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Source Strain | LPS Purity | Product # | ||||
E. coli O113 | ListTM HPTTM LPS | 433 | ||||
E. coli O111:B4 | Standard Purity | 201 | ||||
Ultra Pure | 421 | |||||
E. coli O55:B5 | Standard Purity | 203 | ||||
Ultra Pure | 423 | |||||
E. coli J5 (Rc) | Standard Purity | 301 | ||||
E. coli K12, D31m4 (Re) | Standard Purity | 302 | ||||
E. coli K12 strain LCD25 | Standard Purity | 314 |
Source Species | LPS Purity | Product # | ||||
S. minnesota R595 (Re) | Standard Purity | 304 | ||||
Ultra Pure | 434 | |||||
Lipid A from S. minnesota R595 | Standard Purity | 401 | ||||
S. typhimurium | Standard Purity | 225 |
#201 (5 mg)
$325.00
#203A (2.5 mg)
$345.00
#225 (5 mg)
$220.00
#302 (5 mg)
$200.00
#304 (5 mg)
$200.00
#314 (1 mg)
$200.00
$240.00
List Labs provides endotoxin or lipopolysaccharides (LPS) for research and clinical investigation. This material has been extracted from bacterial cell walls of different strains of E. coli, Salmonella typhimurium and Salmonella minnesota. Several of the endotoxins have been further purified to remove traces of residual protein and nucleic acids, producing either the Ultra Pure or HPTTM. Contact us for more information about E. coli O113, extracted at high purity and under GMP conditions for use in clinical trials: GMP ListTM HPTTM LPS.
LPS structure may be generally described as three linked regions. The first structural feature is the lipid component called Lipid A, primarily responsible for the effects of endotoxin. Linked to Lipid A is the core antigen or R polysaccharide, a short chain of sugars including 2-keto 3-deoxyoctonate (KDO). The third structural feature is attached to the core polysaccharide and is more elaborate, containing up to 40 repeating subunits of 3 to 5 sugars, referred to as the O antigen, O side chain or O polysaccharide. Variations in the composition of the O antigen account for different antibody responses to bacteria species. Lipid A, acting alone or as a component of LPS, is a potent modulator of the mammalian immune response. The presence of Lipid A or LPS in mammalian macrophages or endothelial cells triggers a signaling cascade leading to the secretion of pro-inflammatory cytokines and nitric oxide. LPS also acts as a B cell mitogen.
To follow is a list of LPS available for purchase, sorted by the bacteria stains from which it was derived. Find also on this list, monophosphoryl Lipid A (MPLA) prepared from Salmonella minnesota R595 (Re). All LPS sold by List Labs has been made in the USA.
PLoS ONE
Lew, WY;Bayna, E;Molle, ED;Dalton, ND;Lai, NC;Bhargava, V;Mendiola, V;Clopton, P;Tang, T;
Product: LPS from Escherichia coli O55:B5
Advances In Bioscience And Biotechnology
Koulchitsky, SV;Pashkevich, SG;Navasiolava, NM;Custaud, M;Kulchitsky, VA;
Product: LPS from Escherichia coli O111:B4
The Journal Of Biological Chemistry
Rubinow, KB;Wall, VZ;Nelson, J;Mar, D;Bomsztyk, K;Askari, B;Lai, MA;Smith, KD;Han, MS;Vivekanandan-Giri, A;Pennathur, S;Albert, CJ;Ford, DA;Davis, RJ;Bornfeldt, KE;
Product: ULTRA PURE LPS from Escherichia coli O111:B4
The Journal of Immunology
Guo, L;Stripay, JL;Zhang, X;Collage, RD;Hulver, M;Carchman, EH;Howell, GM;Zuckerbraun, BS;Lee, JS;Rosengart, MR;
Product: ULTRA PURE LPS from Escherichia coli O111:B4
Translational Stroke Research
Stridh, L;Ek, CJ;Wang, X;Nilsson, H;Mallard, C;
Product: ULTRA PURE LPS from Escherichia coli O55:B5
American Journal of Physiology - Lung Cellular and Molecular Physiology
Zemans, RL;McClendon, J;Aschner, Y;Briones, N;Young, SK;Lau, LF;Kahn, M;Downey, GP;
Product: LPS from Escherichia coli O111:B4
Arteriosclerosis, Thrombosis and Vascular Biology
de Jager, SC;Bot, I;Kraaijeveld, AO;Korporaal, SJ;Bot, M;van Santbrink, PJ;van Berkel, TJ;Kuiper, J;Biessen, EA;
Product: LPS from Salmonella minnesota R595 (Re)
European Journal Of Immunology
Yee, NK;Hamerman, JA;
Product: ULTRA PURE LPS from Salmonella minnesota R595 (Re)
Vaccine
Myc, A;Kukowska-Latallo, JF;Smith, DM;Passmore, C;Pham, T;Wong, P;Bielinska, AU;Baker, JR;
Product: LPS from Salmonella minnesota R595 (Re)
The Journal Of Biological Chemistry
De Arras, L;Seng, A;Lackford, B;Keikhaee, MR;Bowerman, B;Freedman, JH;Schwartz, DA;Alper, S;
Product: LPS from Escherichia coli O111:B4
American Journal Of Physiology - Gastrointestinal And Liver Physiology
Ganguli, K;Meng, D;Rautava, S;Lu, L;Walker, WA;Nanthakumar, N;
Product: ULTRA PURE LPS from Escherichia coli O55:B5
Product: LPS from Escherichia coli O111:B4
The Journal of Immunology
Ehrentraut, SF;Kominsky, DJ;Glover, LE;Campbell, EL;Kelly, CJ;Bowers, BE;Bayless, AJ;Colgan, SP;
Product: LPS from Escherichia coli O55:B5
Cell Host & Microbe
LaRock, CN;Cookson, BT;
Product: ULTRA PURE LPS from Salmonella minnesota R595 (Re)
Innate Immunity
Aikawa, N;Okubo, Y;Lynn, M;Rossignol, DP;Wong, YN;Schuck, E;Kitahara, Y;Nakano, T;Sivak, O;Wasan, KM;Nagy, C;Yen, M;
Product: LPS from Escherichia coli O111:B4
Product: LPS from Salmonella typhimurium
EMBO Molecular Medicine
Chassin, C;Hempel, C;Stockinger, S;Dupont, A;Kbler, JF;Wedemeyer, J;Vandewalle, A;Hornef, MW;
Product: LPS from Escherichia coli K12, D31m4 (Re)
Thesis
Kandhi, V;
Product: LPS from Salmonella minnesota R595 (Re)
Plos One
Dittrich, AS;Winkler, T;Wellman, T;de Prost, N;Musch, G;Harris, RS;Vidal Melo, MF;
Product: LPS from Escherichia coli O55:B5
Journal Of Immunology
Davis, MJ;Gregorka, B;Gestwicki, JE;Swanson, JA;
Product: LPS from Salmonella typhimurium
Clinical And Vaccine Immunology
Som, A;Navasa, N;Percher, A;Scott, RW;Tew, GN;Anguita, J;
Product: ULTRA PURE LPS from Salmonella minnesota R595 (Re)
Annals Of Neurology
Nobuta, H;Ghiani, CA;Paez, PM;Spreuer, V;Dong, H;Korsak, RA;Manukyan, A;Li, J;Vinters, HV;Huang, EJ;Rowitch, DH;Sofroniew, MV;Campagnoni, AT;de Vellis, J;Waschek, JA;
Product: LPS from Escherichia coli O55:B5
Nature
Qu, Y;Misaghi, S;Izrael-Tomasevic, A;Newton, K;Gilmour, LL;Lamkanfi, M;Louie, S;Kayagaki, N;Liu, J;Kmves, L;Cupp, JE;Arnott, D;Monack, D;Dixit, VM;
Product: LPS from Escherichia coli O111:B4
The Journal Of Neuroscience : The Official Journal Of The Society For Neuroscience
Cameron, B;Tse, W;Lamb, R;Li, X;Lamb, BT;Landreth, GE;
Product: LPS from Escherichia coli O111:B4
The Journal Of Biological Chemistry
Shao, H;Lee, S;Gae-Scott, S;Nakata, C;Chen, S;Hamad, AR;Chakravarti, S;
Product: ULTRA PURE LPS from Escherichia coli O111:B4
The Journal Of Biological Chemistry
Chanthaphavong, RS;Loughran, PA;Lee, TY;Scott, MJ;Billiar, TR;
Product: ULTRA PURE LPS from Escherichia coli O111:B4
Blood
Brennan, TV;Lin, L;Huang, X;Cardona, DM;Li, Z;Dredge, K;Chao, NJ;Yang, Y;
Product: LPS from Escherichia coli O111:B4
Immunology And Cell Biology
Piao, JH;Yagita, H;Okumura, K;Nakano, H;
Product: LPS from Salmonella minnesota R595 (Re)
Inflammation
Li, P;Neubig, RR;Zingarelli, B;Borg, K;Halushka, PV;Cook, JA;Fan, H;
Product: ULTRA PURE LPS from Escherichia coli O111:B4
Cell Host & Microbe
McDonald, B;Urrutia, R;Yipp, BG;Jenne, CN;Kubes, P;
Product: LPS from Escherichia coli O111:B4
Journal Of Lipid Research
Huang, S;Rutkowsky, JM;Snodgrass, RG;Ono-Moore, KD;Schneider, DA;Newman, JW;Adams, SH;Hwang, DH;
Product: ULTRA PURE LPS from Escherichia coli O111:B4
Product: LPS from Salmonella minnesota R595 (Re)
Plos One
Kim, YI;Park, JE;Kwon, KH;Hong, CY;Yi, AK;
Product: ULTRA PURE LPS from Escherichia coli O111:B4
Journal Of Immunology
Shah, JA;Vary, JC;Chau, TT;Bang, ND;Yen, NT;Farrar, JJ;Dunstan, SJ;Hawn, TR;
Product: ULTRA PURE LPS from Salmonella minnesota R595 (Re)
Journal Of Immunology
Lin, T;Sammy, F;Yang, H;Thundivalappil, S;Hellman, J;Tracey, KJ;Warren, HS;
Product: LPS from Escherichia coli O55:B5
American Journal Of Respiratory Cell And Molecular Biology
Tanino, Y;Chang, MY;Wang, X;Gill, SE;Skerrett, S;McGuire, JK;Sato, S;Nikaido, T;Kojima, T;Munakata, M;Mongovin, S;Parks, WC;Martin, TR;Wight, TN;Frevert, CW;
Product: LPS from Escherichia coli O111:B4
Immunobiology
Jusek, G;Reim, D;Tsujikawa, K;Holzmann, B;
Product: ULTRA PURE LPS from Salmonella minnesota R595 (Re)
The Journal Of Biological Chemistry
Karauzum, H;Chen, G;Abaandou, L;Mahmoudieh, M;Boroun, AR;Shulenin, S;Devi, VS;Stavale, E;Warfield, KL;Zeitlin, L;Roy, CJ;Sidhu, SS;Aman, MJ;
Product: LPS from Escherichia coli O55:B5
Thesis
Kaczorowski, DJ;Scott, MJ;Pibris, JP;Afrazi, A;Nakao, A;Edmonds, RD;Kim, S;Kwak, JH;Liu, Y;Fan, J;Billiar, TR;
Product: ULTRA PURE LPS from Escherichia coli O111:B4
Neurogastroenterology And Motility
Buchholz, BM;Chanthaphavong, RS;Billiar, TR;Bauer, AJ;
Product: ULTRA PURE LPS from Escherichia coli O111:B4
The Journal Of Allergy And Clinical Immunology
Philbin, VJ;Dowling, DJ;Gallington, LC;Corts, G;Tan, Z;Suter, EE;Chi, KW;Shuckett, A;Stoler-Barak, L;Tomai, M;Miller, RL;Mansfield, K;Levy, O;
Product: ULTRA PURE LPS from Salmonella minnesota R595 (Re)
Thesis
Shatynski, KE;
Product: LPS from Escherichia coli O111:B4
Journal Of Proteome Research
Hoerr, V;Zbytnuik, L;Leger, C;Tam, PP;Kubes, P;Vogel, HJ;
Product: LPS from Escherichia coli O111:B4
The Journal Of Nutritional Biochemistry
Dawson, K;Zhao, L;Adkins, Y;Vemuri, M;Rodriguez, RL;Gregg, JP;Kelley, DS;Hwang, DH;
Product: LPS from Escherichia coli O111:B4
Arthritis And Rheumatism
Niederer, F;Trenkmann, M;Ospelt, C;Karouzakis, E;Neidhart, M;Stanczyk, J;Kolling, C;Gay, RE;Detmar, M;Gay, S;Jngel, A;Kyburz, D;
Product: LPS from Escherichia coli J5 (Rc)
The Journal Of Biological Chemistry
Fournier, B;Andargachew, R;Robin, AZ;Laur, O;Voelker, DR;Lee, WY;Weber, D;Parkos, CA;
Product: LPS from Salmonella minnesota R595 (Re)
Nature Medicine
Amanna, IJ;Rau, HP;Slifka, MK;
Product: LIPID A monophosphoryl from Salmonella minnesota R595
Molecular Endocrinology
Suarez, PE;Rodriguez, EG;Soundararajan, R;Mrillat, AM;Stehle, JC;Rotman, S;Roger, T;Voirol, MJ;Wang, J;Gross, O;Ptrilli, V;Nadra, K;Wilson, A;Beermann, F;Pralong, FP;Maillard, M;Pearce, D;Chrast, R;Rossier, BC;Hummler, E;
Product: ULTRA PURE LPS from Salmonella minnesota R595 (Re)
Immunity
Cole, C;Thomas, S;Filak, H;Henson, PM;Lenz, LL;
Product: LPS from Escherichia coli O111:B4
Plos One
Tagawa, K;Yoshihara, T;Shibata, T;Kitazaki, K;Endo, Y;Fujita, T;Koshiba, T;Kawabata, S;
Product: LPS from Salmonella minnesota R595 (Re)
British Journal Of Pharmacology
Aoki, Y;Hatakeyama, N;Yamamoto, S;Kinoshita, H;Matsuda, N;Hattori, Y;Yamazaki, M;
Product: LPS from Escherichia coli O55:B5
Cellular Immunology
Yanagita, M;Kobayashi, R;Kojima, Y;Mori, K;Murakami, S;
Product: LPS from Salmonella minnesota R595 (Re)
The Journal Of Experimental Medicine
Gold, ES;Ramsey, SA;Sartain, MJ;Selinummi, J;Podolsky, I;Rodriguez, DJ;Moritz, RL;Aderem, A;
Product: LPS from Salmonella minnesota R595 (Re)
Genes And Immunity
Thuong, NT;Hawn, TR;Chau, TT;Bang, ND;Yen, NT;Thwaites, GE;Teo, YY;Seielstad, M;Hibberd, M;Lan, NT;Caws, M;Farrar, JJ;Dunstan, SJ;
Product: LPS from Salmonella minnesota R595 (Re)
Journal Of Immunology
De Arras, L;Yang, IV;Lackford, B;Riches, DW;Prekeris, R;Freedman, JH;Schwartz, DA;Alper, S;
Product: LPS from Escherichia coli O111:B4
The Journal Of Infectious Diseases
Rubino, I;Coste, A;Le Roy, D;Roger, T;Jaton, K;Boeckh, M;Monod, M;Latg, JP;Calandra, T;Bochud, PY;
Product: ULTRA PURE LPS from Salmonella minnesota R595 (Re)
Journal Of Proteome Research
Sylvester, JE;Bray, TS;Kron, SJ;
Product: LPS from Escherichia coli O111:B4
Plos One
von Maltzan, K;Tan, W;Pruett, SB;
Product: ULTRA PURE LPS from Escherichia coli O111:B4
Innate Immunity
Rutledge, HR;Jiang, W;Yang, J;Warg, LA;Schwartz, DA;Pisetsky, DS;Yang, IV;
Product: ULTRA PURE LPS from Escherichia coli O111:B4
Immunology Letters
Chen, WH;Toapanta, FR;Shirey, KA;Zhang, L;Giannelou, A;Page, C;Frieman, MB;Vogel, SN;Cross, AS;
Product: LPS from Escherichia coli O111:B4
Journal Of Immunology
Konter, JM;Parker, JL;Baez, E;Li, SZ;Ranscht, B;Denzel, M;Little, FF;Nakamura, K;Ouchi, N;Fine, A;Walsh, K;Summer, RS;
Product: LPS from Escherichia coli O55:B5
Cellular & Molecular Immunology
Seit-Nebi, A;Cheng, W;Xu, H;Han, J;
Product: LPS from Escherichia coli O111:B4
Immunology
Ochiel, DO;Rossoll, RM;Schaefer, TM;Wira, CR;
Product: LPS from Salmonella minnesota R595 (Re)
Journal Of Cellular Biochemistry
Kleveta, G;Borzcka, K;Zdioruk, M;Czerkies, M;Kuberczyk, H;Sybirna, N;Sobota, A;Kwiatkowska, K;
Product: ULTRA PURE LPS from Escherichia coli O111:B4
Digestive And Liver Disease : Official Journal Of The Italian Society Of Gastroenterology And The Italian Association For The Study Of The Liver
Okogbule-Wonodi, AC;Li, G;Anand, B;Luzina, IG;Atamas, SP;Blanchard, T;
Product: ULTRA PURE LPS from Escherichia coli O111:B4
Thesis
Nguyen, TT;
Product: ULTRA PURE LPS from Salmonella minnesota R595 (Re)
Proceedings Of The National Academy Of Sciences Of The United States Of America
Ni, M;IV, AW;Toft, M;Lowell, CA;Campbell, KS;Hamerman, JA;
Product: LPS from Salmonella minnesota R595 (Re)
Journal of Inflammation
Blomkalns AL, Stoll LL, Shaheen W, Romig-Martin SA, Dickson EW, Weintraub NL, Denning GM
Product: LPS from Escherichia coli K12 strain LCD25
Clinical Chemistry
Newhall KJ, Diemer GS, Leshinsky N, Kerkof K, Chute HT, Russell CB, Rees W, Welcher AA, Patterson SD, Means GD
Product: LPS from Escherichia coli O111:B4
Journal of Immunolgy
Zhao XJ, Dong Q, Bindas J, Piganelli JD, Magill A, Reiser J, Kolls JK
Product: LPS from Escherichia coli O111:B4
Journal of Immunology
Tydell CC, Yuan J, Tran P, Selsted ME
Product: LPS from Salmonella typhimurium
Journal of Experimental Medicine
Hornef M, Henriques Normark B, Vandewalle A, Normark S
Product: LIPID A monophosphoryl from Salmonella minnesota R595
Journal of Cell Science
Triantafilou M, Miyake K, Golenbock DT, Triantafilou K
Product: LPS from Salmonella minnesota R595 (Re)
American Journal of Respiratory Cell and Molecular Biology
Stamme C, Walsh E, Wright JR
Product: LPS from Escherichia coli K12 strain LCD25
August 30, 2021
By: douano@listlabs.com
List Labs currently has a GMP compliant version of HPT™ Lipopolysaccharide from Escherichia coli O113 in stock. What this means for you: You don’t need to buy an entire batch of lipopolysaccharide or wait months for production and release – Saves you valuable time Paying for as few as 50 vials of a proven product and purchasing […]
July 23, 2018
By: douano@listlabs.com
By: Mary N. Wessling, Ph.D. ELS In this blog we will unravel the terminology describing bacterial toxins. In general, there are at least three ways that bacterial toxins are described in the literature: by their biological designation—the genus and/or species from which they come by the origin of the toxin, either as innate to the […]
January 8, 2018
By: douano@listlabs.com
By: Rachel Berlin, Marketing Manager The List Labs website hosts a library of scientific article abstracts related to the research performed using our products called the Citations Page. Visitors can search this library to learn how others have used List Labs’ reagents in their research. This valuable resource is updated monthly with new articles from a wide variety […]
August 29, 2017
By: dpinkston@listlabs.com
The origin of businesses is often an interesting story. List Biological Laboratories is no exception. The company was founded in 1978 by Linda Shoer. Linda was an entrepreneurial scientist in Silicon Valley, who’d been relocated with her husband from Boston. She had an idea for a company and leveraged an initial order into a loan […]
March 6, 2017
By: douano@listlabs.com
By: Md. Elias, Ph.D, Senior Scientist What are Endotoxins? Endotoxins (aka lipopolysaccharide, LPS or lipoglycan) are part of the outer membrane of Gram-negative bacteria consisting of a lipid moiety and a polysaccharide moiety, the latter is composed of an inner core, outer core and O-antigen joined by covalent bonds1. In animals the lipid part of […]
August 15, 2016
By: douano@listlabs.com
By: Md. Elias, Ph.D, Senior Scientist List Labs is one of the leading manufacturers of high quality adjuvants from bacterial sources. Our highly purified adjuvants for research and development are Tetanus Toxoid (Product #191), Cholera Toxin B Subunit (Product #104), Diphtheria Toxin CRM197 Mutant (Product #149), Adenylate Cyclase Mutant, Cya-AC– (Product #198L), Pertusis Toxin Mutant (Product #184), […]
June 22, 2015
By: douano@listlabs.com
By: Karen Crawford, Ph.D., President Eva Purro, Director of Quality Assurance Dom C. Ouano, Marketing While most of List Labs’ products are intended as research reagents (Research Grade), several can be produced as GMP products for use in humans. Below are key differences between the two. Research Only VS Preclinical/Clinical/Human Use Reagent grade products for […]
April 6, 2015
By: List Labs
By: Suzanne Canada, Ph.D. Tanager Medical Writing Concerns over outbreaks of potentially serious childhood diseases are in the news again in California with an increase in whooping cough infections in 2014, caused by the pathogen Bordetella pertussis, and a measles outbreak in December 2014 to February 2015. Since outbreaks and epidemics may be infrequent, many […]
December 15, 2014
By: douano@listlabs.com
By: Karen Crawford, Ph.D. President, List Biological Laboratories, Inc. Many bacterial products are potent immune system activators, helping our bodies identify and defend against microbial invasions. The innate immune system or non-specific immune system is found in animals as well as in plants, fungi and insects and is employed when pathogens break through the […]
October 21, 2014
By: List Labs
By: Suzanne Canada, Ph.D. Tanager Medical Writing Vaccines have been used to help control diseases for more than 200 years and are the common practice for children and adults. Childhood vaccination has substantially reduced the morbidity and mortality from infectious diseases in much of the developed world, and influenza vaccinations have reduced the impact […]
June 17, 2014
By: dpinkston@listlabs.com
What is Lipopolysaccharide (LPS) and How Does it Function? Lipopolysaccharide (LPS), a component of the outer membrane of Gram-negative bacteria, is a potent stimulator of the vertebrate innate immune system. This innate immune system, mediated by macrophages and dendritic cells, generates a rapid response to infectious agents. Structural patterns common to diverse LPS molecules are […]
Have a specific question about your LBP project? Click below and let’s get started.
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