits, B;Amberg, N;Schonthaler, HB;Kopp, T;Wagner, EF;Stingl, G;Holcmann, M;Sibilia, M;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Frontiers In Immunology
Mueller, CG;Coles, MC;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
PLoS Pathogens
Nascimento, M;Huang, SC;Smith, A;Everts, B;Lam, W;Bassity, E;Gautier, EL;Randolph, GJ;Pearce, EJ;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Immunity
Burton, OT;Noval Rivas, M;Zhou, JS;Logsdon, SL;Darling, AR;Koleoglou, KJ;Roers, A;Houshyar, H;Crackower, MA;Chatila, TA;Oettgen, HC;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Mucosal Immunology
Mock, JR;Garibaldi, BT;Aggarwal, NR;Jenkins, J;Limjunyawong, N;Singer, BD;Chau, E;Rabold, R;Files, DC;Sidhaye, V;Mitzner, W;Wagner, EM;King, LS;D'Alessio, FR;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Thesis
Werr, J;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
PLoS ONE
Giovati, L;Gallo, A;Masoero, F;Cerioli, C;Ciociola, T;Conti, S;Magliani, W;Polonelli, L;
Product: Diphtheria Toxin CRM197, Mutant
Development
Cox, BC;Chai, R;Lenoir, A;Liu, Z;Zhang, L;Nguyen, DH;Chalasani, K;Steigelman, KA;Fang, J;Rubel, EW;Cheng, AG;Zuo, J;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
The American Journal Of Pathology
Wang, H;Melton, DW;Porter, L;Sarwar, ZU;McManus, LM;Shireman, PK;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Journal of Immunology
Jiao J, Dragomir AC, Kocabayoglu P, Rahman AH, Chow A, Hashimoto D, Leboeuf M, Kraus T, Moran T, Carrasco-Avino G, Friedman SL, Merad M, Aloman C
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Elife
Li, L;Ginty, DD;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Environmental Microbiology
Arnold, JW;Koudelka, GB;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
PLoS Pathogens
Espinosa, V;Jhingran, A;Dutta, O;Kasahara, S;Donnelly, R;Du, P;Rosenfeld, J;Leiner, I;Chen, CC;Ron, Y;Hohl, TM;Rivera, A;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Nature Immunology
Li, S;Rouphael, N;Duraisingham, S;Romero-Steiner, S;Presnell, S;Davis, C;Schmidt, DS;Johnson, SE;Milton, A;Rajam, G;Kasturi, S;Carlone, GM;Quinn, C;Chaussabel, D;Palucka, AK;Mulligan, MJ;Ahmed, R;Stephens, DS;Nakaya, HI;Pulendran, B;
Product: Diphtheria Toxoid, from Corynebacterium diphtheriae
Thesis
Osokine, I;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
American Journal Of Physiology - Renal Physiology
You, H;Gao, T;Cooper, TK;Brian Reeves, W;Awad, AS;
Product: Diphtheria Toxin CRM197, Mutant
PNAS
Feig, C;Jones, JO;Kraman, M;Wells, RJ;Deonarine, A;Chan, DS;Connell, CM;Roberts, EW;Zhao, Q;Caballero, OL;Teichmann, SA;Janowitz, T;Jodrell, DI;Tuveson, DA;Fearon, DT;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Journal Of Clinical & Cellular Immunology
Watanabe, K;Muro, Y;Sugiura, K;Akiyama, M;
Product: Diphtheria Toxoid, from Corynebacterium diphtheriae
Nature
Carter, ME;Soden, ME;Zweifel, LS;Palmiter, RD;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Immunity
Kumamoto, Y;Linehan, M;Weinstein, JS;Laidlaw, BJ;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
PNAS
Wu, Q;Zheng, R;Srisai, D;McKnight, GS;Palmiter, RD;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Blood
Terrell, CE;Jordan, MB;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
The American Journal Of Pathology
He, L;Marneros, AG;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Shock
Bosmann, M;Grailer, JJ;Russkamp, NF;Ruemmler, R;Zetoune, FS;Sarma, JV;Ward, PA;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Neuron
McCoy, ES;Taylor-Blake, B;Street, SE;Pribisko, AL;Zheng, J;Zylka, MJ;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
The Journal of Neuroscience
Mahrt, EJ;Perkel, DJ;Tong, L;Rubel, EW;Portfors, CV;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
The Journal of Immunology
Lang, J;Kelly, M;Freed, BM;McCarter, MD;Kedl, RM;Torres, RM;Pelanda, R;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
The Journal of Neuroscience
Knowlton, WM;Palkar, R;Lippoldt, EK;McCoy, DD;Baluch, F;Chen, J;McKemy, DD;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
PLoS ONE
Ryder, M;Gild, M;Hohl, TM;Pamer, E;Knauf, J;Ghossein, R;Joyce, JA;Fagin, JA;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Growth Factors
Su, Y;Yang, J;Besner, GE;
Product: Diphtheria Toxin CRM197, Mutant
The Journal of Neuroscience
Whiddon, BB;Palmiter, RD;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Immunity
Chang, SY;Song, J;Guleng, B;Cotoner, CA;Arihiro, S;Zhao, Y;Chiang, H;O'Keeffe, M;Liao, G;LKarp, C;Kweon, M;Sharpe, AH;Bhan, A;Terhorst, C;Reinecker, H;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Immunity
Chang, SY;Song, JH;Guleng, B;Cotoner, CA;Arihiro, S;Zhao, Y;Chiang, HS;O'Keeffe, M;Liao, G;Karp, CL;Kweon, MN;Sharpe, AH;Bhan, A;Terhorst, C;Reinecker, HC;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Thesis
Vo, JOH;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Hepatology
Zhao, L;Lim, SY;Gordon-Weeks, AN;Tapmeier, TT;Im, JH;Cao, Y;Beech, J;Allen, D;Smart, S;Muschel, RJ;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Thesis
Schafferus, M;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Frontiers In Cellular And Infection Microbiology
Burtnick, MN;Heiss, C;Schuler, AM;Azadi, P;Brett, PJ;
Product: Diphtheria Toxin CRM197, Mutant
Proceedings Of The National Academy Of Sciences Of The United States Of America
Ramachandran, P;Pellicoro, A;Vernon, MA;Boulter, L;Aucott, RL;Ali, A;Hartland, SN;Snowdon, VK;Cappon, A;Gordon-Walker, TT;Williams, MJ;Dunbar, DR;Manning, JR;van Rooijen, N;Fallowfield, JA;Forbes, SJ;Iredale, JP;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience
Golub, JS;Tong, L;Ngyuen, TB;Hume, CR;Palmiter, RD;Rubel, EW;Stone, JS;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
European Journal Of Immunology
Leonardo, SM;De Santis, JL;Gehrand, A;Malherbe, LP;Gauld, SB;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Frontiers In Immunology
Kumar, V;Chyou, S;Stein, JV;Lu, TT;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Vaccine
Tonkin, DR;Whitmore, A;Johnston, RE;Barro, M;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Cell Host & Microbe
Wilson, EB;Kidani, Y;Elsaesser, H;Barnard, J;Raff, L;Karp, CL;Bensinger, S;Brooks, DG;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
The Journal Of Clinical Investigation
Gomez de Agero, M;Vocanson, M;Hacini-Rachinel, F;Taillardet, M;Sparwasser, T;Kissenpfennig, A;Malissen, B;Kaiserlian, D;Dubois, B;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Rheumatology
Muro, Y;Sugiura, K;Hoshino, K;Akiyama, M;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Journal Of Immunology
Cervantes-Barragn, L;Firner, S;Bechmann, I;Waisman, A;Lahl, K;Sparwasser, T;Thiel, V;Ludewig, B;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Blood
Gil-Bernab, AM;Ferjancic, S;Tlalka, M;Zhao, L;Allen, PD;Im, JH;Watson, K;Hill, SA;Amirkhosravi, A;Francis, JL;Pollard, JW;Ruf, W;Muschel, RJ;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Proceedings Of The National Academy Of Sciences Of The United States Of America
Rode, I;Boehm, T;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Immunity
Kinnebrew MA, Buffie CG, Diehl GE, Zenewicz LA, Leiner I, Hohl TM, Flavell RA, Littman DR, Pamer EG
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Immunity
Kinnebrew, MA;Buffie, CG;Diehl, GE;Zenewicz, LA;Leiner, I;Hohl, TM;Flavell, RA;Littman, DR;Pamer, EG;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Proceedings Of The National Academy Of Sciences Of The United States Of America
Wu, Q;Whiddon, BB;Palmiter, RD;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Hepatology
Jiao, J;Sastre, D;Fiel, MI;Lee, UE;Ghiassi-Nejad, Z;Ginhoux, F;Vivier, E;Friedman, SL;Merad, M;Aloman, C;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
Journal Of Immunology
Martinez, RJ;Zhang, N;Thomas, SR;Nandiwada, SL;Jenkins, MK;Binstadt, BA;Mueller, DL;
Product: Diphtheria Toxin, Unnicked, from Corynebacterium diphtheriae
October 17, 2019
By: List Labs
List Labs currently has over 3300 citations with more being added every month! Within our citations page, we provide the ability to search and sort from over 100 cataloged items that are offered here. We are honored to supply researchers worldwide with highly purified bacterial toxins that can potentially be instrumental in helping to change […]
July 23, 2018
By: douano@listlabs.com
By: Mary N. Wessling, Ph.D. ELS In this blog we will unravel the terminology describing bacterial toxins. In general, there are at least three ways that bacterial toxins are described in the literature: by their biological designation—the genus and/or species from which they come by the origin of the toxin, either as innate to the […]
March 19, 2018
By: douano@listlabs.com
By: Mary N. Wessling, Ph.D. ELS List Biological Laboratories’ (List Labs) catalog of products is related to furthering research in human health and preventing disease, most commonly as the starting materials for vaccine research & development or production around the world. Vaccines are mainly identified for their capacity to prevent diseases that the body’s innate defensive […]
January 8, 2018
By: douano@listlabs.com
By: Rachel Berlin, Marketing Manager The List Labs website hosts a library of scientific article abstracts related to the research performed using our products called the Citations Page. Visitors can search this library to learn how others have used List Labs’ reagents in their research. This valuable resource is updated monthly with new articles from a wide variety […]
March 27, 2017
By: douano@listlabs.com
By: Mary N. Wessling, Ph.D. ELS Cross-Reacting Materials: The Motor Behind Conjugate Vaccines Vaccines in history The history and practice of vaccination as protection against viral infection is often thought to begin with Edward Jenner’s discovery that cowpox, a viral infection of cows, prevented smallpox in humans. However, it had long been suspected that survivors […]
December 12, 2016
By: List Labs
By: Suzanne Canada, Ph.D. Diphtheria toxin is an important tool used for selective killing (ablation) of cells for research purposes. Using this technique, dubbed “toxin receptor–mediated cell knockout” when it was first used [1], researchers can selectively remove a specific type of cell in a live mouse without having to generate transgenic “knockout” animals, which […]
August 15, 2016
By: douano@listlabs.com
By: Md. Elias, Ph.D, Senior Scientist List Labs is one of the leading manufacturers of high quality adjuvants from bacterial sources. Our highly purified adjuvants for research and development are Tetanus Toxoid (Product #191), Cholera Toxin B Subunit (Product #104), Diphtheria Toxin CRM197 Mutant (Product #149), Adenylate Cyclase Mutant, Cya-AC– (Product #198L), Pertusis Toxin Mutant (Product #184), […]
April 25, 2016
By: douano@listlabs.com
By: Karen Crawford, Ph.D., President In 1983, List Labs introduced Diphtheria Toxin to the research community. Researchers have purchased Diphtheria Toxin for various uses. One common use is cell ablation. The receptor for Diphtheria Toxin is also called heparin-binding EGF-like growth factor (HB-EGF). This receptor, located on several cell types, binds Diphtheria Toxin, allowing the toxin to enter […]
April 6, 2015
By: List Labs
By: Suzanne Canada, Ph.D. Tanager Medical Writing Concerns over outbreaks of potentially serious childhood diseases are in the news again in California with an increase in whooping cough infections in 2014, caused by the pathogen Bordetella pertussis, and a measles outbreak in December 2014 to February 2015. Since outbreaks and epidemics may be infrequent, many […]
January 26, 2015
By: List Labs
By: Suzanne Canada, Ph.D. Tanager Medical Writing An exciting report was released in October about a new class of targeted anti-tumor drugs, in which genetically engineered stem cells were used to deliver cytotoxins to brain tumors.1 Brain cancers known as glioblastomas (GBM) are notoriously difficult to treat because the tumors often re-grow after surgery and because […]
October 21, 2014
By: List Labs
By: Suzanne Canada, Ph.D. Tanager Medical Writing Vaccines have been used to help control diseases for more than 200 years and are the common practice for children and adults. Childhood vaccination has substantially reduced the morbidity and mortality from infectious diseases in much of the developed world, and influenza vaccinations have reduced the impact […]
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